公开(公告)号：US20140263011A1

公开(公告)日：2014-09-18

申请号：US14115238

申请日：2012-05-03

申请人： Bhaktavachalam Thiyagarajan ,  Wei Guo ,  Nandu Deorkar

发明人： Bhaktavachalam Thiyagarajan ,  Wei Guo ,  Nandu Deorkar

IPC分类号： B01D15/20

摘要： Chromatographic media of porous media particles derivatized with allylamine or polyallylamine obtained directly or through intermolecular polymerization on the surface thereof and such media functionalized with further functionalization groups. Such media are particularly useful for separating biomolecules.

摘要翻译： 通过直接或通过其表面上的分子间聚合获得的烯丙胺或聚烯丙基胺衍生的多孔介质颗粒的色谱介质和用另外的官能团官能化的介质。 这种培养基特别适用于分离生物分子。

公开(公告)号：US20120283419A1

公开(公告)日：2012-11-08

申请号：US13373064

申请日：2011-11-03

申请人： Bhaktavachalam Thiyagarajan ,  Wei Guo ,  Nandu Deorkar

发明人： Bhaktavachalam Thiyagarajan ,  Wei Guo ,  Nandu Deorkar

IPC分类号： C07K1/18 ,  C07K16/00

CPC分类号： C07K16/065 ,  C07K5/0215

摘要： A flow-through process for separating protein monomer from aggregates of that protein in a solution containing both protein monomer and aggregates of that protein, the process includes the steps of1) contacting the solution at a pH of from 4 to 7 with a weak anion exchange media comprised of multiple primary, secondary and/or tertiary amine functionalization groups whereby the protein monomer flows through the media without binding thereto and the aggregates are retained on the media, and2) collecting the flow-through as purified protein monomer.

摘要翻译： 一种用于在含有蛋白质单体和蛋白质的聚集体的溶液中分离蛋白质单体与该蛋白质的聚集体的流通过程，该方法包括以下步骤：1）将pH为4至7的溶液与弱阴离子 由多个伯胺，仲胺和/或叔胺官能化基团组成的交换介质，由此蛋白质单体流过培养基而不与其结合，聚集体保留在培养基上，和2）以纯化的蛋白质单体收集流通。

公开(公告)号：US20100261842A1

公开(公告)日：2010-10-14

申请号：US11521246

申请日：2006-09-14

申请人： Nandu Deorkar ,  Steve Magee ,  Wei Guo

发明人： Nandu Deorkar ,  Steve Magee ,  Wei Guo

IPC分类号： C08H1/00 ,  C07K1/22

CPC分类号： C07K14/31 ,  C12N1/20

摘要： Purification of vegetarian (non-animal derived) Protein A using a multidimensional purification process to remove undesirable non-animal derived component impurities in the Protein A from the non-animal fermentation media used to produce the Protein A so as to produce a vegetarian Protein A free of animal-origin components and essentially free of components derived from non-animal derived growth media.

摘要翻译： 使用多维纯化方法纯化素食（非动物衍生的）蛋白A，以从用于产生蛋白A的非动物发酵培养基中除去蛋白A中的不需要的非动物衍生成分杂质，从而产生素蛋白A 没有动物来源的组分，并且基本上不含源自非动物来源的生长培养基的组分。

公开(公告)号：US08929021B1

公开(公告)日：2015-01-06

申请号：US13431680

申请日：2012-03-27

申请人： Jiangang Liang ,  Wei Guo

发明人： Jiangang Liang ,  Wei Guo

IPC分类号： G11B5/596 ,  G11B27/32

CPC分类号： G11B20/14 ,  G11B20/10222 ,  G11B27/32

摘要： A disk drive is disclosed comprising a head actuated over a disk comprising a plurality of spiral tracks, wherein each spiral track comprising a high frequency signal interrupted at a predetermined interval by a sync mark. An offset r0 representing a difference between an axial rotation of the disk and an axial rotation of the spiral tracks is estimated. Radial dependent timing compensation values are generated in response to the estimated r0. A phase error is generated in response to the sync marks in the spiral track crossings. A control signal is generated in response to the phase error and the radial dependent timing compensation values, and a frequency of an oscillator is adjusted in response to the control signal.

摘要翻译： 公开了一种磁盘驱动器，包括在包括多个螺旋轨道的盘上致动的磁头，其中每个螺旋轨道包括以预定间隔以同步标记中断的高频信号。 估计表示盘的轴向旋转与螺旋轨迹的轴向旋转之间的差异的偏移r​​0。 响应于估计的r0产生径向相关定时补偿值。 响应于螺旋轨道交叉中的同步标记产生相位误差。 响应于相位误差和与径向相关的定时补偿值产生控制信号，并且响应于控制信号调整振荡器的频率。

公开(公告)号：US08883841B2

公开(公告)日：2014-11-11

申请号：US12094739

申请日：2006-11-22

申请人： Bingliang Fang ,  Jinsong Liu ,  Wei Guo ,  Shuhong Wu

发明人： Bingliang Fang ,  Jinsong Liu ,  Wei Guo ,  Shuhong Wu

IPC分类号： A61K31/404

CPC分类号： A61K31/404

摘要： Embodiments of the present invention provide for methods and compositions comprising an Oncorasin, such as 1-[(4-chlorophenyl)methyl]-1H-Indole-3-carboxaldehyde (oncrasin-1) and/or its analogs or derivatives.

摘要翻译： 本发明的实施方案提供包含Oncorasin，例如1 - [（4-氯苯基）甲基] -1H-吲哚-3-甲醛（oncrasin-1）和/或其类似物或衍生物的方法和组合物。

公开(公告)号：US20130149392A1

公开(公告)日：2013-06-13

申请号：US13316878

申请日：2011-12-12

申请人： Wei Guo ,  Vojo Vukovic

发明人： Wei Guo ,  Vojo Vukovic

IPC分类号： A61K31/167 ,  A61P35/04 ,  A61K31/475 ,  A61K33/24 ,  A61K31/7068 ,  A61K31/519 ,  A61P35/00 ,  A61K31/337

CPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/337 ,  A61K31/439 ,  A61K31/706 ,  A61K2300/00

摘要： The present invention is a method for treating non-small cell lung cancer in a subject in need thereof, comprising administering to the subject an effective amount of a bis(thiohydrazideamide) compound of formula (I): wherein the variables are defined herein. Furthermore, pharmaceutical compositions, combination therapies, and uses thereof are also provided in the present application.

摘要翻译： 本发明是在有需要的受试者中治疗非小细胞肺癌的方法，其包括对受试者施用有效量的式（I）的双（硫代酰肼）酰化物：其中变量在本文中定义。 此外，本申请中还提供了药物组合物，组合疗法及其用途。

公开(公告)号：US20120168669A1

公开(公告)日：2012-07-05

申请号：US12983534

申请日：2011-01-03

申请人： Yong CHE ,  Makoto Murakami ,  Wei Guo

发明人： Yong CHE ,  Makoto Murakami ,  Wei Guo

IPC分类号： C04B35/00 ,  B29B9/02 ,  B32B5/16

CPC分类号： C04B35/62695 ,  B22F1/0018 ,  B22F1/02 ,  B22F9/04 ,  B22F2999/00 ,  B82Y30/00 ,  C01G49/04 ,  C01G49/08 ,  C01P2004/04 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2004/80 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/5454 ,  C09C1/62 ,  C22C29/00 ,  C22C32/00 ,  H01F1/0054 ,  Y10T428/2982 ,  Y10T428/2991 ,  B22F2202/11

摘要： A composite nanoparticle, for example a nanoparticle containing one or a plurality of cores embedded in another material. A composite nanoparticle can be formed by a one step process that includes: ejecting material from a bulk target material using physical energy source, with the bulk target material disposed in a liquid. Composite nanoparticles are formed by cooling at least a portion of the ejected material in the liquid. The composite fine particles may then be collected from the liquid. A product that includes composite fine particles may be formed with laser ablation, and ultrashort laser ablation may be utilized so as to preserve composite nanoparticle stoichiometry. For applications of the composite fine particles, optical properties and/or magnetic properties may be exploited for various applications.

摘要翻译： 复合纳米颗粒，例如含有嵌入另一材料中的一个或多个芯的纳米颗粒。 复合纳米颗粒可以通过一步法形成，该方法包括：使用物理能源从大量目标材料中喷射材料，其中大量目标材料设置在液体中。 复合纳米颗粒通过冷却至少一部分喷射的液体中的材料形成。 然后可以从液体中收集复合细颗粒。 可以通过激光烧蚀形成包括复合细颗粒的产品，并且可以利用超短激光烧蚀以保持复合纳米颗粒的化学计量。 对于复合细颗粒的应用，可以利用光学性质和/或磁性来进行各种应用。

公开(公告)号：US20100123703A1

公开(公告)日：2010-05-20

申请号：US12590756

申请日：2009-11-13

申请人： Wei Guo ,  Sha Feng

发明人： Wei Guo ,  Sha Feng

IPC分类号： G09G5/00

CPC分类号： G09G3/3648 ,  G09G2310/067 ,  G09G2320/0223 ,  G09G2320/0247 ,  G09G2330/02

摘要： A driving circuit for a liquid crystal display includes a gate driver configured for generating scanning signals, a power circuit configured for providing an operating voltage to the gate driver, a timing controller configured for providing a clock signal having a variable frequency, and a voltage adjusting circuit located between the power circuit and the gate driver, for adjusting the operating voltage applied to the gate driver under control of the timing controller. Waveforms of the scanning signals include cutting angles corresponding to the variable frequency of the clock signal.

摘要翻译： 一种用于液晶显示器的驱动电路，包括用于产生扫描信号的栅极驱动器，被配置为向栅极驱动器提供工作电压的电源电路，被配置为提供具有可变频率的时钟信号和电压调节 位于电源电路和栅极驱动器之间的电路，用于在时序控制器的控制下调节施加到栅极驱动器的工作电压。 扫描信号的波形包括与时钟信号的可变频率对应的切割角度。

公开(公告)号：US20090299757A1

公开(公告)日：2009-12-03

申请号：US12508103

申请日：2009-07-23

申请人： Wei Guo ,  Peilin Liu ,  Wei Li ,  Lijing Xu ,  Qing Zhang ,  Jainfeng Xu ,  Shenghu Sang ,  Zhengzhong Du ,  Chen Hu

发明人： Wei Guo ,  Peilin Liu ,  Wei Li ,  Lijing Xu ,  Qing Zhang ,  Jainfeng Xu ,  Shenghu Sang ,  Zhengzhong Du ,  Chen Hu

IPC分类号： G10L19/00

CPC分类号： G10L19/18 ,  G10L19/0212 ,  G10L19/022 ,  G10L19/04

摘要： An method for encoding comprising: obtaining, according to a data length of a first overlapped portion between encoding data of a current frame and encoding data of a previous frame, first encoding data corresponding to the data length of the first overlapped portion from the previous frame, if the previous frame is encoded in a first encoding mode and the current frame is to be encoded in a second encoding mode; and encoding, in the second encoding mode, the first encoding data corresponding to the data length of the first overlapped portion from the previous frame and encoding data of the current frame. The corresponding decoding method, encoding and decoding apparatuses are also disclosed.

摘要翻译： 一种用于编码的方法，包括：根据当前帧的编码数据与前一帧的编码数据之间的第一重叠部分的数据长度获得与来自前一帧的第一重叠部分的数据长度相对应的第一编码数据 如果先前帧以第一编码模式编码并且当前帧将以第二编码模式编码; 以及在第二编码模式中，对应于来自前一帧的第一重叠部分的数据长度的第一编码数据和当前帧的编码数据进行编码。 还公开了相应的解码方法，编码和解码装置。

公开(公告)号：US20090168232A1

公开(公告)日：2009-07-02

申请号：US12006329

申请日：2007-12-31

申请人： Wei Guo ,  Xiaoping Hu

发明人： Wei Guo ,  Xiaoping Hu

IPC分类号： G11B5/596

CPC分类号： G11B5/5552

摘要： A microactuator reference limit used to prevent over-accumulation of internal states may be set based on the microactuator's mechanical properties and is applied at the reference point to the microactuator servo subsystem. A microactuator variable input limit to prevent over-accumulation of internal states may be dynamically determined based on the difference between a signal corresponding to the maximum physical stroke of the microactuator and an estimated motion of the microactuator. Either configuration of servo system automatically ensures that all the internal states of the microactuator controller will not over-react and cause excessive overshoot, sluggish response, and/or saturation.