公开(公告)号：US20140005554A1

公开(公告)日：2014-01-02

申请号：US13719729

申请日：2012-12-19

Applicant: Biswajit Das ,  Frank van Breukelen

Inventor： Biswajit Das ,  Frank van Breukelen

IPC: A61B5/026

CPC classification number: A61B5/0261 ,  A61B5/01

Abstract: Systems enable a method of determining the rate of flow of a bodily fluid through a vessel in a live patient by: positioning at least two separate passive infrared sensors at two points along a length of the vessel; sensing local temperature changes at the two points along the vessel to generate signals of the local temperature changes from each passive infrared sensor; a processor receiving the signals and quantifying the local temperature changes at the two points; and the processor executing code to determine blood flow rate in the vessel from the local temperature changes quantified by the processor at the two points.

Abstract translation: 系统使得能够通过以下方式确定身体流体通过活体患者血管的流速：在沿血管长度的两个点处定位至少两个单独的被动红外传感器; 检测沿船舶两点的局部温度变化，以产生每个被动红外传感器的局部温度变化信号; 处理器接收信号并量化两点处的局部温度变化; 并且所述处理器执行代码以从由所述两点处理器量化的局部温度变化来确定所述容器中的血液流量。

公开(公告)号：US20140187542A1

公开(公告)日：2014-07-03

申请号：US13983540

申请日：2012-02-06

Applicant: Hiroaki Inagaki ,  Tetsunori Fujisawa ,  Masao Itoh ,  Aki Yokomizo ,  Toshifumi Tsuda ,  Saito Higuchi ,  Biswajit Das ,  Rita Katoch ,  Dilip J. Upadhyay

Inventor： Hiroaki Inagaki ,  Tetsunori Fujisawa ,  Masao Itoh ,  Aki Yokomizo ,  Toshifumi Tsuda ,  Saito Higuchi ,  Biswajit Das ,  Rita Katoch ,  Dilip J. Upadhyay

IPC: C07D498/04 ,  C07D487/04 ,  C07D413/14

CPC classification number: C07D487/04 ,  A61K31/5383 ,  C07D241/44 ,  C07D265/36 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  Y02A50/475

Abstract: A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom Ar1 represents a bicyclic heterocyclic group represented by the following formula: and Ar2 represents a bicyclic heterocyclic group represented by the following formulae:

Abstract translation: 由下式（I）表示的化合物或其盐：其中R表示氢原子，羟基或卤素原子Ar1表示由下式表示的双环杂环基：Ar2表示双环杂环基， 通过以下公式：

公开(公告)号：US20090215764A1

公开(公告)日：2009-08-27

申请号：US11913380

申请日：2006-05-03

Applicant: Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

Inventor： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

IPC: A61K31/535 ,  C07D217/00 ,  A61K31/47 ,  C07D211/00 ,  A61K31/445 ,  C07D265/30 ,  C07D401/02 ,  A61K31/4545

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract translation: 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮生长素，亨氏嗜血菌属，组织胞浆菌属，微孢子虫属，拟青霉菌属， ，肺孢子虫（Pneumocystis），毛癣菌（Trichophyton）或三孢子虫（Trichosporium）。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：US20090170790A1

公开(公告)日：2009-07-02

申请号：US11577900

申请日：2005-10-25

Applicant: Biswajit Das ,  Mohammad Salman ,  Santosh Haribhau Kurhade ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Rita Katoch ,  Anish Bandyopadhyay ,  Ashok Rattan

Inventor： Biswajit Das ,  Mohammad Salman ,  Santosh Haribhau Kurhade ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Rita Katoch ,  Anish Bandyopadhyay ,  Ashok Rattan

IPC: A61K31/7028 ,  C07H17/08 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as anti-bacterial agents. Compounds disclosed herein can be used for the treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨卡氏菌，衣原体属， 支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，其合成中使用的中间体，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20090018174A1

公开(公告)日：2009-01-15

申请号：US12093041

申请日：2006-11-08

Applicant: Pradip Kumar Bhatnagar ,  Anjan Chakrabarti ,  Biswajit Das ,  Malini Bajpai ,  Abhijit Ray

Inventor： Pradip Kumar Bhatnagar ,  Anjan Chakrabarti ,  Biswajit Das ,  Malini Bajpai ,  Abhijit Ray

IPC: A61K31/365 ,  A61K31/424

CPC classification number: A61K31/7048

Abstract: Provided herein are macrolide derivatives that can be useful in treating or preventing inflammatory diseases. Also provided are pharmaceutical compositions comprising one or more macrolide derivatives optionally together with one or more pharmaceutically acceptable carriers, excipients, diluents or mixtures thereof, as well as methods for treating or preventing inflammatory diseases.

Abstract translation: 本文提供可用于治疗或预防炎性疾病的大环内​​酯衍生物。 还提供药物组合物，其包含一种或多种大环内酯衍生物，任选与一种或多种药学上可接受的载体，赋形剂，稀释剂或其混合物，以及治疗或预防炎性疾病的方法。

公开(公告)号：US20080318878A1

公开(公告)日：2008-12-25

申请号：US11576033

申请日：2005-09-27

Applicant: Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Ashok Rattan

Inventor： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Ashok Rattan

IPC: A61K31/7048 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属（Chlamydia spp。 ，支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了制备本文公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20080287376A1

公开(公告)日：2008-11-20

申请号：US11572619

申请日：2005-07-28

Applicant: Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

Inventor： Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

IPC: A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp. Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebaclerium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌。 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US08084101B2

公开(公告)日：2011-12-27

申请号：US11888476

申请日：2007-08-01

Applicant: Biswajit Das

Inventor： Biswajit Das

IPC: B05D1/40 ,  B05D3/14

CPC classification number: B82B3/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/25

Abstract: Methods, apparatus and systems form structures from nanoparticles by: providing a source of nanoparticles, the particles being capable of being moved by application of a field, such as an electrical field, magnetic field and even electromagnetic radiation or fields such as light, UV, IR, radiowaves, radiation and the like; depositing the nanoparticles to a surface in a first distribution of the nanoparticles; applying a field to the nanoparticles on the surface that applies a force to the particles; and rearranging the nanoparticles on the surface by the force from the field to form a second distribution of nanoparticles on the surface. The second distribution of nanoparticles is more ordered or more patterned than the first distribution of nanoparticles as a result of the rearranging.

Abstract translation: 方法，装置和系统通过以下方式形成纳米颗粒的结构：提供纳米颗粒源，所述颗粒能够通过施加场，例如电场，磁场，甚至电磁辐射或诸如光，UV， 红外线，无线电波，辐射等; 将纳米颗粒沉积在纳米颗粒的第一分布中的表面上; 将场施加到对颗粒施加力的表面上的纳米颗粒; 并且通过来自场的力将表面上的纳米颗粒重新排列以在表面上形成纳米颗粒的第二分布。 由于重新排列，纳米颗粒的第二分布比纳米颗粒的第一分布更有序或更加图案化。

公开(公告)号：US08076370B2

公开(公告)日：2011-12-13

申请号：US11913380

申请日：2006-05-03

Applicant: Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

Inventor： Biswajit Das ,  Jasbir Singh Arora ,  Shahadat Ahmed ,  Anish Bandyopadhyay ,  Rita Katoch ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Soma Ghosh ,  Abhijit Datta Khoje ,  Arti Gujrati ,  Dilip J. Upadhyay

IPC: A61K31/27 ,  A61K31/18 ,  A61K31/155 ,  A61K31/44 ,  A61K31/501 ,  C07D213/72 ,  C07C333/00 ,  C07C303/00 ,  C07C277/00

CPC classification number: C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D231/20 ,  C07D239/42 ,  C07D249/12 ,  C07D277/36 ,  C07D295/096 ,  C07D307/68 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D513/04

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract translation: 本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉， 大肠杆菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母​​属，椰子球菌属，隐球菌属，表皮生长素，亨氏嗜血菌属，组织胞浆菌属，微孢子虫属，拟青霉菌属， ，肺孢子虫（Pneumocystis），毛癣菌（Trichophyton）或三孢子虫（Trichosporium）。 还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

公开(公告)号：US20100286211A1

公开(公告)日：2010-11-11

申请号：US11576635

申请日：2005-10-06

Applicant: Biswajit Das ,  Shahadal Ahmed ,  Ajay Singh Yadav ,  Soma Ghosh ,  Arti Gujrati ,  Pankaj Sharma ,  Ashok Rattan

Inventor： Biswajit Das ,  Shahadal Ahmed ,  Ajay Singh Yadav ,  Soma Ghosh ,  Arti Gujrati ,  Pankaj Sharma ,  Ashok Rattan

IPC: A61K31/4439 ,  A61K31/433 ,  A61K31/421 ,  C07D417/14 ,  A61K31/4245 ,  C07D263/20 ,  C07D413/14 ,  A61K31/422 ,  A61P31/04

CPC classification number: C07D263/22 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

Abstract translation: 本发明涉及某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌，例如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧生物，例如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，例如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。