公开(公告)号：US20060189979A1

公开(公告)日：2006-08-24

申请号：US11197849

申请日：2005-08-05

申请人： Brady Esch ,  Bob McRae ,  Arthur Zikorus ,  Michael Mirizzi ,  Christopher Jones

发明人： Brady Esch ,  Bob McRae ,  Arthur Zikorus ,  Michael Mirizzi ,  Christopher Jones

IPC分类号： A61B18/14

CPC分类号： A61B18/08 ,  A61B18/082 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00791 ,  A61B2018/1405 ,  A61B2018/1425

摘要： An energy delivering probe is used for thermally coagulating and/or constricting hollow anatomical structures (HAS) including, but not limited to, blood vessels such as perforator veins. The probe includes a shaft and at least two electrodes where at least one of the electrodes has a perimeter that increases as it extends proximally.

公开(公告)号：US20070088346A1

公开(公告)日：2007-04-19

申请号：US11581596

申请日：2006-10-16

申请人： Michael Mirizzi ,  Arthur Zikorus ,  Brady Esch

发明人： Michael Mirizzi ,  Arthur Zikorus ,  Brady Esch

IPC分类号： A61B18/04

CPC分类号： A61N7/02 ,  A61B17/2251

摘要： A method of treating a perforator vein comprises applying ultrasound to the perforator vein and occluding the perforator vein with the ultrasound. An apparatus for treating blood vessels comprises an ultrasound emitter, wherein the ultrasound emitter is configured to emit ultrasound at multiple therapeutic ultrasound frequencies during a treatment cycle. The apparatus further comprises an acoustic coupler in sonic communication with the emitter, wherein the acoustic coupler has an acoustic coupling surface configured to contact a patient and facilitate delivery of ultrasound to the patient and wherein the acoustic coupler provides a conduction path for ultrasound from the emitter to the acoustic coupling surface. The apparatus further comprises an acoustic coupler containing a displaceable acoustic coupling material. The apparatus further comprises an acoustic coupler configured to vary the length of the conduction path in accordance with variation in the thickness of the acoustic coupling material disposed between the emitter and the acoustic coupling surface.

摘要翻译： 治疗穿孔静脉的方法包括将超声波应用于穿孔静脉并用超声波封堵穿孔静脉。 一种用于治疗血管的装置包括超声发射器，其中所述超声发射器被配置为在治疗周期期间以多个治疗超声频率发射超声波。 该装置还包括与发射器声音通信的声耦合器，其中声耦合器具有被配置为接触患者并且便于将超声波传送给患者的声学耦合表面，并且其中声学耦合器提供来自发射器的超声波的传导路径 到声耦合表面。 该装置还包括一个包含可位移声耦合材料的声耦合器。 该装置还包括声耦合器，其被配置为根据设置在发射器和声耦合表面之间的声耦合材料的厚度的变化来改变导电路径的长度。

公开(公告)号：US20070016272A1

公开(公告)日：2007-01-18

申请号：US11236316

申请日：2005-09-27

申请人： Russell Thompson ,  Arthur Zikorus ,  Fiona Sander ,  Vijay Dhaka ,  Brady Esch

发明人： Russell Thompson ,  Arthur Zikorus ,  Fiona Sander ,  Vijay Dhaka ,  Brady Esch

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61B18/082 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/20 ,  A61B18/24 ,  A61B90/39 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00132 ,  A61B2018/00636 ,  A61B2018/00666 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/046 ,  A61B2090/0811 ,  A61B2090/3925 ,  A61B2090/3937 ,  A61B2090/3945

摘要： A catheter includes multiple primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes a resistive element located at the working end of the catheter. Separation is maintained between the leads such that each lead can individually receive power. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery. Energy is applied until the diameter of the hollow anatomical structure is reduced to the point where occlusion is achieved. In one embodiment, a balloon is inflated to place the resistive elements into apposition with a hollow anatomical structure and to occlude the structure before the application of energy. The inflated balloon impairs blood flow and facilitates the infusion of saline, or medication, to the hollow anatomical structure in order to reduce the occurrence of coagulation and to improve the heating of the structure by the catheter.

摘要翻译： 导管包括多个主引线以输送用于结扎中空解剖结构的能量。 每个主引线包括位于导管工作端的电阻元件。 在引线之间保持分离，使得每个引线可以单独地接收电力。 导管可以包括用于容纳导丝或者允许流体输送的内腔。 施加能量直到中空解剖结构的直径减小到达到遮挡的程度。 在一个实施例中，气囊被充气以将电阻元件与中空的解剖结构相配合并且在施加能量之前封闭结构。 膨胀的气球损伤血液流动并促进将盐水或药物输注到中空解剖结构，以便减少凝血的发生并且通过导管改善结构的加热。

公开(公告)号：US20060293647A1

公开(公告)日：2006-12-28

申请号：US11472793

申请日：2006-06-22

申请人： Robert McRae ,  Michael Mirizzi ,  Brady Esch ,  Anna Prestezog ,  Todd Schoenberger ,  Halil Karabey ,  Jeff Zalewski

发明人： Robert McRae ,  Michael Mirizzi ,  Brady Esch ,  Anna Prestezog ,  Todd Schoenberger ,  Halil Karabey ,  Jeff Zalewski

IPC分类号： A61B18/04 ,  A61M31/00

CPC分类号： A61B18/18 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2218/002 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/0082 ,  A61M25/0084 ,  A61M2025/0087 ,  A61M2202/0007 ,  A61M2210/12

摘要： A catheter is usable to treat a hollow anatomical structure (HAS). The catheter comprises one or more shafts which extend away from a proximal end of the catheter toward a distal end thereof. The catheter further comprises an HAS constriction energy source located at or near the distal end of the catheter. The catheter further comprises at least one radially expandable transmural fluid delivery channel located in the catheter near the HAS constriction energy source.

公开(公告)号：US20070050000A1

公开(公告)日：2007-03-01

申请号：US11491067

申请日：2006-07-21

申请人： Brady Esch ,  Radit Tantisira ,  Russell Thompson ,  Brian Farley

发明人： Brady Esch ,  Radit Tantisira ,  Russell Thompson ,  Brian Farley

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61B18/082 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/20 ,  A61B18/24 ,  A61B90/39 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00132 ,  A61B2018/00636 ,  A61B2018/00666 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/046 ,  A61B2090/0811 ,  A61B2090/3925 ,  A61B2090/3937 ,  A61B2090/3945

摘要： A working end of a catheter includes at least one therapeutic element, such as a resistive heating element, usable to deliver energy for ligating, or reducing the diameter of, a hollow anatomical structure. In certain examples, the catheter includes a lumen to accommodate a guide wire or to allow fluid delivery. In certain embodiments, a balloon is inflated to place resistive element(s) into apposition with a hollow anatomical structure and to occlude the structure. Indexing devices and methods are also disclosed for successively treating portions of the hollow anatomical structure. In certain examples, marks along the catheter shaft provide visual verification to the physician of the relative position of the therapeutic element of the catheter. Embodiments of indexing devices may include pairs of rings and/or hinged arms that move a catheter a desired indexed position between successive treatments.

摘要翻译： 导管的工作端包括至少一个治疗元件，例如电阻加热元件，其可用于递送用于结扎或减小中空解剖结构的直径的能量。 在某些实例中，导管包括用于容纳引导线或允许流体输送的内腔。 在某些实施例中，气囊被充气以将电阻元件放置成与中空解剖结构并置并阻塞结构。 还公开了分级装置和方法，用于连续处理中空解剖结构的部分。 在某些实例中，沿着导管轴的标记为医师提供导管治疗元件的相对位置的视觉验证。 分度装置的实施例可以包括成对的环和/或铰链臂，其使导管在连续的处理之间移动期望的分度位置。

公开(公告)号：US20050004503A1

公开(公告)日：2005-01-06

申请号：US10897491

申请日：2004-07-23

申请人： Wilfred Samson ,  Janine Robinson ,  Brady Esch

发明人： Wilfred Samson ,  Janine Robinson ,  Brady Esch

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61F2/958 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61M25/00 ,  A61M29/02 ,  A61M37/00

CPC分类号： A61M25/1011 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/12127 ,  A61F7/12 ,  A61F2007/126 ,  A61M1/3613 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M2025/1015 ,  A61M2025/1095 ,  A61M2205/366 ,  A61M2210/125 ,  A61M2210/127

摘要： An apparatus and method are described for quickly inducing therapeutic hypothermia of the heart by perfusing the myocardium with hypothermic fluid in alternatingly antegrade and retrograde directions. The apparatus and method provide rapid cooling of the affected myocardium to achieve optimal myocardial salvage in a patient experiencing acute myocardial infarction. The therapeutic hypothermia system includes one or more coronary artery perfusion catheters, a coronary sinus perfusion catheter and a fluid source for delivering a hypothermically-cooled physiologically-acceptable fluid, such as saline solution, oxygenated venous blood, autologously-oxygenated arterial blood and/or an oxygenated blood substitute. The system may also include one or more guidewires, subselective catheters and/or interventional catheters introduced through a lumen in one or more of the perfusion catheters.

摘要翻译： 描述了一种装置和方法，用于通过在交替顺行和逆行方向上用低温流体灌注心肌来快速诱导心脏的治疗低温。 该装置和方法提供受影响的心肌的快速冷却，以在经历急性心肌梗塞的患者中实现最佳的心肌救助。 治疗低温系统包括一个或多个冠状动脉灌注导管，冠状窦灌注导管和用于递送低温生理学上可接受的流体的流体源，例如盐水溶液，含氧静脉血，自体氧合的动脉血和/或 氧合血液替代品。 该系统还可以包括通过一个或多个灌注导管中的内腔引入的一个或多个导线，子选择性导管和/或介入导管。

公开(公告)号：US06702773B1

公开(公告)日：2004-03-09

申请号：US09495632

申请日：2000-02-01

申请人： John Macoviak ,  Brady Esch ,  Mike Lee ,  Wilfred J. Samson

发明人： John Macoviak ,  Brady Esch ,  Mike Lee ,  Wilfred J. Samson

IPC分类号： A61M3700

CPC分类号： A61M1/3653 ,  A61M1/1698 ,  A61M1/3613 ,  A61M1/3659 ,  A61M1/3666

摘要： A system for establishing differential perfusion without the use of an occlusion balloon or other flow separator devices. The flows through two lumens are controlled such that the blood flow issuing from one lumen terminating in the aortic arch supplies the entire demand of the cerebral subcirculation while the blood flow issuing from a second lumen terminating in the descending aorta supplies the entire demand of the corporeal subcirculation. When the two flows are properly balanced, an inversion layer forms therebetween and no intermixing of the two flows takes place.

摘要翻译： 用于在不使用闭塞气囊或其它流动分离器装置的情况下建立差异灌注的系统。 控制通过两个流明的流动，使得从终止于主动脉弓的一个腔中发出的血流提供了大脑亚循环的整个需求，而从下降的主动脉终止的第二个腔中发出的血流提供了整个体表的需求 亚循环。 当两个流动适当地平衡时，在其间形成反转层，并且不会发生两个流动的混合。

公开(公告)号：US06673042B1

公开(公告)日：2004-01-06

申请号：US09447457

申请日：1999-11-22

申请人： Wilfred J. Samson ,  Brady Esch ,  Michael J. Lee ,  Janine Robinson

发明人： Wilfred J. Samson ,  Brady Esch ,  Michael J. Lee ,  Janine Robinson

IPC分类号： A61M2900

CPC分类号： A61M29/02

摘要： The cannula of the present invention is useful for standard gravity drainage or vacuum assisted/suction drainage. The cannula of the present invention has a flexible shaft composed of a tubular body and an expandable scaffolding. The expandable scaffolding has a contracted position, facilitating insertion into a vessel and an expanded condition configured to allow optimal drainage in a vessel. The cannula is inserted into a vessel and navigated into an operative position within the patient's venous system. Once the cannula is in the proper position, the scaffolding is expanded either through passive, active, mechanic, hydraulic, pneumatic, thermal or electrical actuation. The cannula of the present invention is capable of expanding a collapsed vein to its normal diameter and/or capable of supporting the vein when suction is applied to the cannula to help increase fluid flow through the cannula.

摘要翻译： 本发明的套管可用于标准重力排水或真空辅助/抽吸排水。 本发明的插管具有由管状体和可扩展脚手架组成的柔性轴。 可膨胀的脚手架具有收缩位置，便于插入容器中，并且膨胀状态被配置为允许容器中的最佳排水。 将套管插入血管并导航到患者静脉系统内的操作位置。 一旦插管处于适当的位置，脚手架就可以通过被动，主动，机械，液压，气动，热或电致动来扩展。 本发明的插管能够将收缩的静脉膨胀至其正常直径和/或能够在将抽吸施加到套管上时支撑静脉，以帮助增加通过插管的流体流动。

公开(公告)号：US5701905A

公开(公告)日：1997-12-30

申请号：US557753

申请日：1995-11-13

申请人： Brady Esch

发明人： Brady Esch

IPC分类号： A61B5/0215 ,  A61B5/028 ,  A61M25/00 ,  A61B5/02

CPC分类号： A61B5/028 ,  A61B5/0215 ,  A61M2025/0002

摘要： A guide catheter includes a tubular body having a proximal end and a distal end. A pressure or other sensor is disposed at or near the distal end of the body, preferably having an active surface thereof disposed away from the direction of blood flow when the catheter is present in a particular blood vessel, such as the aorta adjacent to a coronary ostium.

摘要翻译： 引导导管包括具有近端和远端的管状体。 压力或其他传感器设置在身体的远端处或附近，当导管存在于特定血管中时，优选地具有远离血流方向的活动表面，例如与冠状动脉相邻的主动脉 口腔

公开(公告)号：US20070100405A1

公开(公告)日：2007-05-03

申请号：US11491348

申请日：2006-07-21

申请人： Russell Thompson ,  Brady Esch ,  Robert McRae ,  Michael Abelmann ,  Brian Farley ,  Vijay Dhaka ,  Fiona Sander

发明人： Russell Thompson ,  Brady Esch ,  Robert McRae ,  Michael Abelmann ,  Brian Farley ,  Vijay Dhaka ,  Fiona Sander

IPC分类号： A61F7/12

CPC分类号： A61B18/082 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/20 ,  A61B18/24 ,  A61B90/39 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00132 ,  A61B2018/00636 ,  A61B2018/00666 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/046 ,  A61B2090/0811 ,  A61B2090/3925 ,  A61B2090/3937 ,  A61B2090/3945

摘要： A working end of a catheter includes at least one therapeutic element, such as a resistive heating element, usable to deliver energy for ligating, or reducing the diameter of, a hollow anatomical structure. In certain examples, the catheter includes a lumen to accommodate a guide wire or to allow fluid delivery. In certain embodiments, a balloon is inflated to place resistive element(s) into apposition with a hollow anatomical structure and to occlude the structure. Indexing devices and methods are also disclosed for successively treating portions of the hollow anatomical structure. In certain examples, marks along the catheter shaft provide visual verification to the physician of the relative position of the therapeutic element of the catheter. Embodiments of indexing devices may include pairs of rings and/or hinged arms that move a catheter a desired indexed position between successive treatments.

摘要翻译： 导管的工作端包括至少一个治疗元件，例如电阻加热元件，其可用于递送用于结扎或减小中空解剖结构的直径的能量。 在某些实例中，导管包括用于容纳引导线或允许流体输送的内腔。 在某些实施例中，气囊被充气以将电阻元件放置成与中空解剖结构并置并阻塞结构。 还公开了分级装置和方法，用于连续处理中空解剖结构的部分。 在某些实例中，沿着导管轴的标记为医师提供导管治疗元件的相对位置的视觉验证。 分度装置的实施例可以包括成对的环和/或铰链臂，其使导管在连续的处理之间移动期望的分度位置。