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10 条记录 (耗时 0.012 秒)

    Process for the preparation of compounds having an ace inhibitory action
    1.
    发明申请
    Process for the preparation of compounds having an ace inhibitory action 失效
    具有抑制作用的化合物的制备方法

    公开(公告)号：US20070072919A1

    公开(公告)日：2007-03-29

    申请号：US10556986

    申请日：2004-05-07

    申请人： Branko Jenko

    发明人： Branko Jenko

    IPC分类号： A61K31/427 ,  A61K31/4184 ,  A61K31/4178 ,  A61K31/405 ,  C07D403/02 ,  C07D417/02

    CPC分类号： C07D207/16 ,  C07D209/42

    摘要： The present invention relates to the process for the preparation of compounds of formula (I) having an ACE inhibitory action wherein carboxy group of stereospecific amino acid is activated with an uranium salt in the presence of an aprotic solvent and an activated amino acid is further transformed with appropriate amine into ACE inhibitor or its precursor.

    摘要翻译： 本发明涉及制备具有ACE抑制作用的式（I）化合物的方法，其中立体特异性氨基酸的羧基在非质子溶剂和活化的氨基酸存在下用铀盐活化，进一步转化 用适当的胺转化成ACE抑制剂或其前体。

    Process for the preparation of compounds having an ace inhibitory action
    2.
    发明授权
    Process for the preparation of compounds having an ace inhibitory action 失效
    具有抑制作用的化合物的制备方法

    公开(公告)号：US07671215B2

    公开(公告)日：2010-03-02

    申请号：US10556986

    申请日：2004-05-07

    申请人： Branko Jenko

    发明人： Branko Jenko

    IPC分类号： C07D207/00 ,  C07D209/42

    CPC分类号： C07D207/16 ,  C07D209/42

    摘要： The present invention relates to the process for the preparation of compounds of formula (I) having an ACE inhibitory action wherein carboxy group of stereospecific amino acid is activated with an uranium salt in the presence of an aprotic solvent and an activated amino acid is further transformed with appropriate amine into ACE inhibitor or its precursor.

    摘要翻译： 本发明涉及制备具有ACE抑制作用的式（I）化合物的方法，其中立体特异性氨基酸的羧基在非质子溶剂和活化的氨基酸存在下用铀盐活化，进一步转化 用适当的胺转化成ACE抑制剂或其前体。

    Process for the preparation of crystalline perindopril
    4.
    发明授权
    Process for the preparation of crystalline perindopril 失效
    制备结晶培哚普利的方法

    公开(公告)号：US07923570B2

    公开(公告)日：2011-04-12

    申请号：US11996438

    申请日：2006-07-24

    申请人： Branko Jenko ,  Anton Copar

    发明人： Branko Jenko ,  Anton Copar

    IPC分类号： C07D209/04

    CPC分类号： C07K5/06026 ,  C07D209/42

    摘要： The present invention relates to a new process for the preparation of crystalline perindopril. The present invention also relates to new alkyl ammonium salts of perindopril and the processes for the preparation thereof.

    摘要翻译： 本发明涉及一种制备结晶培哚普利的新方法。 本发明还涉及培哚普利的新的烷基铵盐及其制备方法。

    Process for preparing a 1,4-dihydropyridine derivative
    6.
    发明授权
    Process for preparing a 1,4-dihydropyridine derivative 失效
    1,4-二氢吡啶衍生物的制备方法

    公开(公告)号：US4467093A

    公开(公告)日：1984-08-21

    申请号：US402487

    申请日：1982-07-27

    申请人： Branko Jenko ,  Igor Langof

    发明人： Branko Jenko ,  Igor Langof

    IPC分类号： A61K31/4418 ,  A61K31/4422 ,  A61P9/10 ,  B01J31/00 ,  C07D211/90 ,  C07D213/55

    CPC分类号： C07D211/90

    摘要： In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy-1,4-dihydropyridine of the formula ##STR1## 2-nitrobenzaldehyd-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20.degree. and 150.degree. C. The compound is a valuable medicine for the treatment of angina pectoris.

    摘要翻译： 在制备下式的4-（2'-硝基苯基-2,6-二甲基）-3,5-二甲氧基-1,4-二氢吡啶的方法中，将2-乙酰乙酸甲酯和氨反应在 在惰性有机溶剂如甲醇的存在下，在有机碱如吡啶存在或不存在的情况下，温度为20-150℃。该化合物是用于治疗心绞痛的有价值的药物 胸腺

    PROCESS FOR DIMETHYLATION OF ACTIVE METHYLENE GROUPS
    7.
    发明申请
    PROCESS FOR DIMETHYLATION OF ACTIVE METHYLENE GROUPS 审中-公开
    活性甲基团二甲基化方法

    公开(公告)号：US20120149895A1

    公开(公告)日：2012-06-14

    申请号：US13262587

    申请日：2010-03-30

    申请人： Branko Jenko ,  Anton Copar

    发明人： Branko Jenko ,  Anton Copar

    IPC分类号： C07C231/14 ,  C07D273/00 ,  C07C253/30

    CPC分类号： C07C253/30 ,  C07C231/12 ,  C07C237/06 ,  C07C255/19

    摘要： The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide can be used as intermediates in the route of synthesis of therapeutic, prophylactic or diagnostic agent, for example aliskiren or cryptophycin. Particularly, the invention relates to embodiments further extending to processes for preparing pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention can be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or crypthophycin.

    摘要翻译： 本发明公开了一种活性亚甲基二甲基化方法。 具体地说，本发明公开了一种制备3-氨基-2,2-二甲基丙酰胺的方法。 通过本发明的二甲基化方法制备的化合物如3-氨基-2,2-二甲基丙酰胺可用作合成治疗，预防或诊断剂例如阿利吉仑或隐霉素的途径中的中间体。 特别地，本发明涉及进一步扩展到制备包含所述治疗剂，预防剂或诊断剂的药物剂型的方法的实施方案。 更具体地，本发明涉及通过本发明的二甲基化方法制备的化合物在制备治疗，预防或诊断剂中的用途，或用于制备包含所述治疗，预防或诊断剂的药物剂型。 根据本发明的方法可有利地用于合成各种活性药物成分，例如阿利吉仑或crypthophycin。