公开(公告)号：US09361518B2

公开(公告)日：2016-06-07

申请号：US14336062

申请日：2014-07-21

Applicant: Bioptigen, Inc.

Inventor： Bradley A. Bower ,  Eric L. Buckland

IPC: G06K9/00 ,  A61B5/00 ,  A61B5/117 ,  G06K7/14 ,  G06T11/00

CPC classification number: G06K9/00604 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/117 ,  A61B5/1171 ,  A61B5/6821 ,  A61B5/6826 ,  G06K7/1413 ,  G06K7/1417 ,  G06K7/1447 ,  G06K9/00033 ,  G06K9/0008 ,  G06K9/00892 ,  G06T11/006

Abstract: Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.

Abstract translation: 提供使用与图像相关联的数字代码提供诊断的方法，包括收集多维图像，所述多维图像具有至少两个维度; 提取多维图像的二维子集; 将所述多维图像减少为基于所提取的二维图像对于所述多维图像是唯一的第一代码; 将与主题相关联的第一唯一代码与参考代码库进行比较，参考代码库中的每个参考代码指示一类对象; 基于比较的结果，确定与第一唯一码相关联的被摄体是否落入与参考码相关联的对象类别中的至少一个中; 以及基于与所述对象相关联的所述第一唯一代码是否落入与所述参考代码相关联的类别中的至少一个中来制定诊断决策。 本文还提供了相关系统和计算机程序产品。

公开(公告)号：US09271643B2

公开(公告)日：2016-03-01

申请号：US14551916

申请日：2014-11-24

Applicant: Bioptigen, Inc.

Inventor： Bradley A. Bower ,  Robert H. Hart ,  Pete Huening ,  Eric L. Buckland

IPC: G01B9/02 ,  A61B3/10 ,  A61B3/14

CPC classification number: A61B3/102 ,  A61B3/14 ,  G01B9/0203 ,  G01B9/02091

Abstract: Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.

Abstract translation: 提供了用于成像样本的系统。 该系统包括光学相干断层摄影（OCT）成像部分，其具有由OCT信号传送光纤和样本之间的一组光学元件限定的相关OCT路径; 图像捕获部分，具有由图像捕获装置和样本之间的不同于OCT路径的第二组光学元件定义的相关联的图像捕获路径; 以及具有由照明源和样品之间的第三组光学元件限定的相关联的照明路径的照明器部分。 OCT路径，图像捕获路径和照明器路径具有共同的至少一个光学元件，并且相应的路径由至少一个光学元件彼此不同。 OCT路径和图像捕获路径共享一个共同的中间共轭图像平面。 通过调整远离公共中间共轭平面的一个或多个共同的光学元件，通过同时进行OCT路径和图像捕获路径的焦点控制，使得焦点控制不需要在两个路径不共同的光学元件之间进行差分调整。

公开(公告)号：US20140341459A1

公开(公告)日：2014-11-20

申请号：US14336062

申请日：2014-07-21

Applicant: Bioptigen, Inc.

Inventor： Bradley A. Bower ,  Eric L. Buckland

IPC: G06K9/00 ,  G06T11/00 ,  G06K7/14

CPC classification number: G06K9/00604 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/117 ,  A61B5/1171 ,  A61B5/6821 ,  A61B5/6826 ,  G06K7/1413 ,  G06K7/1417 ,  G06K7/1447 ,  G06K9/00033 ,  G06K9/0008 ,  G06K9/00892 ,  G06T11/006

Abstract: Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.

Abstract translation: 提供使用与图像相关联的数字代码提供诊断的方法，包括收集多维图像，所述多维图像具有至少两个维度; 提取多维图像的二维子集; 将所述多维图像减少为基于所提取的二维图像对于所述多维图像是唯一的第一代码; 将与主题相关联的第一唯一代码与参考代码库进行比较，参考代码库中的每个参考代码指示一类对象; 基于比较的结果，确定与第一唯一码相关联的被摄体是否落入与参考码相关联的对象类别中的至少一个中; 以及基于与所述对象相关联的所述第一唯一代码是否落入与所述参考代码相关联的类别中的至少一个中来制定诊断决策。 本文还提供了相关系统和计算机程序产品。

公开(公告)号：US20130329188A1

公开(公告)日：2013-12-12

申请号：US13966452

申请日：2013-08-14

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower

IPC: A61B3/10

CPC classification number: A61B3/102 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

Abstract translation: 提供了用于扩展深度频域光学相干断层摄影的系统，其包括被配置为以基本相等的频率间隔对频谱元素进行采样的检测系统，其中与采样的频谱元素相关联的频谱宽度不大于频率间隔的一半。 本文还提供了相关方法。

公开(公告)号：US20170164826A1

公开(公告)日：2017-06-15

申请号：US15442749

申请日：2017-02-27

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Robert H. Hart ,  Pete Huening

IPC: A61B3/10 ,  G01B9/02 ,  A61B3/14

CPC classification number: A61B3/102 ,  A61B3/14 ,  G01B9/0203 ,  G01B9/02091

Abstract: Systems for imaging a sample are provided. The system includes an OCT imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The illumination path includes a multi-wavelength source of optical radiation.

公开(公告)号：US20140300902A1

公开(公告)日：2014-10-09

申请号：US14309021

申请日：2014-06-19

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower

IPC: G01B9/02 ,  A61B3/10

CPC classification number: A61B3/102 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: Systems for extended depth frequency domain optical coherence tomography are provided including including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

Abstract translation: 提供了用于扩展深度频域光学相干断层摄影的系统，包括配置成以基本相等的频率间隔采样频谱元素的检测系统，其中与采样的频谱元素相关联的频谱宽度不大于频率间隔的一半。 本文还提供了相关方法。

公开(公告)号：US08644572B2

公开(公告)日：2014-02-04

申请号：US13779956

申请日：2013-02-28

Applicant: Bioptigen, Inc.

Inventor： Joseph A. Izatt ,  Eric L. Buckland ,  Bennett R. Groshong ,  Bradley A. Bower

IPC: G06K9/20

CPC classification number: G01B9/02091 ,  A61B3/102 ,  A61B3/117 ,  A61B5/0066 ,  A61B5/7207 ,  A61B5/7257 ,  G01N21/4795 ,  G01P3/36 ,  G06T11/003

Abstract: Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.

Abstract translation: 用于管理频域光学相干断层扫描（FDOCT）图像分辨率的方法，系统和计算机程序产品。 用于获取被摄体图像的光谱被校准，并且设置默认色散校正参数。 还设置与被摄体的图像的区域相关联的默认色散管理参数。 在设置默认色散校正参数和默认色散管理参数后，获取被摄体的图像。 将所获取的图像的质量与所获取的图像的质量度量进行比较。 如果所获取的图像的质量不满足或超过所获取的图像的质量度量，则调整色散校正参数。 所获取的图像基于经调整的色散校正参数进行再处理。 重复比较，调整和重新处理的步骤，直到所获取的图像满足或超过所获取的图像的质量度量。

公开(公告)号：US08529062B2

公开(公告)日：2013-09-10

申请号：US13686214

申请日：2012-11-27

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower

IPC: A61B3/14 ,  A61B3/00 ,  G01B11/02

CPC classification number: A61B3/102 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

公开(公告)号：US20130202176A1

公开(公告)日：2013-08-08

申请号：US13779956

申请日：2013-02-28

Applicant: Bioptigen, Inc.

Inventor： Joseph A. Izatt ,  Eric L. Buckland ,  Bennett R. Groshong ,  Bradley A. Bower

IPC: G06T11/00

CPC classification number: G01B9/02091 ,  A61B3/102 ,  A61B3/117 ,  A61B5/0066 ,  A61B5/7207 ,  A61B5/7257 ,  G01N21/4795 ,  G01P3/36 ,  G06T11/003

Abstract: Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.

Abstract translation: 用于管理频域光学相干断层扫描（FDOCT）图像分辨率的方法，系统和计算机程序产品。 用于获取被摄体图像的光谱被校准，并且设置默认色散校正参数。 还设置与被摄体的图像的区域相关联的默认色散管理参数。 在设置默认色散校正参数和默认色散管理参数后，获取被摄体的图像。 将所获取的图像的质量与所获取的图像的质量度量进行比较。 如果所获取的图像的质量不满足或超过所获取的图像的质量度量，则调整色散校正参数。 所获取的图像基于经调整的色散校正参数进行再处理。 重复比较，调整和重新处理的步骤，直到所获取的图像满足或超过所获取的图像的质量度量。

公开(公告)号：US10307056B2

公开(公告)日：2019-06-04

申请号：US14561684

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Ryan Gessner

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12

Abstract: Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.