摘要:
The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.
摘要:
The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1 (7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.
摘要:
FIG. 1 is a top perspective view of a set of shredder, showing my new design. FIG. 2 is bottom perspective view thereof. FIG. 3 is a front view thereof. FIG. 4 is a rear view thereof. FIG. 5 is a left side view thereof. FIG. 6 is a right side view thereof. FIG. 7 is a top view thereof. FIG. 8 is a bottom view thereof; and, FIG. 9 is a top perspective view thereof, shown in assembled condition. The broken lines shown in the drawings represent portions of the set of shredder that form no part of the claimed design.
摘要:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要:
Described herein are substituted bicyclic amines. In particular, described herein are substituted bicyclic amines that are effective as antagonists of SSTR5 and useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, metabolic syndrome, depression, and anxiety.
摘要:
Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要:
The keyword extraction technique described herein extracts keywords from Uniform Resource Locators (URLs) in web logs. The technique leverages the content and the structure of URLs to extract relevant keywords. First, a URL is divided into multiple components based on its structure. A set of keywords are extracted from each component of the URL independently with the help of a controlled vocabulary. Then a second set of keywords are generated by forming combinations of terms from different segments of the URL. Only those combinations which are present in the controlled vocabulary are retained as keywords. Finally, the keywords are scored with a function which took into account of a wide set of features.
摘要:
Systems and methods for finding related terms based on three different sources are disclosed. Generally, a first plurality of distances is determined based on one or more received terms and a first plurality of terms derived from an algorithmic search list. A second plurality of distances is determined based on the one or more received terms and a second plurality of terms derived from a sponsored search list. A third plurality of distances is determined based on the one or more received terms and a third plurality of terms derived from search logs. The first, second, and third pluralities of distances are combined to derive a fourth plurality of distances. Finally, a plurality of related terms related to the one or more received terms is generated based on the fourth plurality of distances.
摘要:
Disclosed are methods and apparatus for analyzing campaigns in order to identify similar campaigns are disclosed. In one embodiment, an ad campaign associated with an advertiser is identified. Ad campaign information associated with ad campaigns previously booked by an online publisher is analyzed to identify one or more of the ad campaigns previously booked by the online publisher that are similar to the ad campaign. The ad campaign information for each of the ad campaigns identifies one or more products of the online publisher. The ad campaign information may be processed by applying natural language processing (NLP) to at least a portion of the ad campaign information associated with the ad campaigns previously booked by the online publisher. At least one of the products of the online publisher to recommend to the advertiser are ascertained from the ad campaign information for the one or more ad campaigns previously booked by the online publisher that are similar to the ad campaign.
摘要:
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.