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    Solid phase peptide synthesis using a polyacrylic support in aqueous solution
    1.
    发明授权
    Solid phase peptide synthesis using a polyacrylic support in aqueous solution 失效
    在水溶液中使用聚丙烯酸载体的固相肽合成

    公开(公告)号：US5175254A

    公开(公告)日：1992-12-29

    申请号：US766899

    申请日：1991-09-26

    申请人： Bernard Calas ,  Jean Mery ,  Hanitra Naharisoa ,  Michel Follet

    发明人： Bernard Calas ,  Jean Mery ,  Hanitra Naharisoa ,  Michel Follet

    IPC分类号： C07K1/04

    CPC分类号： C07K1/04

    摘要： This invention relates to solid phase peptide synthesis.Solid phase peptide synthesis is accomplished on polyacrylic resins (such as those described in EP 0 079 812 and EP 0 081 408 which correspond to U.S. Pat. Nos. 4,436,874 and 4,439,545 respectively) by a method which includes in the coupling protocol steps of washing the resin in water and/or aqueous solution(s).

    摘要翻译： 本发明涉及固相肽合成。 固相肽合成在聚丙烯酸树脂（例如分别对应于美国专利号4,436,874和4,439,545的EP 0 079 812和EP 0 081 408中描述的那些）中完成，方法包括在洗涤 在水和/或水溶液中的树脂。

    Peptide-mediated transfection agents and methods of use
    4.
    发明授权
    Peptide-mediated transfection agents and methods of use 有权
    肽介导的转染剂和使用方法

    公开(公告)号：US06841535B2

    公开(公告)日：2005-01-11

    申请号：US09915914

    申请日：2001-07-26

    申请人： Gilles Divita ,  May C. Morris ,  Jean Mery ,  Frederic Heitz ,  Joseph Fernandez ,  John Archdeacon ,  Kyle Horndorp

    发明人： Gilles Divita ,  May C. Morris ,  Jean Mery ,  Frederic Heitz ,  Joseph Fernandez ,  John Archdeacon ,  Kyle Horndorp

    IPC分类号： A61K47/48 ,  C07K7/08 ,  C07K14/00 ,  C12N15/87 ,  A61K38/10

    CPC分类号： C07K7/08 ,  A61K47/64 ,  C07K14/001 ,  C12N15/87

    摘要： Peptides that are useful as transfection agents are described. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell. Advantages include but are not limited to excellent transfection efficiency, relatively low toxicity, internalization by a broad host cell spectrum, and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered. Applications include but are not limited to the delivery of diagnostics and therapeutics, as well as drug discovery, gene discovery, and the analysis and/or manipulation of other cellular and molecular biological functions. Claims are made for transfection agents, compositions of matter, including pharmaceutical compositions, reagent kits, methods of delivery, and methods of identification of additional peptides for performing and/or including in the same.

    摘要翻译： 描述了可用作转染剂的肽。 这些肽可以促进广泛范围和大小的化合物的有效细胞内化，当与其非共价复合时可有效地内化到细胞中。 优点包括但不限于优异的转染效率，相对低的毒性，广泛的宿主细胞谱的内化，以及不必将肽与待递送的特定分子共价复合而产生的简单性和成本效益。 应用包括但不限于诊断和治疗的传递，以及药物发现，基因发现以及其他细胞和分子生物功能的分析和/或操作。 对于转染剂，物质组合物，包括药物组合物，试剂盒，递送方法以及用于鉴定用于进行和/或包含在其中的另外的肽的方法而提出要求。