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1.发明申请ANTIOXIDANT DOPING OF CROSSLINKED POLYMERS TO FORM NON-ELUTING BEARING COMPONENTS 有权交联聚合物的抗氧化剂掺杂形成非涂覆轴承组件公开(公告)号：US20140148911A1
公开(公告)日：2014-05-29
申请号：US14171237
申请日：2014-02-03
CPC分类号： A61F2/34 , A61F2/32 , A61F2/38 , A61F2/389 , A61L27/16 , B23P15/003 , B29C71/02 , B29C71/04 , B29C2035/085 , B29C2071/022 , B29L2031/7532 , C08L23/06
摘要： Methods provide a non-eluting antioxidant doped UHMWPE in the form of an implant bearing component. The process includes the steps of: (a) providing a preform; (b) irradiating the preform with γ-irradiation to crosslink the UHMWPE; (c) doping the crosslinked preform by exposing it to an antioxidant composition at a temperature below the melting point of the UHMWPE; (d) removing the doped material from contact with the antioxidant composition; and then (e) annealing by heating the doped material at a temperature above 30° C. and below the melting point of the UHMWPE; followed by (f) making an implant bearing component from the doped material, wherein at least 1 mm but no more than about 15 mm of material are removed to make the component.
摘要翻译： 方法提供了植入物轴承部件形式的非洗脱抗氧化剂掺杂的UHMWPE。 该方法包括以下步骤：（a）提供预制件; （b）用γ-照射照射预型件以交联UHMWPE; （c）通过在低于UHMWPE的熔点的温度下将其暴露于抗氧化剂组合物来掺杂交联预成型体; （d）除去掺杂的材料与抗氧化剂组合物的接触; 然后（e）通过在高于30℃并低于UHMWPE的熔点的温度下加热掺杂材料进行退火; 随后（f）从掺杂材料制造植入物承载组分，其中除去至少1mm但不超过约15mm的材料以制备该组分。
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2.发明授权Antioxidant doping of crosslinked polymers to form non-eluting bearing components 有权交联聚合物的抗氧化掺杂形成非洗脱轴承组分公开(公告)号：US09421104B2
公开(公告)日：2016-08-23
申请号：US14171237
申请日：2014-02-03
IPC分类号： C08K5/15 , A61F2/34 , A61L27/16 , B29C71/02 , B29C71/04 , B23P15/00 , A61F2/32 , A61F2/38 , B29C35/08 , B29L31/00
CPC分类号： A61F2/34 , A61F2/32 , A61F2/38 , A61F2/389 , A61L27/16 , B23P15/003 , B29C71/02 , B29C71/04 , B29C2035/085 , B29C2071/022 , B29L2031/7532 , C08L23/06
摘要： Methods provide a non-eluting antioxidant doped UHMWPE in the form of an implant bearing component. The process includes the steps of: (a) providing a preform; (b) irradiating the preform with γ-irradiation to crosslink the UHMWPE; (c) doping the crosslinked preform by exposing it to an antioxidant composition at a temperature below the melting point of the UHMWPE; (d) removing the doped material from contact with the antioxidant composition; and then (e) annealing by heating the doped material at a temperature above 30° C. and below the melting point of the UHMWPE; followed by (f) making an implant bearing component from the doped material, wherein at least 1 mm but no more than about 15 mm of material are removed to make the component.
摘要翻译： 方法提供了植入物轴承部件形式的非洗脱抗氧化剂掺杂的UHMWPE。 该方法包括以下步骤：（a）提供预制件; （b）用γ-照射照射预型件以交联UHMWPE; （c）通过在低于UHMWPE的熔点的温度下将其暴露于抗氧化剂组合物来掺杂交联预成型体; （d）除去掺杂的材料与抗氧化剂组合物的接触; 然后（e）通过在高于30℃并低于UHMWPE的熔点的温度下加热掺杂材料进行退火; 随后（f）从掺杂材料制造植入物承载组分，其中除去至少1mm但不超过约15mm的材料以制备该组分。
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3.发明授权公开(公告)号：US09017590B2
公开(公告)日：2015-04-28
申请号：US13785644
申请日：2013-03-05
IPC分类号： B29C47/00 , B29C47/12 , B29C47/78 , C08J5/16 , C08J3/28 , C08F2/46 , A61F2/30 , A61L27/16 , B29C47/54 , B29C55/30 , C08F110/02 , B29C35/08 , B29K23/00 , B29K105/00
CPC分类号： A61F2/3094 , A61F2/30 , A61L27/16 , B29C47/0021 , B29C47/54 , B29C47/8805 , B29C55/30 , B29C2035/085 , B29K2023/0683 , B29K2105/25 , C08F110/02 , C08L23/06 , C08F2500/01 , C08F2500/11
摘要： Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a combination of high tensile strength and high oxidative stability. The materials are especially suitable for use as bearing components in artificial hip and other implants. Treated bulk materials are anisotropic, with enhanced strength oriented along the axial direction. The material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted crosslinked UHMWPE.
摘要翻译： 交联的高分子量聚合物如UHMWPE的固态变形处理例如通过在熔融转变以下挤出产生具有高拉伸强度和高氧化稳定性的组合的材料。 这些材料特别适用于人造髋关节和其他植入物中的轴承部件。 处理的散装材料是各向异性的，其强度沿轴向方向取向。 即使在含有五个大气压的氧气的压力容器中，即使加速老化四周后，材料也是氧化稳定的（ASTM F2003）。 由于其氧化稳定性，变形处理材料是透气包装和气体灭菌的合适的候选者，迄今为止，这已经被保留用于再熔交联的UHMWPE。
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公开(公告)号：US09586370B2
公开(公告)日：2017-03-07
申请号：US14052347
申请日：2013-10-11
IPC分类号： B29C71/02 , B29B13/02 , B29C35/02 , B29C47/00 , B29K23/00 , B29K105/00 , B29L31/06 , B29C35/08
CPC分类号： B29C71/02 , B29B13/02 , B29C35/0227 , B29C47/0004 , B29C47/0071 , B29C2035/0844 , B29C2035/085 , B29C2035/0877 , B29C2071/022 , B29K2023/0683 , B29K2105/253 , B29K2105/255 , B29K2995/0094 , B29K2995/0096 , B29L2031/06 , C08J7/08
摘要： Heat treating UHMWPE by applying pressure with radial constraint at suitable times during a heating protocol reduces or eliminates cavitation, which is otherwise observed to occur when the UHMWPE is heated to a temperature above 300° C. Heat treated UHMWPE can undergo subsequent processing involving crosslinking, deformation, doping with antioxidant, and homogenizing or annealing. Heating during these steps can be carried out even above the onset melt temperature of the UHMWPE without loss of physical properties.
摘要翻译： 通过在加热方案的适当时间通过施加径向约束的压力来热处理UHMWPE减少或消除空化，当UHMWPE被加热到高于300℃的温度时，这可以发生。热处理的UHMWPE可经历随后的加工，涉及交联， 变形，掺杂抗氧化剂，匀化或退火。 在这些步骤中的加热甚至可以在UHMWPE的起始熔融温度之上进行，而不损失物理性能。
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