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公开(公告)号:US20170044183A1
公开(公告)日:2017-02-16
申请号:US15305421
申请日:2015-04-21
申请人: Yeon-Hee Lim , Zhuyan Guo , Amjad Ali , Scott D. Edmondson , Weiguo Liu , Giocanda V. Gallo-Etienne , Heping Wu , Ying-Duo Gao , Andrew W. Stamford , Younong Yu , Nancy J. Kevin , Rajan Anand , Deyou Sha , Santhosh F. Neelamkavil , Zahid Hussain , Puneet Kumar , Remond Moningka , Joseph L. Duffy , Jiayi Xu , Yu Jiang , Anjan Chakrabarti , Hiroki Sone
发明人: Yeon-Hee Lim , Zhuyan Guo , Amjad Ali , Scott D. Edmondson , Weiguo Liu , Giocanda V. Gallo-Etienne , Heping Wu , Ying-Duo Gao , Andrew W. Stamford , Younong Yu , Nancy J. Kevin , Rajan Anand , Deyou Sha , Santhosh F. Neelamkavil , Zahid Hussain , Puneet Kumar , Remond Moningka , Joseph L. Duffy , Jiayi Xu , Yu Jiang , Anjan Chakrabarti , Hiroki Sone
IPC分类号: C07D498/20 , C07F9/6561 , C07D487/10 , C07D498/10 , C07D471/10
CPC分类号: C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译: 本发明提供式(I)的化合物和包含一种或多种所述化合物的药物组合物,以及使用所述化合物治疗或预防血栓形成,栓塞,高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号:US20160347757A1
公开(公告)日:2016-12-01
申请号:US15116659
申请日:2015-02-06
申请人: Santhosh F. NEELAMKAVIL , Scott D. EDMONDSON , Zhuyan GUO , Alan W. HRUZA , Zahid HUSSAIN , Charles A. LESBURG , Remond MONINGKA , Anthony K. OGAWA , Rudrajit MAL , MERCK SHARP & DOHME CORP
发明人: Santhosh F. Neelamkavil , Scott D. Edmondson , Zhuyan Guo , Alan W. Hruza , Zahid Hussain , Charles A. Lesburg , Remond Moningka , Anthony K. Ogawa , Rudrajit Mal
IPC分类号: C07D487/08 , C07D471/08
CPC分类号: C07D487/08 , C07D471/08
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译: 本发明提供式(I)的化合物和包含一种或多种所述化合物的药物组合物,以及使用所述化合物治疗或预防血栓形成,栓塞,高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号:US09944643B2
公开(公告)日:2018-04-17
申请号:US15116547
申请日:2015-02-06
申请人: MERCK SHARP & DOHME CORP. , Santhosh F. Neelamkavil , Scott D. Edmondson , Alan W. Hruza , Zahid Hussain , Charles Lesburg , Remond Moningka
发明人: Santhosh F. Neelamkavil , Scott D. Edmondson , Alan W. Hruza , Zahid Hussain , Charles Lesburg , Remond Moningka
IPC分类号: C07D471/08 , C07D487/08
CPC分类号: C07D471/08 , C07D487/08
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20130131042A1
公开(公告)日:2013-05-23
申请号:US13810946
申请日:2011-08-12
申请人: Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
发明人: Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
IPC分类号: C07D498/10 , C07D519/00
CPC分类号: C07D498/10 , C07D519/00
摘要: Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要翻译: 结构式(I)的取代的螺环胺是生长抑素亚型受体5(SSTR5)的选择性拮抗剂,可用于治疗,控制或预防对SSTR5的拮抗作用反应的病症,例如2型糖尿病,胰岛素抵抗,脂质障碍 ,肥胖症,动脉粥样硬化,代谢综合征,抑郁症和焦虑症。
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公开(公告)号:US08742110B2
公开(公告)日:2014-06-03
申请号:US13810946
申请日:2011-08-12
申请人: Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
发明人: Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
IPC分类号: C07D215/00 , C07D229/00 , A61K31/44 , A61K31/397
CPC分类号: C07D498/10 , C07D519/00
摘要: Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要翻译: 结构式(I)的取代的螺环胺是生长抑素亚型受体5(SSTR5)的选择性拮抗剂,可用于治疗,控制或预防对SSTR5的拮抗作用有响应的病症,例如2型糖尿病,胰岛素抵抗,脂质障碍 ,肥胖症,动脉粥样硬化,代谢综合征,抑郁症和焦虑症。
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公开(公告)号:US20160376272A1
公开(公告)日:2016-12-29
申请号:US15116547
申请日:2015-02-06
申请人: Santhosh F. NEELAKAVIL , Scott D. EDMONDSON , Alan W. HRUZA , Zahid HUSSAIN , Charles LESBURG , Remond MONINGKA , Merck Sharp & Dohme Corp.
发明人: Santhosh F. Neelamkavil , Scott D. Edmondson , Alan W. Hruza , Zahid Hussain , Charles Lesburg , Remond Moningka
IPC分类号: C07D471/08 , C07D487/08
CPC分类号: C07D471/08 , C07D487/08
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20130040978A1
公开(公告)日:2013-02-14
申请号:US13641767
申请日:2011-05-13
申请人: Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Paul E. Finke , Yi Zang , Michael A. Plotkin , F. Anthony Romero , Remond Moningka , Zahid Hussain
发明人: Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Paul E. Finke , Yi Zang , Michael A. Plotkin , F. Anthony Romero , Remond Moningka , Zahid Hussain
IPC分类号: C07D498/10 , C07D519/00 , A61P25/22 , A61P3/04 , A61P3/00 , A61P25/24 , A61K31/438 , A61P3/10
CPC分类号: C07D498/10 , C07D519/00
摘要: Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要翻译: 结构式(I)的取代的螺环胺是生长抑素亚型受体5(SSTR5)的选择性拮抗剂,可用于治疗,控制或预防对SSTR5的拮抗作用有响应的病症,例如2型糖尿病,胰岛素抵抗,脂质障碍 ,肥胖症,动脉粥样硬化,代谢综合征,抑郁症和焦虑症。
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公开(公告)号:US20160229839A1
公开(公告)日:2016-08-11
申请号:US15023833
申请日:2014-09-23
申请人: Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
发明人: Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
IPC分类号: C07D401/14 , A01N1/02 , C07D401/06 , C07D401/10 , C07D211/60
CPC分类号: C07D401/14 , A01N1/0226 , C07D211/60 , C07D401/06 , C07D401/10 , C12N9/6443 , C12Y304/21027
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译: 本发明提供式(I)的化合物和包含一种或多种所述化合物的药物组合物,以及使用所述化合物治疗或预防血栓形成,栓塞,高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号:US08498333B2
公开(公告)日:2013-07-30
申请号:US11763729
申请日:2007-06-15
申请人: Zahid Hussain
发明人: Zahid Hussain
CPC分类号: H04N19/86 , H04N19/12 , H04N19/122 , H04N19/136 , H04N19/176 , H04N19/423 , H04N19/61 , H04N19/82
摘要: Included are embodiments for processing video data. At least one embodiment includes receive logic configured to receive the video data chosen from a plurality of formats and filter logic configured to filter the video data according to the instruction. Similarly, some embodiments include transform logic configured to transform the video data according to the instruction, where the instruction contains a mode indication in which the filter logic and the transform logic execute based on the format of the video data.
摘要翻译: 包括用于处理视频数据的实施例。 至少一个实施例包括被配置为接收从多个格式中选择的视频数据的接收逻辑和被配置为根据指令过滤视频数据的滤波器逻辑。 类似地,一些实施例包括被配置为根据指令变换视频数据的变换逻辑,其中指令包含基于视频数据的格式来执行滤波器逻辑和变换逻辑的模式指示。
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公开(公告)号:US20130155095A1
公开(公告)日:2013-06-20
申请号:US13325964
申请日:2011-12-14
申请人: Zahid Hussain
发明人: Zahid Hussain
CPC分类号: H04N21/42207 , H04N21/42209 , H04N21/4222 , H04N21/42224 , H04N21/4312 , H04N21/4431
摘要: A content player transmits a screen image to a display. The screen image includes an active region, which may be a portion that may be manipulated. The player determines active region information for the active region and transmits such to a portable device. The portable device receives the active region information as well as information regarding any inactive regions, which may be portions that may not be manipulated. The portable device utilizes the information to present a simulated version of the screen image on a touch screen. The portable device may then receive manipulation information via the touch screen and transmit such to the player. In response, the player may generate and present an updated version of the screen image, determine updated information, and transmit such to the portable device. The portable device may utilize the updated information to present a simulated updated version of the screen image.
摘要翻译: 内容播放器将屏幕图像发送到显示器。 屏幕图像包括有效区域,其可以是可以被操纵的部分。 播放器确定活动区域的有效区域信息并将其发送到便携式设备。 便携式设备接收有源区域信息以及关于任何不活动区域的信息,其可以是可能不被操纵的部分。 便携式设备利用该信息在触摸屏上呈现屏幕图像的模拟版本。 便携式设备然后可以经由触摸屏接收操作信息并将其发送给播放器。 作为响应,播放器可以生成并呈现屏幕图像的更新版本,确定更新的信息,并将其发送到便携式设备。 便携式设备可以利用更新的信息来呈现屏幕图像的模拟更新版本。
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