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    N-Substituted-1-aminoalkyl-1,4-dihydropyridines
    9.
    发明授权
    N-Substituted-1-aminoalkyl-1,4-dihydropyridines 失效
    N-取代的-1-氨基烷基-1,4-二氢吡啶

    公开(公告)号：US4472584A

    公开(公告)日：1984-09-18

    申请号：US471959

    申请日：1983-03-03

    申请人： Bernard Loev ,  Howard Jones ,  John T. Suh

    发明人： Bernard Loev ,  Howard Jones ,  John T. Suh

    IPC分类号： C07D211/90 ,  C07D211/82 ,  A61K31/455 ,  C07D401/04 ,  C07D405/04

    CPC分类号： C07D211/90

    摘要： Compounds of the formula: ##STR1## wherein Ar is heteroaryl, cycloalkyl having from 3 to 7 carbon atoms, naphthyl, indanyl, indenyl, tetrahydro naphthyl, or a radical of the formula ##STR2## wherein each of R.sub.5, R.sub.6 and R.sub.7 is independently H, alkyl, aryl, halo, lower alkoxy, nitro, amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, acyloxy, methanesulfonyl, alkylamino or acylamino; and R.sub.5 and R.sub.6 when taken together, form a methylenedioxy; Z is alkylene containing 1 to about 5 carbon atoms in the principal chain; each R.sub.1 is independently hydrogen, alkyl or alkoxyalkyl, with the proviso that only one R.sub.1 may be hydrogen; R.sub.2 is lower alkyl; R.sub.3 is hydroxyalkyl containing 2 to 4 carbon atoms and R.sub.4 is H, alkyl, cycloalkyl or hydroxyalkyl containing 2 to 4 carbon atoms; wherein the alkyl, alkoxy, and acyl groups contain up to 10 carbon atoms, and their pharmaceutically-acceptable salts are disclosed. These compounds have anti-hypertensive activity.

    摘要翻译： 下式的化合物：其中Ar是杂芳基，具有3至7个碳原子的环烷基，萘基，茚满基，茚基，四氢萘基或下式的基团其中R 5，R 6和R 7各自独立地是 H，烷基，芳基，卤素，低级烷氧基，硝基，氨基，烷基巯基，氰基，羧基，烷氧基，氨基磺酰基，三氟甲基，羟基，酰氧基，甲磺酰基，烷基氨基或酰基氨基; 并且R 5和R 6一起形成亚甲二氧基; Z是主链中含有1至约5个碳原子的亚烷基; 每个R 1独立地是氢，烷基或烷氧基烷基，条件是只有一个R 1可以是氢; R2是低级烷基; R3是含有2至4个碳原子的羟基烷基，R4是H，含2至4个碳原子的烷基，环烷基或羟基烷基; 其中烷基，烷氧基和酰基含有至多10个碳原子，并且公开了它们的药学上可接受的盐。 这些化合物具有抗高血压活性。

    Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses
    10.
    发明授权
    Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses 失效
    用于治疗牛皮癣和过敏反应的α-烷基聚烯烃羧酸及其衍生物

    公开(公告)号：US4694023A

    公开(公告)日：1987-09-15

    申请号：US710768

    申请日：1985-03-11

    申请人： Bernard Loev ,  Wan-kit Chan ,  Howard Jones

    发明人： Bernard Loev ,  Wan-kit Chan ,  Howard Jones

    IPC分类号： A61K31/16 ,  A61K31/20 ,  A61K31/23 ,  C07C403/00 ,  C07C57/03

    CPC分类号： A61K31/23 ,  A61K31/16 ,  A61K31/20 ,  C07C403/20 ,  C07C2101/16

    摘要： Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

    摘要翻译： 由通式“IMAGE”表示的聚烯烃化合物，其中R和R 1各自为氢或1至5个碳原子的烷基; R2是1至5个碳原子的烷基; R3是羟基，1至5个碳原子的烷氧基，NH2，NHR2或NR2R2，Z是被0-5个烷基取代的环烷基，环烯基或环二烯基，酮基或羟基或被 0至4个羟基，烷氧基，烷基或三氟甲基或卤素原子或其组合及其药学上可接受的盐。 已经发现前述化合物在治疗牛皮癣，炎性病症和过敏反应方面是有效的。