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公开(公告)号：US20030130309A1
公开(公告)日：2003-07-10
申请号：US10187942
申请日：2002-07-01
发明人： Neil Moss , John Robinson Regan
IPC分类号： A61K031/47 , A61K031/425 , A61K031/421 , A61K031/415 , A61K031/381 , A61K031/4184 , A61K031/17
CPC分类号： A61K31/5377 , A61K31/216 , A61K31/415 , A61K31/435
摘要： Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. 1
摘要翻译： 本文公开了使用式（I）的新型芳族杂环化合物治疗某些细胞因子介导的疾病或病症的方法，其中本文描述了Ar1，Ar2，L，Q和X。
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公开(公告)号：US20030060455A1
公开(公告)日：2003-03-27
申请号：US10237306
申请日：2002-09-09
发明人： Neil Moss , John Robinson Regan
IPC分类号： A61K031/55 , A61K031/553 , A61K031/554 , A61K031/54 , A61K031/537 , A61K031/495 , A61K031/445 , A61K031/325
CPC分类号： A61K31/547 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/537 , A61K31/5377 , Y02A50/401
摘要： Disclosed are methods of treating acute and chronic inflammation in the lung caused by inhalation of smoke, endometriosis, Behcet's disease, uveitis, ankylosing spondylitis, pancreatitis, cancer, Lyme disease, sepsis, chronic obstructive pulmonary disease, traumatic arthritis, congestive heart failure and restenosis following percutaneous transluminal coronary angioplasty, known to be cytokine mediated, using aromatic heterocyclic compounds described in WO 00/55139.
摘要翻译： 公开了治疗由吸入烟雾，子宫内膜异位症，白塞病，葡萄膜炎，强直性脊柱炎，胰腺炎，癌症，莱姆病，败血症，慢性阻塞性肺病，创伤性关节炎，充血性心力衰竭和再狭窄引起的肺部急性和慢性炎症的方法 已知使用WO 00/55139中描述的芳族杂环化合物的经皮腔内冠状动脉血管成形术（以下称为细胞因子介导）。
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公开(公告)号：US20030225053A1
公开(公告)日：2003-12-04
申请号：US10410688
申请日：2003-04-10
发明人： Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Kevin Chungeng Qian , Gregory Paul Roth , Christopher Ronald Sarko , Alan David Swinamer , Zhaoming Xiong
IPC分类号： A61K031/541 , A61K031/5377 , A61K031/52 , A61K031/496 , A61K031/519 , A61K031/517 , A61K031/454 , A61K031/4439 , A61K031/427 , A61K031/4184 , C07D417/02 , C07D413/02 , C07D43/02
CPC分类号： C07D401/12 , C07C311/08 , C07D209/42 , C07D307/85 , C07D333/70 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Disclosed are amide compounds of formula(I): 1 wherein Ar1, Q, Y and R3-R6 of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的酰胺化合物：其中式（I）的Ar 1，Q，Y和R 3 -R 6在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20030008868A1
公开(公告)日：2003-01-09
申请号：US10143322
申请日：2002-05-10
发明人： Pier Francesco Cirillo , Daniel R. Goldberg , Abdelhakim Hammach , Neil Moss , John Robinson Regan
IPC分类号： A61K031/5377 , A61K031/53 , A61K031/513 , A61K031/366
CPC分类号： C07D403/12 , A61K31/505 , A61K31/506 , C07D213/38 , C07D213/63 , C07D231/40 , C07D239/34 , C07D239/46 , C07D239/47 , C07D251/16 , C07D251/22 , C07D309/12 , C07D309/38 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
摘要翻译： 公开了用于治疗涉及炎症的疾病或病理状况的药物组合物中的化合物，例如慢性炎性疾病。 还公开了制备这些化合物的方法。
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公开(公告)号：US20040186114A1
公开(公告)日：2004-09-23
申请号：US10789354
申请日：2004-02-27
发明人： Pier Francesco Cirillo , Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Matthew Russell Netherton , Kevin Chungeng Qian , Mark Stephen Ralph , Lifen Wu , Zhaoming Xiong
IPC分类号： A61K031/513 , A61K031/506 , C07D413/02 , C07D417/02 , A61K031/4439
CPC分类号： C07D401/12 , C07D403/12
摘要： Disclosed are compounds of formula (I) 1 Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，Y，Q，W，R 3，R 4，R 5，R 6和R y在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 该化合物也可用于治疗与肿瘤学和抗凝血剂或纤维蛋白溶解疗法有关的疾病或病症。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20040152725A1
公开(公告)日：2004-08-05
申请号：US10761913
申请日：2004-01-20
发明人： Neil Moss , John Robinson Regan
IPC分类号： A61K031/4709 , A61K031/427 , A61K031/422 , A61K031/4184 , A61K031/4178 , A61K031/416
CPC分类号： A61K31/5377 , A61K31/216 , A61K31/415 , A61K31/435
摘要： Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. 1
摘要翻译： 本文公开了使用式（I）的新型芳族杂环化合物治疗某些细胞因子介导的疾病或病症的方法，其中本文描述了Ar1，Ar2，L，Q和X。
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公开(公告)号：US20040077647A1
公开(公告)日：2004-04-22
申请号：US10632998
申请日：2003-08-01
发明人： Pier Francesco Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul S. Riska , Christopher Pargellis
IPC分类号： A61K031/5377 , A61K031/513 , A61K031/496 , A61K031/44 , C07D413/02 , C07D43/02
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D405/12
摘要： Disclosed are compounds of formula (I): 1 wherein R1, R2, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20030207902A1
公开(公告)日：2003-11-06
申请号：US10271222
申请日：2002-10-15
发明人： Roger John Snow , Donghong A. Gao , Daniel R. Goldberg , Abdelhakim Hammach , Daniel Kuzmich , Tina Marie Morwick , Neil Moss , Anthony S. Prokopowicz III , Robert D. Selliah , Hidenori Takahashi
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , A61K31/517
摘要： Disclosed are novel compounds of formula (I): 1 wherein Ar1, X, Y, P, Q and Het are defined herein, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are pharmaceutical compositions comprising these compounds, processes for preparing these compounds and novel intermediate compounds useful in these processes.
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公开(公告)号：US20030166929A1
公开(公告)日：2003-09-04
申请号：US10292026
申请日：2002-11-12
发明人： Roger John Snow , Mario G. Cardozo , Daniel R. Goldberg , Abdelhakim Hammach , Tina M. Morwick , Neil Moss , Usha R. Patel , Anthony S. Prokopowicz III , Hindenori Takahashi , Matt Aaron Tschantz , Xiao-Jun Wang
IPC分类号： C07D491/02 , C07D498/02 , C07D471/02
CPC分类号： C07D471/04 , C07D217/24 , C07D235/30 , C07D513/04
摘要： Disclosed are novel compounds of formula (I): 1 wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of the formula (I).
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