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公开(公告)号:US20070059803A1
公开(公告)日:2007-03-15
申请号:US11503324
申请日:2006-08-10
申请人: Birgit Oppmann , Rene de Waal Malefyt , Donna Rennick , Robert Kastelein , Maria Wiekowski , Sergio Lira , Satwant Narula
发明人: Birgit Oppmann , Rene de Waal Malefyt , Donna Rennick , Robert Kastelein , Maria Wiekowski , Sergio Lira , Satwant Narula
IPC分类号: A61K38/17 , A61K31/573 , C07K16/24 , C07K14/54 , C07K14/715 , C07H21/04 , C12P21/04
CPC分类号: C07K16/244 , A01K2217/05 , A61K38/00 , C07K14/54 , C07K14/5434 , C07K2317/32 , C07K2319/00 , C07K2319/02 , Y10S530/827
摘要: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码哺乳动物细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US08691953B2
公开(公告)日:2014-04-08
申请号:US13330902
申请日:2011-12-20
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K16/00
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20080226654A1
公开(公告)日:2008-09-18
申请号:US11437391
申请日:2006-07-13
申请人: J. Fernando Bazan , Amy M. Beebe , Rene de Waal Malefyt , Daniel M. Gorman , Peter Kirk , Hirokazu Kurata , Donna Rennick
发明人: J. Fernando Bazan , Amy M. Beebe , Rene de Waal Malefyt , Daniel M. Gorman , Peter Kirk , Hirokazu Kurata , Donna Rennick
IPC分类号: A61K39/395 , C12N5/00 , A61P19/08
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , C12N2799/022
摘要: Provided are methods of treatment for bone disorders related to bone deposition and resorption dysfunction. These bone disorders may be the result of inflammation, cancers, etc. Provided are methods of using agonists or antagonists of a cytokine molecule.
摘要翻译: 提供了与骨沉积和吸收功能障碍相关的骨骼疾病的治疗方法。 这些骨骼疾病可能是炎症,癌症等的结果。提供使用细胞因子分子的激动剂或拮抗剂的方法。
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公开(公告)号:US20090191569A1
公开(公告)日:2009-07-30
申请号:US12414267
申请日:2009-03-30
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C12Q1/68 , G01N33/53 , C12P21/06 , C12N5/00 , C12N5/02 , C12N15/63 , C07K7/08 , C07K16/00 , C07H21/02
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US07579440B2
公开(公告)日:2009-08-25
申请号:US10777790
申请日:2004-02-11
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K14/00
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
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公开(公告)号:US07148330B2
公开(公告)日:2006-12-12
申请号:US10000776
申请日:2001-11-30
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K16/24
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20120115164A1
公开(公告)日:2012-05-10
申请号:US13330902
申请日:2011-12-20
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US08080392B2
公开(公告)日:2011-12-20
申请号:US13025002
申请日:2011-02-10
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C12N15/09
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US07906622B2
公开(公告)日:2011-03-15
申请号:US12414267
申请日:2009-03-30
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K14/52
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20060140950A1
公开(公告)日:2006-06-29
申请号:US11359269
申请日:2006-02-21
申请人: Daniel Cua , Yi Chen , Robert Kastelein , Claire Langrish , Donna Rennick , Jonathon Sedgwick
发明人: Daniel Cua , Yi Chen , Robert Kastelein , Claire Langrish , Donna Rennick , Jonathon Sedgwick
IPC分类号: A61K48/00 , A61K38/17 , A61K39/395
摘要: Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
摘要翻译: 提供了治疗中枢神经系统和胃肠道的炎性和自身免疫性疾病的方法。 还提供诊断方法。
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