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1.发明授权Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan derivatives and pharmaceutical compositions therefor 失效脂氧合酶和环化酶抑制thiromromen和thiepan衍生物及其药物组合物
公开(公告)号：US4699919A
公开(公告)日：1987-10-13
申请号：US908407
申请日：1986-09-16
申请人： Michel Follet , Marc Bonato
发明人： Michel Follet , Marc Bonato
IPC分类号： C12N9/99 , A61K31/095 , A61K31/10 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/38 , A61K31/382 , A61K45/06 , A61P7/02 , A61P7/06 , A61P9/08 , A61P9/10 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/20 , C07C323/45 , C07C323/62 , C07D335/04 , C07D335/06 , C07D337/08 , C07D337/12 , C07D521/00
CPC分类号： C07D335/06 , A61K31/10 , C07C323/00 , C07D337/08
摘要： This invention relates to bicyclic catechol derivatives having the general formulae I and II ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and Z represent various substituents, to a preparation process of the same comprising reacting a compound of formula III ##STR2## wherein R.sub.1 and R.sub.2 have the meanings given above with an appropriately substituted propionic or butyric acid (or an ester or a salt of the same) of formula IV ##STR3## wherein R.sub.3 has the meaning given above, and to therapeutical compositions wherein the active ingredient is one of these compounds.
摘要翻译： 本发明涉及具有通式I和II的双环类邻苯二酚衍生物，其中R1，R2，R3和Z代表各种取代基，涉及其制备方法，包括使式III化合物
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2.发明授权Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation 失效用于合成（R） - 桑索罗辛及其药学上可接受的盐的中间体及其制备方法公开(公告)号：US07619116B2
公开(公告)日：2009-11-17
申请号：US10583472
申请日：2004-12-15
申请人： Valéry Dambrin , Jean-Yves Lenoir , Jean-Marie Schneider , Gérard Guillamot , Michel Follet , Abram Becker
发明人： Valéry Dambrin , Jean-Yves Lenoir , Jean-Marie Schneider , Gérard Guillamot , Michel Follet , Abram Becker
IPC分类号： C07C211/08
CPC分类号： C07C323/67 , C07C303/40 , C07C311/37 , C07C311/46 , C07C319/20 , C07D263/06 , C07D263/14 , C07D263/24 , C07D277/04 , C07D277/10 , C07D277/14 , Y02P20/55
摘要： A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
摘要翻译： 本发明的主题是用于合成（R） - 桑索罗辛及其药学上可接受的盐的新型中间体，以及相关的制备方法。
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3.发明授权Acrylic copolymers of N-acryloylpolymethyleneimines or N-acryloyldialkylamides, N,N'-acryloyldiaminoalcanes and N-acryloylaminoacids (or esters) their preparation and use as cation exchangers 失效N-丙烯酰聚亚甲基亚胺或N-丙烯酰基二烷基酰胺的丙烯酸共聚物，N，N'-丙烯酰基二氨基乙烷和N-丙烯酰氨基酸（或酯）的制备和用作阳离子交换剂
公开(公告)号：US4439545A
公开(公告)日：1984-03-27
申请号：US440441
申请日：1982-11-10
申请人： Christian Aspisi , Bernard Calas , Jacques Daunis , Michel Follet , Robert Jacquier , Joseph Parello
发明人： Christian Aspisi , Bernard Calas , Jacques Daunis , Michel Follet , Robert Jacquier , Joseph Parello
IPC分类号： C08F220/56 , B01J39/20 , B01J39/26 , C07K1/04 , C07K1/06 , C07K1/10 , C08F2/10 , C08F2/32 , C08F8/00 , C08F8/12 , C08F8/32 , C08F20/00 , C08F20/52 , C08F220/54 , C08F220/58 , C08F220/60
CPC分类号： C08F220/54 , B01J39/20 , B01J39/26 , C07K1/042 , C08F8/32
摘要： The invention relates to new reticulated statistic acrylic copolymers that may be used in a very wide range of solvents (water, methylene chloride, chloroform, methanol, ethanol, dimethylformamide, pyridine,) stable between pH 1 and pH 14, to preparation process thereof and to their use in ion exchange chromatography.
摘要翻译： 本发明涉及新的网状统计丙烯酸共聚物，其可用于非常广泛的溶液（水，二氯甲烷，氯仿，甲醇，乙醇，二甲基甲酰胺，吡啶）在pH 1和pH 14之间稳定的溶剂，其制备方法和 用于离子交换层析。
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4.发明申请Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation 失效用于合成（r）坦洛新及其药学上可接受的盐的新型中间体及其制备方法公开(公告)号：US20070106079A1
公开(公告)日：2007-05-10
申请号：US10583472
申请日：2004-12-15
申请人： Valéry Dambrin , Jean-Yves Lenoir , Jean-Marie Schneider , Gerard Guillamot , Michel Follet , Abram Becker
发明人： Valéry Dambrin , Jean-Yves Lenoir , Jean-Marie Schneider , Gerard Guillamot , Michel Follet , Abram Becker
IPC分类号： C07D277/04 , C07D263/02
CPC分类号： C07C323/67 , C07C303/40 , C07C311/37 , C07C311/46 , C07C319/20 , C07D263/06 , C07D263/14 , C07D263/24 , C07D277/04 , C07D277/10 , C07D277/14 , Y02P20/55
摘要： A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
摘要翻译： 本发明的主题是用于合成（R） - 桑索罗辛及其药学上可接受的盐的新型中间体，以及相关的制备方法。
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公开(公告)号：US4436874A
公开(公告)日：1984-03-13
申请号：US440440
申请日：1982-11-10
申请人： Christian Aspisi , Bernard Calas , Jacques Daunis , Michel Follet , Robert Jacquier , Joseph Parello
发明人： Christian Aspisi , Bernard Calas , Jacques Daunis , Michel Follet , Robert Jacquier , Joseph Parello
IPC分类号： C08F220/56 , B01J39/20 , B01J39/26 , C07K1/04 , C07K1/06 , C07K1/10 , C08F2/10 , C08F2/32 , C08F8/00 , C08F8/12 , C08F8/32 , C08F20/00 , C08F20/52 , C08F220/54 , C08F220/58 , C08F220/60 , B01J31/08
CPC分类号： C08F220/54 , B01J39/20 , B01J39/26 , C07K1/042 , C08F8/32
摘要： The present invention relates to new amino-functionalized acrylic copolymers, their preparation and their use in peptide synthesis.
摘要翻译： 本发明涉及新的氨基官能化丙烯酸共聚物，其制备及其在肽合成中的应用。
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6.发明授权Solid phase peptide synthesis using a polyacrylic support in aqueous solution 失效在水溶液中使用聚丙烯酸载体的固相肽合成
公开(公告)号：US5175254A
公开(公告)日：1992-12-29
申请号：US766899
申请日：1991-09-26
申请人： Bernard Calas , Jean Mery , Hanitra Naharisoa , Michel Follet
发明人： Bernard Calas , Jean Mery , Hanitra Naharisoa , Michel Follet
IPC分类号： C07K1/04
CPC分类号： C07K1/04
摘要： This invention relates to solid phase peptide synthesis.Solid phase peptide synthesis is accomplished on polyacrylic resins (such as those described in EP 0 079 812 and EP 0 081 408 which correspond to U.S. Pat. Nos. 4,436,874 and 4,439,545 respectively) by a method which includes in the coupling protocol steps of washing the resin in water and/or aqueous solution(s).
摘要翻译： 本发明涉及固相肽合成。 固相肽合成在聚丙烯酸树脂（例如分别对应于美国专利号4,436,874和4,439,545的EP 0 079 812和EP 0 081 408中描述的那些）中完成，方法包括在洗涤 在水和/或水溶液中的树脂。
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7.发明授权Catechol derivatives, a process of preparation thereof, and therapeutical compositions containing the same 失效儿茶酚衍生物，其制备方法和含有它们的治疗组合物
公开(公告)号：US5013756A
公开(公告)日：1991-05-07
申请号：US356568
申请日：1989-05-23
申请人： Michel Follet , Marc Bonato
发明人： Michel Follet , Marc Bonato
IPC分类号： C12N9/99 , A61K31/095 , A61K31/10 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/38 , A61K31/382 , A61K45/06 , A61P7/02 , A61P7/06 , A61P9/08 , A61P9/10 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/20 , C07C323/45 , C07C323/62 , C07D335/04 , C07D335/06 , C07D337/08 , C07D337/12 , C07D521/00
CPC分类号： C07D335/06 , A61K31/10 , C07C323/00 , C07D337/08
摘要： This invention relates to catechol derivatives having the general formula ##STR1## wherein R represents various substituents, to a process for the preparation of the same comprising reacting S-(3,4-dihydroxyphenyl)-isothiourea, which has the formula II, with a tosylate of the general formula III ##STR2## and to therapeutical compositions wherein the active ingredient is one of these compounds.
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