-
1.发明申请公开(公告)号：US20210246170A1
公开(公告)日：2021-08-12
申请号：US17163357
申请日：2021-01-30
发明人： Johannes Petrus Maria LANGEDIJK , Lucy RUTTEN , Mark Johannes Gerardus BAKKERS , Rinke BOS , Frank WEGMANN , David Adrianus Theodorus Maria ZUIJDGEEST , Dan H. BAROUCH , An VANDEBOSCH , Mathieu Claude Michel le GARS , Jerald C. SADOFF
IPC分类号： C07K14/005 , A61P31/14 , C12N7/00 , C12N15/86 , A61K39/215
摘要： The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines.
-
2.发明申请STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING SAME 有权稳定的人体免疫缺陷病毒（HIV）环境（ENV）TRIMER疫苗及其使用方法公开(公告)号：US20140302080A1
公开(公告)日：2014-10-09
申请号：US14149549
申请日：2014-01-07
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/162 , C12N2740/16034 , C12N2740/16111
摘要： The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
摘要翻译： 本发明具有稳定的人类免疫缺陷病毒（HIV）包膜（Env）三聚体。 本发明还具有用于递送和/或促进稳定的HIV Env三聚体生产的疫苗，核酸和载体。 此外，本发明的特征在于制备和使用本发明的稳定的HIV环境三聚体的方法。
-
3.发明申请公开(公告)号：US20230075527A1
公开(公告)日：2023-03-09
申请号：US17759803
申请日：2021-01-30
发明人： Dan H. BAROUCH , Johannes Petrus Maria LANGEDIJK , Lucy RUTTEN , Mark Johannes Gerardus BAKKERS , Rinke BOS , Frank WEGMANN , David Adrianus Theodorus Maria ZUIJDGEEST , An VANDEBOSCH , Mathieu Claude Michel LE GARS , Jerald C. SADOFF
IPC分类号： A61K39/215 , A61P31/14
摘要： The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines.
-
4.发明申请公开(公告)号：US20200055901A1
公开(公告)日：2020-02-20
申请号：US16342866
申请日：2017-10-17
IPC分类号： C07K14/005 , A61K39/21 , C07K16/10 , A61K47/68 , A61P31/18
摘要： The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
-
公开(公告)号：US20190136205A1
公开(公告)日：2019-05-09
申请号：US16159336
申请日：2018-10-12
发明人： Dan H. BAROUCH , Herbert VIRGIN, IV , Peter ABBINK
摘要： The present invention relates to recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are novel simian adenoviruses having a low seroprevalence and high immunogenicity relative to other adenoviruses and vectors thereof. The invention also provides methods for production of the adenoviruses and for the treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
-
公开(公告)号：US20210206838A1
公开(公告)日：2021-07-08
申请号：US17057444
申请日：2019-05-22
发明人： Dan H. BAROUCH , Bruce A. KERWIN , Randal R. KETCHEM , Alison J. GILLESPIE , Christine C. SISKA , Rutilio H. CLARK , Julee A. FLOYD , Jeremy M. SHAVER , Richard S. ROGERS
摘要： Featured are PGT121 variant antibodies or fragments thereof, which can be administered, e.g., as antibody therapies for treating human immunodeficiency virus (HIV) infection. In particular, featured are methods of treating subjects infected with HIV and/or blocking HIV infections in subjects at risk of HIV transmission using the PGT121 variant antibodies or fragments thereof.
-
公开(公告)号：US20190314492A1
公开(公告)日：2019-10-17
申请号：US16441703
申请日：2019-06-14
IPC分类号： A61K39/21 , A61K39/275 , C12N7/00 , A61K39/235 , A61K39/12 , C07K14/005
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
-
公开(公告)号：US20190144506A1
公开(公告)日：2019-05-16
申请号：US16099254
申请日：2017-06-09
发明人： Dan H. BAROUCH , Peter ABBINK , Rafael LAROCCA
IPC分类号： C07K14/005 , C07K16/10 , A61P31/14
摘要： The invention relates to immunogenic compositions and vaccines containing a ZIKV protein or a polynucleotide encoding a Zika virus (ZIKV) protein and uses thereof. The invention also provides methods of treating and/or preventing a ZiKV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
-
公开(公告)号：US20240287142A1
公开(公告)日：2024-08-29
申请号：US18455151
申请日：2023-08-24
IPC分类号： C07K14/075 , A61K31/7088 , A61K35/761 , A61K39/235 , C07K14/54 , C12N15/861
CPC分类号： C07K14/075 , A61K31/7088 , A61K35/761 , A61K39/235 , C07K14/5425 , C12N15/861
摘要： Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
-
10.发明申请公开(公告)号：US20190055290A1
公开(公告)日：2019-02-21
申请号：US16177573
申请日：2018-11-01
IPC分类号： C07K14/005 , A61K39/21 , A61K39/12 , C07K14/16 , A61K39/00
摘要： The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.022 秒)
