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公开(公告)号：US20240024670A1
公开(公告)日：2024-01-25
申请号：US18227021
申请日：2023-07-27
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Aleksandra Kharam
CPC classification number: A61N1/36002 , A61F7/007 , A61F2007/0073 , A61F2007/0096
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.
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公开(公告)号：US11607542B2
公开(公告)日：2023-03-21
申请号：US16855421
申请日：2020-04-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Jacob M. Ludwig , Aleksandra Kharam
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.
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公开(公告)号：US20200338345A1
公开(公告)日：2020-10-29
申请号：US16855433
申请日：2020-04-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Keith R. Maile , Sarah Melissa Gruba , William J. Linder
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit and control circuitry configured to control delivery of the one or more electric fields from the electric field generating circuit to the site of the cancerous tissue. An implantable lead is included having a lead body including a first electrical conductor disposed within the lead body, and a first electrode coupled to the lead body, the first electrode in electrical communication with the first electrical conductor, wherein the first electrical conductor forms part of an electrical circuit by which the electric fields from the electric field generating circuit are delivered to the site of the cancerous tissue, and the first electrode can include a conductive coil filar disposed around the lead body. Other embodiments are also included herein.
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公开(公告)号：US20200330758A1
公开(公告)日：2020-10-22
申请号：US16850728
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , Ron A. Balczewski , Aleksandra Kharam
Abstract: Embodiments herein relate to a method for treating a cancerous tumor located within a subject. The method can include applying one or more electric fields at or near a site of the cancerous tumor, where the cancerous tumor can include a cancerous cell population. The one or more applied electric fields are effective to delay mitosis and cause mitotic synchronization within a proportion of the cancerous cell population. The method can include removing the one or more electric fields to allow mitosis to proceed within the cancerous cell population. The method can include administering a chemotherapeutic agent to the subject after the one or more electric fields have been removed. Other embodiments are also included herein.
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公开(公告)号：US20250099751A1
公开(公告)日：2025-03-27
申请号：US18893371
申请日：2024-09-23
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Michael J. Lyden , Michael J. Kane , Tucker James Nelson
Abstract: Embodiments herein relate to implantable systems and methods for treatment of pancreatic cancer. In an embodiment, a method of treating pancreatic cancer is included, the method including inserting an electrical stimulation lead through the inferior vena cava, a hepatic vein, and into the portal vein via a transjugular intrahepatic portosystem shunt (TIPS). The method can further include inserting the electrical stimulation lead into at least one of the superior mesenteric vein and the splenic vein. The method can further include positioning electrodes on the lead within at least one of the superior mesenteric vein and the splenic vein and delivering one or more electric fields through the electrodes to a treatment zone including at least a portion of the pancreas. The electric fields can be at frequencies and a field strength effective to prevent and/or disrupt cellular mitosis in a cell.
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Patent Agency Ranking
公开(公告)号：US20250058104A1
公开(公告)日：2025-02-20
申请号：US18799398
申请日：2024-08-09
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Michael J. Lyden , Michael J. Kane , Tucker James Nelson
Abstract: Embodiments herein relate to implantable systems for cancer treatment and related methods. In an embodiment, an implantable system for cancer treatment is included having a plurality of implantable stimulation leads, a plurality of electric field therapy electrodes, a therapy output circuit, and control circuitry. The therapy output circuit can generate an electrical current for the plurality of electric field therapy electrodes to create one or more electric fields that are effective to prevent and/or disrupt cellular mitosis in a cell. The control circuitry can be configured to cause the electrical current to be distributed asymmetrically between working electrodes and counter electrodes amongst the plurality of electric field therapy electrodes. At least some of the plurality of electric field therapy electrodes are disposed on the plurality of implantable stimulation leads and in electrical communication with the therapy output circuit. Other embodiments are also included herein.
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公开(公告)号：US12109412B2
公开(公告)日：2024-10-08
申请号：US16850728
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , Ron A. Balczewski , Aleksandra Kharam
CPC classification number: A61N1/36002 , A61B10/02 , A61N5/0601 , A61P35/00
Abstract: Embodiments herein relate to a method for treating a cancerous tumor located within a subject. The method can include applying one or more electric fields at or near a site of the cancerous tumor, where the cancerous tumor can include a cancerous cell population. The one or more applied electric fields are effective to delay mitosis and cause mitotic synchronization within a proportion of the cancerous cell population. The method can include removing the one or more electric fields to allow mitosis to proceed within the cancerous cell population. The method can include administering a chemotherapeutic agent to the subject after the one or more electric fields have been removed. Other embodiments are also included herein.
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公开(公告)号：US11691006B2
公开(公告)日：2023-07-04
申请号：US16850712
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Aleksandra Kharam
IPC: A61N1/36 , A61B5/0538 , A61N1/05
CPC classification number: A61N1/36002 , A61B5/0538 , A61N1/05
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.
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公开(公告)号：US11420049B2
公开(公告)日：2022-08-23
申请号：US16850720
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Sarah Melissa Gruba , Tucker James Nelson , Aleksandra Kharam
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.
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公开(公告)号：US20200338346A1
公开(公告)日：2020-10-29
申请号：US16855448
申请日：2020-04-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Aleksandra Kharam
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.
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