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    Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws
    5.
    发明授权
    Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws 有权
    用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置

    公开(公告)号：US08916186B2

    公开(公告)日：2014-12-23

    申请号：US12605122

    申请日：2009-10-23

    申请人： Hassan Serhan ,  Michael J. O'Neil

    发明人： Hassan Serhan ,  Michael J. O'Neil

    IPC分类号： A61P19/08 ,  A61K38/18 ,  A61K38/02 ,  A61F2/28 ,  A61F2/44 ,  A61F2/46 ,  A61B17/56 ,  A61K38/30

    CPC分类号： A61K38/30 ,  A61K38/1875

    摘要： A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. The screw has a cannulated internal reservoir that contains a chondrocyte growth-inducing pharmaceutical (such as a growth factor or small molecule) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.

    摘要翻译： 一种校正脊柱畸形的方法，其包括将邻近目标脊柱生长板的药物负载植入物定位，然后将该药物洗脱到生长板上。 优选地，该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 螺杆具有插管的内部储存器，其包含软骨细胞生长诱导药物（例如生长因子或小分子）和至少一个允许药物洗脱到椎体生长板上的开窗。

    Method for manipulating intervertebral tissue
    6.
    发明授权
    Method for manipulating intervertebral tissue 有权
    操纵椎间组织的方法

    公开(公告)号：US08882771B2

    公开(公告)日：2014-11-11

    申请号：US13411706

    申请日：2012-03-05

    申请人： Michael J. O'Neil ,  Ramon A. Ruberte ,  Shawn D. Stad ,  John Riley Hawkins

    发明人： Michael J. O'Neil ,  Ramon A. Ruberte ,  Shawn D. Stad ,  John Riley Hawkins

    IPC分类号： A61B17/16 ,  A61B17/00 ,  A61B19/00

    CPC分类号： A61B17/1671 ,  A61B17/1617 ,  A61B17/1659 ,  A61B34/30 ,  A61B90/39 ,  A61B2017/00261 ,  A61B2017/00411 ,  A61B2017/00535 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/00876

    摘要： A method for manipulating intervertebral tissue in one embodiment includes inserting at least one abrading member for abrading tissue into an area to be cleared, expanding at least one expandable member from a first condition to a second condition, wherein the volume defined by the at least one expandable member in the second condition is greater than the volume defined by the at least one expandable member in the first condition, moving the inserted at least one abrading member from a first position to a second position by the expansion of the at least one expandable member, manipulating the inserted at least one abrading member to loosen tissue, and removing the loosened tissue from the area to be cleared.

    摘要翻译： 在一个实施例中，一种用于操纵椎间组织的方法包括将用于研磨组织的至少一个研磨构件插入要清除的区域中，将至少一个可扩张构件从第一状态扩展到第二状态，其中由至少一个 在第二状态下的可膨胀构件大于在第一状态下由至少一个可膨胀构件限定的体积，通过膨胀至少一个可膨胀构件将插入的至少一个研磨构件从第一位置移动到第二位置 操纵插入的至少一个研磨部件以松开组织，以及从要清除的区域中去除松动的组织。

    Method for Manipulating Intervertebral Tissue
    7.
    发明申请
    Method for Manipulating Intervertebral Tissue 有权
    操纵椎间组织的方法

    公开(公告)号：US20120221006A1

    公开(公告)日：2012-08-30

    申请号：US13411706

    申请日：2012-03-05

    申请人： Michael J. O'Neil ,  Ramon A. Ruberte ,  Shawn D. Stad ,  John Riley Hawkins

    发明人： Michael J. O'Neil ,  Ramon A. Ruberte ,  Shawn D. Stad ,  John Riley Hawkins

    IPC分类号： A61B17/16

    CPC分类号： A61B17/1671 ,  A61B17/1617 ,  A61B17/1659 ,  A61B34/30 ,  A61B90/39 ,  A61B2017/00261 ,  A61B2017/00411 ,  A61B2017/00535 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/00876

    摘要： A method for manipulating intervertebral tissue in one embodiment includes inserting at least one abrading member for abrading tissue into an area to be cleared, expanding at least one expandable member from a first condition to a second condition, wherein the volume defined by the at least one expandable member in the second condition is greater than the volume defined by the at least one expandable member in the first condition, moving the inserted at least one abrading member from a first position to a second position by the expansion of the at least one expandable member, manipulating the inserted at least one abrading member to loosen tissue, and removing the loosened tissue from the area to be cleared.

    摘要翻译： 在一个实施例中，一种用于操纵椎间组织的方法包括将用于研磨组织的至少一个研磨构件插入要清除的区域中，将至少一个可扩张构件从第一状态扩展到第二状态，其中由至少一个 在第二状态下的可膨胀构件大于在第一状态下由至少一个可膨胀构件限定的体积，通过膨胀至少一个可膨胀构件将插入的至少一个研磨构件从第一位置移动到第二位置 操纵插入的至少一个研磨部件以松开组织，以及从要清除的区域中去除松动的组织。

    Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws
    10.
    发明申请
    Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws 有权
    用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置

    公开(公告)号：US20110097374A1

    公开(公告)日：2011-04-28

    申请号：US12605122

    申请日：2009-10-23

    申请人： Hassan Serhan ,  Michael J. O'Neil

    发明人： Hassan Serhan ,  Michael J. O'Neil

    IPC分类号： A61K9/00 ,  A61K38/02 ,  A61K38/16 ,  A61P19/00

    CPC分类号： A61K38/30 ,  A61K38/1875

    摘要： A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. The screw has a cannulated internal reservoir that contains a chondrocyte growth-inducing pharmaceutical (such as a growth factor or small molecule) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.

    摘要翻译： 一种校正脊柱畸形的方法，其包括将邻近目标脊柱生长板的药物负载植入物定位，然后将该药物洗脱到生长板上。 优选地，该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 螺杆具有插管的内部储存器，其包含软骨细胞生长诱导药物（例如生长因子或小分子）和至少一个允许药物洗脱到椎体生长板上的开窗。