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    Antisense oligonucleotide modulation of raf gene expression
    1.
    发明授权
    Antisense oligonucleotide modulation of raf gene expression 有权
    raf基因表达的反义寡核苷酸调控

    公开(公告)号：US06090626A

    公开(公告)日：2000-07-18

    申请号：US143214

    申请日：1998-08-28

    申请人： Brett P. Monia ,  Russell T. Boggs

    发明人： Brett P. Monia ,  Russell T. Boggs

    IPC分类号： A61K38/00 ,  C12N15/113 ,  A61K31/70 ,  C07H21/00 ,  C12N5/06

    CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3517

    摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

    摘要翻译： 提供寡核苷酸，其靶向编码人raf的核酸并能够抑制raf表达。 在优选的实施方案中，将寡核苷酸靶向编码人c-raf或人A-raf的mRNA。 寡核苷酸可以在一个或多个位置具有化学修饰，并且可以是嵌合寡核苷酸。 还提供了使用本发明的寡核苷酸抑制人raf表达的方法。 本发明还包括抑制细胞过度增殖的方法和使用本发明寡核苷酸处理异常增殖病症的方法。

    Antisense oligonucleotide modulation of raf gene expression
    2.
    发明授权
    Antisense oligonucleotide modulation of raf gene expression 失效

    公开(公告)号：US5952229A

    公开(公告)日：1999-09-14

    申请号：US756806

    申请日：1996-11-26

    申请人： Brett P. Monia ,  Russell T. Boggs

    发明人： Brett P. Monia ,  Russell T. Boggs

    IPC分类号： C12N5/22 ,  C12N15/113 ,  A61K31/70 ,  C07H21/00

    CPC分类号： C12N15/1135

    摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

    Antisense oligonucleotide modulation of raf gene expression
    3.
    发明授权
    Antisense oligonucleotide modulation of raf gene expression 失效
    raf基因表达的反义寡核苷酸调控

    公开(公告)号：US5563255A

    公开(公告)日：1996-10-08

    申请号：US250856

    申请日：1994-05-31

    申请人： Brett P. Monia ,  Russell T. Boggs

    发明人： Brett P. Monia ,  Russell T. Boggs

    IPC分类号： C07H21/04 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00 ,  C07H21/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68

    CPC分类号： C12N15/1137 ,  C07H21/00 ,  C12N15/1135 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3517

    摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of detecting the presence of a raf gene using oligonucleotides of the invention, including methods for specific detection of activated truncated raf. Methods of inhibiting hyperproliferation of cells and methods of treating conditions arising from abnormal raf expression which employ oligonucleotides of the invention are also provided.

    摘要翻译： 提供寡核苷酸，其靶向编码人raf的核酸并能够抑制raf表达。 在优选的实施方案中，将寡核苷酸靶向编码人c-raf或人A-raf的mRNA。 寡核苷酸可以在一个或多个位置具有化学修饰，并且可以是嵌合寡核苷酸。 还提供了使用本发明的寡核苷酸抑制人raf表达的方法。 本发明还包括使用本发明的寡核苷酸检测raf基因的存在的方法，包括用于特异性检测活化的截短的raf的方法。 还提供了抑制细胞过度增殖的方法和使用本发明的寡核苷酸处理由异常raf表达引起的病症的方法。