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公开(公告)号：US20160263288A1
公开(公告)日：2016-09-15
申请号：US15068132
申请日：2016-03-11
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jacob Drew Edick , Jonathan S. Stinson
CPC classification number: A61L31/022 , A61F2/04 , A61F2/06 , A61F2/82 , A61F2240/001 , A61L31/148 , B21C23/002 , C22C23/02 , C22C23/06
Abstract: A bioerodible endoprosthesis includes a bioerodible body including an alloy comprising at least 85 weight percent magnesium and at least one high-melting-temperature element having a melting temperature of greater than 700° C. The alloy has a microstructure including equiaxed magnesium-rich phase grains and optionally high-melting-temperature intermetallic phases. The equiaxed magnesium-rich phase grains have an average grain diameter of less than or equal to 10 microns. High-melting-temperature intermetallic phases, if present, can have an average longest dimension of 3 microns or less.
Abstract translation: 生物腐蚀性内用假体包括含有包含至少85重量％的镁和至少一个熔点高于700℃的至少一个高熔点元素的合金的生物腐蚀体。该合金具有包括等轴富镁相晶粒 和任选的高熔点金属间相。 等轴富镁相晶粒的平均粒径小于或等于10微米。 高熔点金属间相（如果存在）可以具有3微米或更小的平均最长尺寸。
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公开(公告)号：US09603728B2
公开(公告)日：2017-03-28
申请号：US14178869
申请日：2014-02-12
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jonathan S. Stinson , Dennis A. Boismier , Jacob Drew Edick , Torsten Scheuermann , Louis Toth , Jan Webber , Charles Deng
CPC classification number: A61F2/82 , A61L31/022 , A61L31/14 , A61L31/148 , C22C23/02 , C22F1/06
Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
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3.发明申请Apparatus For Reducing Deployment Forces In A Self-Expanding Stent Delivery System 审中-公开用于减少自扩展支架输送系统中部署力的装置公开(公告)号：US20150297382A1
公开(公告)日：2015-10-22
申请号：US14691107
申请日：2015-04-20
Applicant: Boston Scientific Scimed Inc.
Inventor： Anthony Frank Tassoni, JR. , Martin R. Willard , Patrick A. Haverkost , Jonathan S. Stinson , Peter G. Edelman , Jacob Drew Edick
IPC: A61F2/962
CPC classification number: A61F2/966
Abstract: A stent delivery catheter comprising at least one catheter shaft, the catheter shaft having an inner surface and an outer surface and a distal end and a proximal end, the catheter shaft defining a guidewire lumen, the guidewire lumen comprising a diameter defined by the inner surface of the catheter shaft, a stent disposed within the distal end of the catheter shaft and in contact with the inner surface of the catheter shaft, and a stylet disposed within the distal end of the catheter shaft, the stylet comprising a wave geometry.
Abstract translation: 一种支架输送导管，其包括至少一个导管轴，所述导管轴具有内表面和外表面以及远端和近端，所述导管轴限定导丝管腔，所述导丝管腔包括由内表面限定的直径 所述导管轴设置在所述导管轴的远端内且与所述导管轴的内表面接触的支架以及设置在所述导管轴的远端内的探针，所述探针包括波形几何形状。
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公开(公告)号：US20150157767A1
公开(公告)日：2015-06-11
申请号：US14527317
申请日：2014-10-29
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jacob Drew Edick
CPC classification number: A61L31/022 , A61F2/86 , A61F2210/0004 , A61L31/026 , A61L31/148 , A61L2400/12 , C22C23/02 , C22C23/04 , C22C23/06 , C22F1/06 , Y10T428/12993
Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
Abstract translation: 生物腐蚀性内用假体包括生物腐蚀性镁合金，其包含50重量％至92重量％的镁，至少5.5重量％以上的一种或多种选自Ho，Er，Lu，Tb和Tm的元素，并且至少 2.0重量％以上的一种或多种选自Y，Nd和Gd的元素。 生物腐蚀性镁合金具有包括平均晶粒直径小于或等于15微米的等轴Mg富集固相晶粒的微结构，并且等轴富镁固体之间的晶界中的第二相析出物和/或陶瓷纳米颗粒 溶液相晶粒。 二次相析出物或陶瓷纳米颗粒的平均最长尺寸为2.0微米或更小。 微结构可通过一个或多个等通道高应变过程产生。
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公开(公告)号：US20150066135A1
公开(公告)日：2015-03-05
申请号：US14456254
申请日：2014-08-11
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jan Weber , Jacob Drew Edick
CPC classification number: A61L31/148 , A61F2/82 , A61L31/124 , A61L2400/12 , B21C23/001 , C22F1/06
Abstract: A bioerodible endoprosthesis includes a composite including a matrix comprising a bioerodible magnesium alloy and a plurality of ceramic nanoparticles within the matrix. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns. The microstructure can be produced by one or more equal-channel high-strain processes.
Abstract translation: 生物腐蚀性内用假体包括包含基质的复合物，所述基质包含生物可腐蚀的镁合金和所述基质内的多个陶瓷纳米颗粒。 生物腐蚀性镁合金具有包括平均粒径小于或等于5微米的等轴Mg富集固相晶粒的微结构。 微结构可通过一个或多个等通道高应变过程产生。
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Patent Agency Ranking
公开(公告)号：US10589005B2
公开(公告)日：2020-03-17
申请号：US15068132
申请日：2016-03-11
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jacob Drew Edick , Jonathan S. Stinson
Abstract: A bioerodible endoprosthesis includes a bioerodible body including an alloy comprising at least 85 weight percent magnesium and at least one high-melting-temperature element having a melting temperature of greater than 700° C. The alloy has a microstructure including equiaxed magnesium-rich phase grains and optionally high-melting-temperature intermetallic phases. The equiaxed magnesium-rich phase grains have an average grain diameter of less than or equal to 10 microns. High-melting-temperature intermetallic phases, if present, can have an average longest dimension of 3 microns or less.
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公开(公告)号：US10518001B2
公开(公告)日：2019-12-31
申请号：US15352111
申请日：2016-11-15
Applicant: Boston Scientific SciMed, Inc.
Inventor： Jacob Drew Edick
Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
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公开(公告)号：US20170072112A1
公开(公告)日：2017-03-16
申请号：US15358636
申请日：2016-11-22
Applicant: Boston Scientific SciMed, Inc.
Inventor： Jonathan S. Stinson , Dennis A. Boismier , Jacob Drew Edick , Torsten Scheuermann , Louis Toth , Jan Weber , Charles Deng
CPC classification number: A61F2/82 , A61L31/022 , A61L31/14 , A61L31/148 , C22C23/02 , C22F1/06
Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
Abstract translation: 生物腐蚀性内置假体包括生物腐蚀性镁合金。 生物腐蚀性镁合金具有包含平均粒径小于或等于5微米的等轴Mg富集固相晶粒的微观组织，并且在等轴富Mg固相晶粒之间的晶界中的第二相析出。 β相析出物的平均最长尺寸为0.5微米或更小。 微结构可通过一个或多个等通道高应变过程产生。
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公开(公告)号：US20170056562A1
公开(公告)日：2017-03-02
申请号：US15352111
申请日：2016-11-15
Applicant: Boston Scientific SciMed, Inc.
Inventor： Jacob Drew Edick
CPC classification number: A61L31/022 , A61F2/86 , A61F2210/0004 , A61L31/026 , A61L31/148 , A61L2400/12 , C22C23/02 , C22C23/04 , C22C23/06 , C22F1/06 , Y10T428/12993
Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
Abstract translation: 生物腐蚀性内用假体包括生物腐蚀性镁合金，其包含50重量％至92重量％的镁，至少5.5重量％以上的一种或多种选自Ho，Er，Lu，Tb和Tm的元素，并且至少 2.0重量％以上的一种或多种选自Y，Nd和Gd的元素。 生物腐蚀性镁合金具有包括平均晶粒直径小于或等于15微米的等轴Mg富集固相晶粒的微结构，并且等轴富镁固体之间的晶界中的第二相析出物和/或陶瓷纳米颗粒 溶液相晶粒。 二次相析出物或陶瓷纳米颗粒的平均最长尺寸为2.0微米或更小。 微结构可通过一个或多个等通道高应变过程产生。
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公开(公告)号：US09522220B2
公开(公告)日：2016-12-20
申请号：US14527317
申请日：2014-10-29
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jacob Drew Edick
CPC classification number: A61L31/022 , A61F2/86 , A61F2210/0004 , A61L31/026 , A61L31/148 , A61L2400/12 , C22C23/02 , C22C23/04 , C22C23/06 , C22F1/06 , Y10T428/12993
Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
Abstract translation: 生物腐蚀性内用假体包括生物腐蚀性镁合金，其包含50重量％至92重量％的镁，至少5.5重量％以上的一种或多种选自Ho，Er，Lu，Tb和Tm的元素，并且至少 2.0重量％以上的一种或多种选自Y，Nd和Gd的元素。 生物腐蚀性镁合金具有包括平均晶粒直径小于或等于15微米的等轴Mg富集固相晶粒的微结构，并且等轴富镁固体之间的晶界中的第二相析出物和/或陶瓷纳米颗粒 溶液相晶粒。 二次相析出物或陶瓷纳米颗粒的平均最长尺寸为2.0微米或更小。 微结构可通过一个或多个等通道高应变过程产生。
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