公开(公告)号：US09695444B2

公开(公告)日：2017-07-04

申请号：US14655417

申请日：2013-12-25

申请人： BioComo, Inc. ,  Mie University

发明人： Masayuki Fukumura ,  Junpei Ohtsuka ,  Tetsuya Nosaka ,  Masato Tsurudome ,  Mitsuo Kawano ,  Ken-ichiro Hara

IPC分类号： C12N15/00 ,  C12N15/86 ,  C12N7/00 ,  A61K39/00 ,  A61K39/145 ,  C12N15/09 ,  A61K39/12 ,  A61K39/155

CPC分类号： C12N15/86 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/09 ,  C12N2760/16034 ,  C12N2760/18734 ,  C12N2760/18743 ,  C12N2760/18762 ,  C12N2760/18763 ,  Y02A50/386 ,  Y02A50/394 ,  Y02A50/397

摘要： Disclosed are: a virus vector in which a gene encoding an antigenic polypeptide is integrated in human parainfluenza virus type 2 gene, wherein the antigenic polypeptide is expressed in the form of a fusion protein with a viral structural protein; and a method for producing the same. The virus vector of the present invention contains a quantitatively large amount of the antigenic peptide on the virus particle and can efficiently deliver the antigenic polypeptide to a target cell.