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1.发明授权Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device 有权使用声学装置检测雌二醇及其代谢物的方法和装置公开(公告)号：US07615381B2
公开(公告)日：2009-11-10
申请号：US11417000
申请日：2006-05-02
申请人： Brett P. Masters , Michael Miller , Vishal K. Gulati , Mark Lundstrom , Alok Srivastava , Wayne U. Wang
发明人： Brett P. Masters , Michael Miller , Vishal K. Gulati , Mark Lundstrom , Alok Srivastava , Wayne U. Wang
IPC分类号： G01N33/553 , B32B27/00 , B32B27/12
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324 , Y02A50/52 , Y02A50/57
摘要： Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of estradiol-particle complexes that are bound to the sensor surface.
摘要翻译： 提供了检测样品中雌二醇及其代谢物的方法。 将多个颗粒，每个颗粒涂覆有对雌二醇具有亲和性的捕获剂，与样品组合以形成多个雌二醇 - 颗粒复合物。 该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的雌二醇 - 颗粒复合物的量的信号。
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2.发明申请Methods and apparatus for therapeutic drug monitoring using an acoustic device 有权使用声学装置的治疗药物监测的方法和装置公开(公告)号：US20090148856A1
公开(公告)日：2009-06-11
申请号：US11416624
申请日：2006-05-02
IPC分类号： G01N33/53
CPC分类号： G01N29/4418 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N33/54313 , G01N33/9493 , G01N2291/0256 , G01N2291/02836 , G01N2291/0427 , G01N2800/324
摘要： Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the sample to form a plurality of therapeutic drug-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of therapeutic drug-particle complexes that are bound to the sensor surface.
摘要翻译： 提供治疗药物监测的方法。 将能够结合选择的治疗药物的捕获剂的多个颗粒与样品组合以形成多个治疗药物 - 颗粒复合物。 该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的治疗药物 - 颗粒复合物的量的信号。
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公开(公告)号：US07648844B2
公开(公告)日：2010-01-19
申请号：US11416789
申请日：2006-05-02
IPC分类号： G01N33/553 , B32B27/00 , B32B27/12
CPC分类号： G01N29/022 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/036 , G01N29/4418 , G01N33/54313 , G01N33/9493 , G01N2291/0256 , G01N2291/0427 , G01N2800/324
摘要： Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译： 提供了检测样品中分析物的方法。 将多个颗粒（每个颗粒涂覆有对分析物具有亲和性的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的传送装置，以及构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。
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4.发明授权Method and apparatus for therapeutic drug monitoring using an acoustic device 有权使用声学装置进行治疗药物监测的方法和装置公开(公告)号：US07611908B2
公开(公告)日：2009-11-03
申请号：US11416624
申请日：2006-05-02
IPC分类号： G01N33/553 , B32B27/00 , B32B27/12
CPC分类号： G01N29/4418 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N33/54313 , G01N33/9493 , G01N2291/0256 , G01N2291/02836 , G01N2291/0427 , G01N2800/324
摘要： Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the sample to form a plurality of therapeutic drug-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of therapeutic drug-particle complexes that are bound to the sensor surface.
摘要翻译： 提供治疗药物监测的方法。 将能够结合选择的治疗药物的捕获剂的多个颗粒与样品组合以形成多个治疗药物 - 颗粒复合物。 该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的治疗药物 - 颗粒复合物的量的信号。
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公开(公告)号：US20090148857A1
公开(公告)日：2009-06-11
申请号：US11416789
申请日：2006-05-02
IPC分类号： G01N33/53 , G01N33/553
CPC分类号： G01N29/022 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/036 , G01N29/4418 , G01N33/54313 , G01N33/9493 , G01N2291/0256 , G01N2291/0427 , G01N2800/324
摘要： Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译： 提供了检测样品中分析物的方法。 将多个颗粒（每个颗粒涂覆有对分析物具有亲和性的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的传送装置，以及构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。
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公开(公告)号：US08354280B2
公开(公告)日：2013-01-15
申请号：US12205595
申请日：2008-09-05
申请人： Jaime E. Arenas , Hyun-Goo Choi , William Matthew Dickerson , Sarah Beth Hembree , Lara Louise Madison , Brett P. Masters , Michael F. Miller , Wayne U. Wang
发明人： Jaime E. Arenas , Hyun-Goo Choi , William Matthew Dickerson , Sarah Beth Hembree , Lara Louise Madison , Brett P. Masters , Michael F. Miller , Wayne U. Wang
IPC分类号： G01N33/551
CPC分类号： G01N29/022 , B01L9/52 , G01N33/54373 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2291/02836 , G01N2291/0427
摘要： The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte.
摘要翻译： 本文提供的技术通常涉及可重复使用的检测表面和用于在分析物的测定中使用检测表面后重新使用检测表面的方法。
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公开(公告)号：US20090068759A1
公开(公告)日：2009-03-12
申请号：US12205595
申请日：2008-09-05
申请人： Jamie E. Arenas , Hyun-Goo Choi , William Matthew Dickerson , Sarah Beth Hembree , Lara Louise Madison , Brett P. Masters , Michael F. Miller , Wayne U. Wang
发明人： Jamie E. Arenas , Hyun-Goo Choi , William Matthew Dickerson , Sarah Beth Hembree , Lara Louise Madison , Brett P. Masters , Michael F. Miller , Wayne U. Wang
IPC分类号： G01N33/543
CPC分类号： G01N29/022 , B01L9/52 , G01N33/54373 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2291/02836 , G01N2291/0427
摘要： The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte.
摘要翻译： 本文提供的技术通常涉及可重复使用的检测表面和用于在分析物的测定中使用检测表面后重新使用检测表面的方法。
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