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129 条记录 (耗时 0.04 秒)

    Aryl Substituted Pyridines and the Use Thereof
    1.
    发明申请
    Aryl Substituted Pyridines and the Use Thereof 有权
    芳基取代的吡啶类及其用途

    公开(公告)号：US20100048626A1

    公开(公告)日：2010-02-25

    申请号：US12546572

    申请日：2009-08-24

    申请人： Bin SHAO ,  R. Richard Goehring ,  Samuel F. Victory ,  Qun Sun

    发明人： Bin SHAO ,  R. Richard Goehring ,  Samuel F. Victory ,  Qun Sun

    IPC分类号： A61K31/4545 ,  C07D401/12 ,  C07D213/56 ,  A61K31/4418 ,  A61P25/00 ,  G01N33/00

    CPC分类号： C07D213/81 ,  C07D213/82 ,  Y10T436/145555

    摘要： This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    摘要翻译： 本发明涉及式I的芳基取代的吡啶：或其药学上可接受的盐，前药或溶剂化物，其中Ar和R 1 -R 4被置于说明书中。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

    Aryl substituted pyridines and the use thereof
    2.
    发明授权
    Aryl substituted pyridines and the use thereof 有权
    芳基取代的吡啶及其用途

    公开(公告)号：US07105549B2

    公开(公告)日：2006-09-12

    申请号：US10235673

    申请日：2002-09-06

    申请人： Bin Shao ,  R. Richard Goehring ,  Samuel F Victory ,  Qun Sun

    发明人： Bin Shao ,  R. Richard Goehring ,  Samuel F Victory ,  Qun Sun

    IPC分类号： A61K31/443 ,  A61K31/4439 ,  A61K31/451 ,  C07D213/60 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04

    CPC分类号： C07D213/81 ,  C07D213/82 ,  Y10T436/145555

    摘要： This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1–R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    摘要翻译： 本发明涉及式I的芳基取代的吡啶：或其药学上可接受的盐，前药或溶剂化物，其中Ar和R 1 -R 4定义在说明书中。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

    Systems and methods for color compensation in multi-view video
    7.
    发明授权
    Systems and methods for color compensation in multi-view video 有权
    多视图视频中色彩补偿的系统和方法

    公开(公告)号：US09264689B2

    公开(公告)日：2016-02-16

    申请号：US13412730

    申请日：2012-03-06

    申请人： Dong Li ,  Qun Sun

    发明人： Dong Li ,  Qun Sun

    IPC分类号： H04N13/02 ,  H04N5/235 ,  H04N9/09 ,  H04N13/00

    CPC分类号： H04N13/133 ,  H04N13/15 ,  H04N13/239 ,  H04N13/243 ,  H04N13/246

    摘要： An apparatus and a method for color compensation in multi-view video is provided. Video sequences corresponding to a common scene of interest are captured and processed using the master and slave channels respectively. A compensation gain is calculated based on a set of global color ratio statistics obtained from the master and slave channels. The compensation gain is applied to the slave channel. An initial master color correction matrix is combined with a master color matching matrix to obtain a final master color correction matrix. The initial slave color correction matrix is combined with a slave color matching matrix to obtain a final slave color correction matrix. The master and gain-compensated slave channels are color-compensated by applying the final master and final slave color correction matrices to the master and gain-compensated slave channels, respectively.

    摘要翻译： 提供了一种用于多视点视频中的色彩补偿的装置和方法。 使用主通道和从通道分别捕获并处理与感兴趣的共同场景相对应的视频序列。 基于从主通道和从通道获得的一组全局色彩比率计算补偿增益。 补偿增益应用于从通道。 将初始主色彩校正矩阵与主色匹配矩阵组合以获得最终主色彩校正矩阵。 将初始从色彩校正矩阵与从属色匹配矩阵组合以获得最终的从色校正矩阵。 主和增益补偿的从通道分别通过将最终的主和最后的从色彩校正矩阵应用于主和增益补偿的从通道来进行颜色补偿。

    Copolyether glycol manufacturing process
    8.
    发明授权
    Copolyether glycol manufacturing process 有权
    共聚乙二醇制造工艺

    公开(公告)号：US08609805B2

    公开(公告)日：2013-12-17

    申请号：US13247794

    申请日：2011-09-28

    申请人： Qun Sun ,  Gary L. Kiser ,  Robert D. Orlandi

    发明人： Qun Sun ,  Gary L. Kiser ,  Robert D. Orlandi

    IPC分类号： C08G65/20 ,  C08G65/30

    CPC分类号： C08G65/10 ,  C08G65/20 ,  C08G65/2609 ,  C08G65/2681 ,  C08G65/2684 ,  C08G65/2687 ,  C08G65/269 ,  C08G65/30

    摘要： The present invention provides a highly efficient process for manufacturing copolyether glycol having a mean molecular weight of from about 650 to about 5000 dalton by polymerization of tetrahydrofuran and at least one alkylene oxide in the presence of an acid catalyst and at least one compound containing reactive hydrogen atoms. More particularly, the invention relates to a process for manufacturing copolyether glycol which comprises recycle to the polymerization reaction step of at least a portion of the oligomeric cyclic ether which is co-produced with the copolyether glycol, said process exhibiting an Space Time Yield value of greater than about 0.9.

    摘要翻译： 本发明通过在酸催化剂和至少一种含有反应性氢的化合物存在下，通过四氢呋喃和至少一种烯化氧的聚合来提供平均分子量为约650至约5000道尔顿的共聚醚二醇的高效方法 原子 更具体地说，本发明涉及一种制备共聚醚二醇的方法，该方法包括将与共聚醚二醇共同生产的至少一部分低聚环醚再循环到聚合反应步骤中，所述方法表现出空时收率值 大于0.9。

    Therapeutic agents useful for treating pain
    9.
    发明授权
    Therapeutic agents useful for treating pain 有权

    公开(公告)号：US08604037B2

    公开(公告)日：2013-12-10

    申请号：US13212941

    申请日：2011-08-18

    申请人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    发明人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    IPC分类号： A61K31/501 ,  A61K31/497 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12

    CPC分类号： C07D417/12 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.