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公开(公告)号：US20070158360A1
公开(公告)日：2007-07-12
申请号：US11649576
申请日：2007-01-04
申请人： Robert Saunders , Brett Belongia
发明人： Robert Saunders , Brett Belongia
CPC分类号： B67D1/0804 , B67D1/0054 , B67D2001/0827 , Y10T137/0324
摘要： Reservoir for a dispense system designed to maintain a suspending fluid flow within the reservoir. The fluid dispense system is particularly well suited to be manufactured in a single-use format comprising a fluid reservoir and fill tube assembly, particularly comprising a reservoir, tubing, fittings and connectors, and a needle. The system ensures uniformity within the liquid by moving the fluid through the product reservoir such as with a continuous or pulsating flow, and is designed to maintain the fluid in motion in order to maintain a homogenous solution. The reservoir is designed to minimize any fluid dead zones.
摘要翻译： 用于分配系统的储存器，其设计用于在储存器内保持悬浮液流动。 流体分配系统特别适合于以一次性格式制造，包括流体储存器和填充管组件，特别地包括储存器，管道，配件和连接器以及针头。 该系统通过使流体通过产品储存器例如连续或脉动的流动来确保液体内的均匀性，并且被设计成保持流体运动以维持均匀的溶液。 储存器设计成使任何流体死区最小化。
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公开(公告)号：US20070023449A1
公开(公告)日：2007-02-01
申请号：US11189358
申请日：2005-07-26
申请人： Brett Belongia , Robert Saunders
发明人： Brett Belongia , Robert Saunders
IPC分类号： B67D5/08
CPC分类号： G01F11/125 , B01F5/102 , B01F5/104 , B01F11/0071 , B01F11/0074 , B01F15/00123 , B01F15/00155 , B01F15/00883 , B01F15/0201 , B01F15/0245 , B01F2003/0028 , B01F2003/0035 , B01F2215/0032
摘要： A dispense apparatus and system for dispensing suspensions or emulsions. The system ensures uniformity of distribution of the dispersed phase within the continuous-phase liquid by moving the fluid through the dispense cartridge, such as with a continuous or pulsating flow. In one embodiment, peristaltic pumps are positioned upstream and downstream of the dispense cartridge, in fluid communication with and forming a single loop with a fluid source. Circulation between the fluid source and the dispense cartridge is maintained. In a second embodiment, a pump circulates fluid into and out of the dispense cartridge and is also in fluid communication with a fluid source such as with a pinch valve to allow proper filling of the dispense cartridge from the fluid source. In a third embodiment, a reversing pump is placed between the dispense cartridge and fluid source to continually or continuously pump fluid into and out of the dispense cartridge.
摘要翻译： 用于分配悬浮液或乳液的分配装置和系统。 该系统通过使流体通过分配筒（例如连续或脉动流）移动来确保分散相在连续相液体中的分布均匀性。 在一个实施例中，蠕动泵定位在分配盒的上游和下游，与流体源流体连通并形成具有流体源的单个环。 保持流体源和分配盒之间的循环。 在第二实施例中，泵将流体循环进入和排出分配盒，并且还与诸如用夹管阀的流体源流体连通，以允许从流体源适当地填充分配盒。 在第三实施例中，反转泵被放置在分配卡盘和流体源之间，以连续或连续地将流体泵入和分出泵。
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公开(公告)号：US20050029301A1
公开(公告)日：2005-02-10
申请号：US10635124
申请日：2003-08-06
申请人： Brett Belongia , Stephen Proulx
发明人： Brett Belongia , Stephen Proulx
CPC分类号： G01F11/284 , B01L3/0293 , G01N35/1002 , G01N35/1016 , Y10T137/86324
摘要： A single-use fluid dispenser cartridge, installable or installed into a host fluid dispensing apparatus, is described. The single-use fluid dispenser cartridge is provided with a fluid reservoir, a fill tube assembly, and means for controlling pressure within the cartridge by gating gas into or out of the reservoir and/or the fill tube assembly. The gas gating mean enables, in certain embodiments, use of a fluid reservoir that is “substantially rigid”.
摘要翻译： 描述可安装或安装在主体流体分配装置中的一次性流体分配器盒。 一次性流体分配器盒设置有流体储存器，填充管组件和用于通过将气体进入或流出储存器和/或填充管组件来控制筒内的压力的装置。 在某些实施例中，气体门控装置能够使用“基本刚性”的流体储存器。
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公开(公告)号：US20080131959A1
公开(公告)日：2008-06-05
申请号：US11978911
申请日：2007-10-30
申请人： Brett Belongia , Neil Schauer
发明人： Brett Belongia , Neil Schauer
IPC分类号： C12M1/00
摘要： A bioreactor formed of a flexible material is provided having a constant aspect ratio and an adjustable length.
摘要翻译： 提供由柔性材料形成的生物反应器，其具有恒定的纵横比和可调整的长度。
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公开(公告)号：US20060272432A1
公开(公告)日：2006-12-07
申请号：US11441910
申请日：2006-05-26
申请人： Brett Belongia
发明人： Brett Belongia
IPC分类号： G01N1/20
CPC分类号： G01N1/10 , G01N1/18 , G01N1/2035 , G01N2001/1031 , G01N2001/1056
摘要： The present invention provides fluid sampling device comprising a sampling head having a series of openings through it from one major surface to the other, a plurality of conduits at the downstream side of the openings and a plurality of sample containers. The openings are selectively opened and closed through the use of switches mounted within each opening and the head of the device members, each switch being movable within said head between closed and open positions. The conduits (e.g., flexible tubing) are equal in number to the openings, with each conduit connected to an individual port fitting arranged on a face of the head downstream of the respective opening. Similarly, the sample containers (e.g., flexible bags) are equal in number to the conduits, with each sample container connected to an individual conduit opposite the connection to the port. A specific configuration for the device, as well as a kit containing pre-sterilized components of the fluid sampling device, are also described.
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公开(公告)号：US20050090797A1
公开(公告)日：2005-04-28
申请号：US10626282
申请日：2003-07-24
申请人： Joseph Almasian , Brett Belongia , Frank Lentine , Martin Morrissey , Curtis Nauseda , Chau Nguyen , Stephen Proulx , Naren Renganath
发明人： Joseph Almasian , Brett Belongia , Frank Lentine , Martin Morrissey , Curtis Nauseda , Chau Nguyen , Stephen Proulx , Naren Renganath
CPC分类号： F16L29/007 , A61M39/14 , A61M39/18 , A61M39/22 , F16L2201/44 , G01N1/2035 , G01N2001/205 , G01N2001/2071 , Y10S604/905 , Y10T137/87925
摘要： A sterile to sterile connection device comprising a connector and one or more coupling devices. The connector has body portion which has two openings sealed from the environment so as to form a sterile environment within the connector. At least one of the openings being sealed from the environment by a sterile barrier plug. The connector also has a port capable movement within the body of the connector to at least an open and a closed position. The coupling device is formed of a body having two openings and a stem having a bore through at least a portion of the stem. The stem is contained within the body and capable of moving at least linearly through the body between a first and second stem position. One of the openings of the stem is sealed from the environment by a sterile barrier plug and the other is sealed to a presterilized component. The coupling device opening containing the sterile barrier plug is attached to either the inlet or outlet of the connector.
摘要翻译： 一种无菌至无菌连接装置，包括连接器和一个或多个联接装置。 连接器具有主体部分，其具有与环境密封的两个开口，以便在连接器内形成无菌环境。 至少一个开口通过无菌隔离塞与环境密封。 连接器还具有能够在连接器主体内移动至少至少一个打开和关闭位置的端口。 联接装置由具有两个开口的主体和具有穿过杆的至少一部分的孔的杆构成。 杆体容纳在主体内并且能够至少在第一和第二杆位置之间线性移动通过主体。 杆的一个开口通过无菌阻塞塞与环境密封，另一个被密封到预先灭活的部件上。 包含无菌阻塞塞的联接装置开口连接到连接器的入口或出口。
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公开(公告)号：US20080138891A1
公开(公告)日：2008-06-12
申请号：US11978761
申请日：2007-10-30
申请人： Brett Belongia , Neil Schauer
发明人： Brett Belongia , Neil Schauer
IPC分类号： C12M1/04
摘要： A bioreactor formed of a material such as glass or plastic is provided having a first closed wall spaced apart from a second closed wall. At least a portion of the height of the first closed wall extends toward the center of the bioreactor so that gas introduced at the bioreactor bottom contacts the first closed wall prior to contacting the top surface of reactants in the bioreactor.
摘要翻译： 提供由诸如玻璃或塑料的材料形成的生物反应器，其具有与第二封闭壁间隔开的第一封闭壁。 第一封闭壁的高度的至少一部分朝向生物反应器的中心延伸，使得在生物反应器的反应物的顶表面接触之前，在生物反应器底部引入的气体接触第一封闭壁。
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公开(公告)号：US20080131960A1
公开(公告)日：2008-06-05
申请号：US11978913
申请日：2007-10-30
申请人： Brett Belongia , Neil Schauer , Stephen Proulx
发明人： Brett Belongia , Neil Schauer , Stephen Proulx
IPC分类号： C12M1/00
摘要： A bioreactor formed of a flexible material is provided having a constant aspect ratio and an adjustable length. The bioreactor is rendered self standing by a support means secured to the bioreactor.
摘要翻译： 提供由柔性材料形成的生物反应器，其具有恒定的纵横比和可调整的长度。 生物反应器通过固定在生物反应器上的支撑装置使其自我站立。
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9.发明申请Constant temperature disposable reservoir for use with volumetric fluid dispensing apparatus 审中-公开恒温一次性容器用于体积流体分配装置公开(公告)号：US20050284882A1
公开(公告)日：2005-12-29
申请号：US10879568
申请日：2004-06-28
申请人： Brett Belongia
发明人： Brett Belongia
CPC分类号： G01F11/284 , B67D7/08 , G01F11/006 , G01N35/10 , G01N2035/00425
摘要： A system and method for controlling the temperature of the fluid in a volumetric dispensing apparatus, without the need for a controlled ambient environment. The reservoir used to hold the fluid prior to dispensing is maintained at a constant temperature through the use of a temperature-controlled surround, such as a water jacket. This ensures uniform fluid properties, such as viscosity and density, thereby guaranteeing that accurate volumes will be dispensed. Methods for controlling the temperature within the encased reservoir are also disclosed.
摘要翻译： 一种用于在体积分配装置中控制流体温度的系统和方法，而不需要受控的环境环境。 用于在分配前保持流体的储存器通过使用温度控制的环绕（例如水套）而保持在恒定温度。 这确保了均匀的流体性质，例如粘度和密度，从而保证将分配精确的体积。 还公开了用于控制封装储存器内的温度的方法。
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