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公开(公告)号：US09080152B2
公开(公告)日：2015-07-14
申请号：US13254039
申请日：2009-04-30
IPC: A61K39/12 , A61K39/02 , A61K45/06 , C12N5/0783 , A61K35/12
CPC classification number: C12N5/0636 , A61K2035/124 , C12N2501/515 , C12N2510/00
Abstract: Methods for expansion of antigen-specific T cells are provided. Said methods include following steps: generating antigen-specific T cells by stimulation of T cells with antigen A; introducing genes encoding immune recognition molecule specific to major histocompatibility complex (MHC) molecule bound with a peptide derived from antigen B into the antigen A specific T cell to produce bi-specific T cells recognizing both target cells expressing antigen A peptide associated MHC and target cells expressing antigen B peptide associated MHC; stimulating the bi-specific T cells by antigen A for expansion of the bi-specific T cells in vitro or in vivo. Methods of the present invention can be applied to expand various of T cells with specific to cancer cells with tumor antigen peptide loaded MHC molecules for adoptive therapy against unmet medical need such as tumors etc.
Abstract translation: 提供了用于扩增抗原特异性T细胞的方法。 所述方法包括以下步骤：通过用抗原A刺激T细胞产生抗原特异性T细胞; 引入编码针对与源自抗原B的肽结合的主要组织相容性复合物（MHC）分子特异性的免疫识别分子的基因进入抗原A特异性T细胞，以产生识别表达抗原A肽相关MHC和靶细胞的两种靶细胞的双特异性T细胞 表达抗原B肽相关MHC; 通过抗原A刺激双特异性T细胞以在体外或体内扩增双特异性T细胞。 本发明的方法可应用于扩增具有癌细胞特异性的各种具有肿瘤抗原肽的MHC分子的T细胞用于针对未满足的医疗需要如肿瘤等的过继疗法。
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公开(公告)号：US20120100180A1
公开(公告)日：2012-04-26
申请号：US13254039
申请日：2009-04-03
CPC classification number: C12N5/0636 , A61K2035/124 , C12N2501/515 , C12N2510/00
Abstract: Methods for expansion of antigen-specific T cells are provided. Said methods include following steps: generating antigen-specific T cells by stimulation of T cells with antigen A; introducing genes encoding immune recognition molecule specific to major histocompatibility complex (MHC) molecule bound with a peptide derived from antigen B into the antigen A specific T cell to produce bi-specific T cells recognizing both target cells expressing antigen A peptide associated MHC and target cells expressing antigen B peptide associated MHC; stimulating the bi-specific T cells by antigen A for expansion of the bi-specific T cells in vitro or in vivo. Methods of the present invention can be applied to expand various of T cells with specific to cancer cells with tumor antigen peptide loaded MHC molecules for adoptive therapy against unmet medical need such as tumors etc.
Abstract translation: 提供了用于扩增抗原特异性T细胞的方法。 所述方法包括以下步骤：通过用抗原A刺激T细胞产生抗原特异性T细胞; 引入编码针对与源自抗原B的肽结合的主要组织相容性复合物（MHC）分子特异性的免疫识别分子的基因进入抗原A特异性T细胞，以产生识别表达抗原A肽相关MHC和靶细胞的两种靶细胞的双特异性T细胞 表达抗原B肽相关MHC; 通过抗原A刺激双特异性T细胞以在体外或体内扩增双特异性T细胞。 本发明的方法可应用于扩增具有癌细胞特异性的各种具有肿瘤抗原肽的MHC分子的T细胞用于针对未满足的医疗需要如肿瘤等的过继疗法。
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3.发明授权Resistive-switching device capable of implementing multiary addition operation and method for multiary addition operation 有权能够实现多重加法运算的电阻式开关装置及多次加法运算方法公开(公告)号：US08929123B2
公开(公告)日：2015-01-06
申请号：US13641832
申请日：2011-11-18
Applicant: Jinfeng Kang , Feifei Zhang , Bin Gao , Bing Chen , Lifeng Liu , Xiaoyan Liu
Inventor： Jinfeng Kang , Feifei Zhang , Bin Gao , Bing Chen , Lifeng Liu , Xiaoyan Liu
CPC classification number: G11C13/0007 , G11C11/5685 , G11C13/0069 , G11C2013/0073 , G11C2013/0083
Abstract: The present disclosure provides a resistive-switching device capable of implementing multiary addition operation and a method for implementing multiary addition operation using the resistive-switching device. The resistive-switching device has a plurality of resistance values each corresponding to a respective data value stored by the resistive-switching device and ranging from a high resistance value to a low resistance value. The data value stored by the resistive-switching device is increased by ‘1’ successively with a series of set pulses having a same pulse width and a same voltage amplitude being applied thereto. The data value stored by the resistive-switching device is set to ‘0’ with a reset pulse being applied thereto, and meanwhile a data value stored by a higher-bit resistive-switching device is increased by ‘1’ with a set pulse being applied thereto. In this way, multiary addition operation is implemented.
Abstract translation: 本公开提供了一种能够实现多加法运算的电阻式开关装置和使用电阻式开关装置实现多重加法运算的方法。 电阻开关器件具有多个电阻值，每个电阻值对应于由电阻开关器件存储的各个数据值，并且从高电阻值到低电阻值。 由电阻式开关器件存储的数据值以相同的脉冲宽度和相同的电压幅度施加一系列设定脉冲连续增加“1”。 由施加复位脉冲的电阻开关器件存储的数据值被设定为“0”，同时由高位电阻开关器件存储的数据值增加“1”，设定脉冲为 应用于此。 以这种方式，实现多重添加操作。
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公开(公告)号：US08924321B2
公开(公告)日：2014-12-30
申请号：US13502462
申请日：2011-11-03
Applicant: Jinfeng Kang , Bin Gao , Feifei Zhang , Bing Chen , Lifeng Liu , Xiaoyan Liu
Inventor： Jinfeng Kang , Bin Gao , Feifei Zhang , Bing Chen , Lifeng Liu , Xiaoyan Liu
CPC classification number: G06N3/063
Abstract: A neuron device includes a bottom electrode, a top electrode, and a layer of metal oxide variable resistance material sandwiched between the bottom electrode and the top electrode, in which the neuron device is switched to a normal state upon application of reset pulse, and is switched to an excitation state upon application of stimulus pulses. The neuron device has a comprehensive response to different amplitude, different width of a stimulus voltage pulse and different number of a sequence of stimulus pulses, and provides functionalities of a weighting section and a computing section. The neuron device has a simple structure, excellent scalability, quick speed, low operation voltage, and is compatible with the conventional silicon-based CMOS fabrication process, and thus suitable for mass production. The neuron device is capable of performing many biological functions and complex logic operations.
Abstract translation: 神经元装置包括底部电极，顶部电极和夹在底部电极和顶部电极之间的金属氧化物可变电阻材料层，其中神经元装置在施加复位脉冲时切换到正常状态，并且是 在施加刺激脉冲时切换到激发状态。 神经元装置对刺激电压脉冲的不同幅度，不同宽度和不同数量的刺激脉冲序列具有综合响应，并提供加权部分和计算部分的功能。 神经元器件结构简单，可扩展性好，速度快，工作电压低，与传统的硅基CMOS制造工艺兼容，适合批量生产。 神经元器件能够执行许多生物学功能和复杂的逻辑运算。
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公开(公告)号：US20130197993A1
公开(公告)日：2013-08-01
申请号：US13358955
申请日：2012-01-26
Applicant: Bin Gao , Tie-Yan Liu
Inventor： Bin Gao , Tie-Yan Liu
CPC classification number: G06Q30/0275 , G06Q30/0244
Abstract: In a system that supports paid advertisements, as advertisements are awarded ad spots based on contextual relevance to search queries, periodic performance indicators are recorded. The periodic performance indicators represent ad performance during a specific time period. Over time, the periodic performance indicators are aggregated to form historical behavior indicators. A graphical model of advertiser behavior is formulated based on the periodic performance indicators and the historical behavior indicators. The graphical model may then be used to forecast future bid values based on previous advertiser behavior.
Abstract translation: 在支持付费广告的系统中，由于广告根据与搜索查询的上下文相关性而被授予广告点，因此记录周期性绩效指标。 周期性绩效指标表示特定时间段内的广告效果。 随着时间的推移，定期绩效指标汇总成历史行为指标。 基于定期绩效指标和历史行为指标，制定了广告客户行为的图形化模型。 然后可以使用图形模型来根据先前的广告客户行为来预测未来的出价值。
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Patent Agency Ranking
公开(公告)号：US20130085867A1
公开(公告)日：2013-04-04
申请号：US13249939
申请日：2011-09-30
Applicant: Bin Gao , Tie-Yan Liu
Inventor： Bin Gao , Tie-Yan Liu
CPC classification number: G06Q30/0241 , G06Q30/0256 , G06Q30/0275
Abstract: A computing device is described herein that is configured to select a subset of keywords from a plurality of keywords based at least on measures of competition associated with the keywords and to suggest the selected subset for bidding. The plurality of keywords is relevant to at least one advertising target. The computing device calculates a measure of competition for a respective keyword based on a number of bidders for the respective keyword and on a number of available advertisement slots in search results provided responsive to queries for the respective keyword.
Abstract translation: 本文描述的计算设备被配置为至少基于与关键字相关联的竞争度量来选择来自多个关键字的关键词的子集，并且建议所选择的用于投标的子集。 多个关键字与至少一个广告目标相关。 计算设备基于针对相应关键字的投标者的数量以及响应于对各个关键字的查询而提供的搜索结果中的可用广告时隙的数量来计算相应关键字的竞争度量。
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公开(公告)号：US08374582B2
公开(公告)日：2013-02-12
申请号：US13257650
申请日：2009-12-11
Applicant: Bin Gao
Inventor： Bin Gao
IPC: H04M3/16
CPC classification number: H04W12/06 , H04L9/0844 , H04L9/0869 , H04L9/3066 , H04L63/0823 , H04L2209/80
Abstract: A method and system for accessing a cellular mobile communication network, the method includes: after a terminal and a base station complete a ranging process, the terminal carrying out a basic capability negotiation with the base station, the base station and the terminal carrying out a WAPI access authentication process; and the terminal carrying out a subsequent access flow to access the cellular mobile communication network; wherein the WAPI access authentication process includes: the terminal sending an access authentication request packet, including a certificate and a signature of the terminal, to the base station; the base station authenticating the signature of the terminal, including the certificate into a certificate authentication request packet to send to an authentication server to perform validation; the base station sending an access authentication response packet to the terminal, and carrying out a unicast session key negotiation with the terminal to obtain a unicast session key.
Abstract translation: 一种用于接入蜂窝移动通信网络的方法和系统，所述方法包括：在终端和基站完成测距过程之后，终端与基站，基站和终端进行基本能力协商， WAPI访问认证过程; 并且终端执行随后的接入流以接入蜂窝移动通信网络; 其中所述WAPI接入认证过程包括：所述终端向所述基站发送包括所述终端的证书和所述签名的接入认证请求分组; 所述基站认证所述终端的签名，所述证书包括证书认证请求报文，发送给认证服务器进行验证; 所述基站向所述终端发送接入认证响应分组，并且与所述终端进行单播会话密钥协商以获得单播会话密钥。
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公开(公告)号：US08368698B2
公开(公告)日：2013-02-05
申请号：US12236516
申请日：2008-09-24
Applicant: Bin Gao , Tie-Yan Liu , Hang Li , Yuting Liu
Inventor： Bin Gao , Tie-Yan Liu , Hang Li , Yuting Liu
CPC classification number: G06F17/30882 , G06F17/30864
Abstract: Method for creating a graph representing web browsing behavior, including receiving web browsing behavior data from one or more web browsers; adding a node on the graph for each web page listed in the web browsing behavior data; adding a first link connecting two or more nodes on the graph, wherein the first link representing a hyperlink for accessing a webpage; calculating an amount of time in which each web page is being accessed; determining a number of units of time in the calculated amount of time; adding one or more virtual nodes to the graph based on the number of units of time; and adding a second link connecting two or more virtual nodes on the graph, wherein the second link representing a virtual hyperlink for accessing a webpage.
Abstract translation: 用于创建表示网页浏览行为的图形的方法，包括从一个或多个网络浏览器接收网页浏览行为数据; 在网络浏览行为数据中列出的每个网页的图形上添加一个节点; 添加连接图上的两个或多个节点的第一链接，其中第一链接表示用于访问网页的超链接; 计算每个网页被访问的时间量; 在计算的时间量中确定时间单位的数量; 基于时间单位的数量向图中添加一个或多个虚拟节点; 以及添加连接所述图上的两个或多个虚拟节点的第二链接，其中所述第二链接表示用于访问网页的虚拟超链接。
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公开(公告)号：US20120253945A1
公开(公告)日：2012-10-04
申请号：US13078454
申请日：2011-04-01
Applicant: Bin Gao , Tie-Yan Liu , Tao Qin , Zeyong Xu , Jianhua Hu , Wei-Ying Ma
Inventor： Bin Gao , Tie-Yan Liu , Tao Qin , Zeyong Xu , Jianhua Hu , Wei-Ying Ma
CPC classification number: G06Q30/0275
Abstract: Some implementations provide techniques for estimating impression numbers. For example, a log of advertisement bidding data may be used to generate and train an impression estimation model. In some implementations, an impression estimation component may use a boost regression technique to determine a predicted impression value range based on a proposed bid received from an advertiser. For example, the predicted impression value range may be determined based on a predicted estimation error. Additionally, in some instances, the predicted impression value range may be evaluated using one or more evaluation metrics.
Abstract translation: 一些实现提供了用于估计印象数的技术。 例如，可以使用广告投标数据的日志来生成和训练印象估计模型。 在一些实现中，印象估计组件可以使用增强回归技术来基于从广告商接收到的提议的出价来确定预测的印象值范围。 例如，可以基于预测的估计误差来确定预测的印象值范围。 另外，在某些情况下，可以使用一个或多个评估度量来评估预测的印象值范围。
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公开(公告)号：US20120253927A1
公开(公告)日：2012-10-04
申请号：US13078598
申请日：2011-04-01
Applicant: Tao Qin , Tie-Yan Liu , Bin Gao , Jingyi Xu , Zeyong Xu , Wei-Ying Ma
Inventor： Tao Qin , Tie-Yan Liu , Bin Gao , Jingyi Xu , Zeyong Xu , Wei-Ying Ma
IPC: G06Q30/00
CPC classification number: G06Q30/0241
Abstract: Some implementations generate a mapping function using one or more historic performance indicators for a set of ad-keyword pairs and one or more advertisement metrics extracted from the set of ad-keyword pairs. The mapping function may be applied to map one or more advertisement metrics of a particular ad-keyword pair to determine a quality score for the particular ad-keyword pair. For example, the quality score may be used when determining whether to select an advertisement for display or may be provided as feedback to an advertiser. Additionally, in some implementations, the mapping function may be applied to determine a quality score for a new ad-keyword pair that has not yet accumulated historic information.
Abstract translation: 一些实施方式使用一组广告关键字对的一个或多个历史性能指示符和从该组广告关键字对中提取的一个或多个广告度量来生成映射函数。 可以应用映射函数来映射特定广告关键字对的一个或多个广告度量以确定特定广告关键字对的质量得分。 例如，可以在确定是否选择要显示的广告时使用质量得分，或者可以作为对广告商的反馈来提供质量得分。 另外，在一些实现中，可以应用映射函数来确定尚未累积历史信息的新的广告关键字对的质量得分。
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