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公开(公告)号：US20240307588A1
公开(公告)日：2024-09-19
申请号：US18675481
申请日：2024-05-28
发明人： Joseph T. Delaney, JR. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
CPC分类号： A61L27/16 , A61L27/18 , A61L27/3839 , A61L27/50
摘要： Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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公开(公告)号：US12016969B2
公开(公告)日：2024-06-25
申请号：US17165485
申请日：2021-02-02
发明人： Joseph T. Delaney, Jr. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
CPC分类号： A61L27/16 , A61L27/18 , A61L27/3839 , A61L27/50
摘要： Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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公开(公告)号：US20220313603A1
公开(公告)日：2022-10-06
申请号：US17713596
申请日：2022-04-05
发明人： Viktoria Molnar , Carolina Villarreal , Bhanu Prasanth Koppolu , Nivedita Swetha Ramkumar , Philip David Dorgan
摘要： The present disclosure pertains to therapeutic hydrogels that comprise an anionic polysaccharide crosslinked by a branched polyamine, wherein the branched polyamine comprises at least two primary amine groups, more typically at least three primary amine groups. The present disclosure also pertains to medical compositions that comprise such therapeutic hydrogels and to methods of medical treatment in which such therapeutic hydrogels are delivered to a patient in need of medical treatment.
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公开(公告)号：US20210236690A1
公开(公告)日：2021-08-05
申请号：US17165485
申请日：2021-02-02
发明人： Joseph T. Delaney, Jr. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
摘要： Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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