公开(公告)号：US06496715B1

公开(公告)日：2002-12-17

申请号：US09718689

申请日：2000-11-22

申请人： Brian B. Lee ,  Michael R. Kane ,  Eric J. Panken ,  James D. Reinke

发明人： Brian B. Lee ,  Michael R. Kane ,  Eric J. Panken ,  James D. Reinke

IPC分类号： A61B504

CPC分类号： A61N1/375

摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.

摘要翻译： 一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。 根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。 一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。 然后可以将该位置和取向用作植入相应装置的位置和取向。

公开(公告)号：US06505067B1

公开(公告)日：2003-01-07

申请号：US09721275

申请日：2000-11-22

申请人： Brian B. Lee ,  Eric J. Panken ,  James D. Reinke

发明人： Brian B. Lee ,  Eric J. Panken ,  James D. Reinke

IPC分类号： A61B50402

CPC分类号： A61B5/04011 ,  A61B5/0402 ,  G06F19/00

摘要： A system and method for obtaining a virtual physiologic voltage signal between a first predetermined point in a second selected point in the body is disclosed. At least three electrodes are used to measure two voltage signals S1 and S2 in a body. In one embodiment, the signal S1 is measured between a first electrode and a common electrode, and the signal S2 is measured between a second electrode and the common electrode. A selected point within the body may be chosen to define a pair of virtual electrodes existing between this selected point and the common electrode. An approximation of the voltage signal S as could be measured between electrodes positioned at these virtual electrode locations may be derived as a function of S1, S2, and &thgr;, wherein &thgr; is the angle between the directional vector U1 for the signal S1 and the directional vector U for the signal S. According to the inventive system and method, the signal value for S is also dependent on the distances between the electrode pairs, on the angle &bgr; between directional vectors U1 and U2, and on the distance between the virtual electrodes. The current invention may be utilized with electrodes that are positioned either externally on the surface of, or implanted within, a body. According to one aspect of the invention, a user may employ a user interface to select the values of &thgr;, &bgr;, and the electrode spacings. Alternatively, ones of these parameters may be predetermined by the system. In another embodiment, the system could derive the signal S over a predetermined range of values for the angle &thgr;. The system may then select the angle of &thgr; resulting in the derived signal S that exhibits a desired waveform morphology.

摘要翻译： 公开了一种用于在身体的第二选定点中的第一预定点之间获得虚拟生理电压信号的系统和方法。 使用至少三个电极来测量身体中的两个电压信号S1和S2。 在一个实施例中，在第一电极和公共电极之间测量信号S1，并且在第二电极和公共电极之间测量信号S2。 可以选择体内的选定点以限定存在于该选定点和公共电极之间的一对虚拟电极。 可以在位于这些虚拟电极位置的电极之间测量的电压信号S的近似作为S1，S2和θ的函数导出，其中θ是信号S1的方向矢量U1与方向 信号S的矢量U根据本发明的系统和方法，S的信号值也取决于在方向矢量U1和U2之间的角度β上的电极对之间的距离，以及虚拟电极之间的距离 。 本发明可以与位于体外表面或植入体内的电极一起使用。 根据本发明的一个方面，用户可以使用用户界面来选择θ，β和电极间距的值。 或者，这些参数中的一个可以由系统预先确定。 在另一个实施例中，系统可以在角度θ的预定值范围内导出信号S. 然后，系统可以选择θ的角度，导致出现所需波形形态的导出信号S.

公开(公告)号：US07634310B2

公开(公告)日：2009-12-15

申请号：US11554275

申请日：2006-10-30

申请人： Brian B. Lee ,  Eric J. Panken

发明人： Brian B. Lee ,  Eric J. Panken

IPC分类号： A61B5/024

CPC分类号： A61B5/046 ,  A61B5/02405 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/395

摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.

摘要翻译： 用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。 从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。 响应于所计算的差异，在第一时间间隔之后检测心房心律失常。 响应于心房心律失常检测触发心脏信号的存储。

公开(公告)号：US07912537B2

公开(公告)日：2011-03-22

申请号：US11380435

申请日：2006-04-27

申请人： Brian B. Lee ,  Eric J. Panken ,  Can Cinbis ,  Gerard J. Hill ,  John J. Grevious

发明人： Brian B. Lee ,  Eric J. Panken ,  Can Cinbis ,  Gerard J. Hill ,  John J. Grevious

IPC分类号： A61N1/06

CPC分类号： A61N1/37288 ,  A61N1/3611 ,  A61N1/36135 ,  A61N1/36585 ,  Y10S128/903

摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.

摘要翻译： 生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。 可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

公开(公告)号：US20080081958A1

公开(公告)日：2008-04-03

申请号：US11789438

申请日：2007-04-24

申请人： Timothy J. Denison ,  Brian B. Lee ,  Keith A. Miesel ,  Eric J. Panken

发明人： Timothy J. Denison ,  Brian B. Lee ,  Keith A. Miesel ,  Eric J. Panken

IPC分类号： A61B5/00

CPC分类号： A61N1/3706 ,  A61B2560/0276 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/3702

摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.

摘要翻译： 当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。 事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。 传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。 激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。 或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。 在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

公开(公告)号：US20080188764A1

公开(公告)日：2008-08-07

申请号：US11554275

申请日：2006-10-30

申请人： Brian B. Lee ,  Eric J. Panken

发明人： Brian B. Lee ,  Eric J. Panken

IPC分类号： A61B5/04

CPC分类号： A61B5/046 ,  A61B5/02405 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/395

摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.

摘要翻译： 用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。 从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。 响应于所计算的差异，在第一时间间隔之后检测心房心律失常。 响应于心房心律失常检测触发心脏信号的存储。

公开(公告)号：US20110166464A1

公开(公告)日：2011-07-07

申请号：US13048951

申请日：2011-03-16

申请人： Brian B. Lee ,  Eric J. Panken ,  Can Cinbis ,  Gerard J. Hill ,  John J. Grevious

发明人： Brian B. Lee ,  Eric J. Panken ,  Can Cinbis ,  Gerard J. Hill ,  John J. Grevious

IPC分类号： A61B5/0402 ,  A61B5/0476 ,  A61N1/36

CPC分类号： A61N1/37288 ,  A61N1/3611 ,  A61N1/36135 ,  A61N1/36585 ,  Y10S128/903

摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.

摘要翻译： 生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。 可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

公开(公告)号：US07016721B2

公开(公告)日：2006-03-21

申请号：US09975621

申请日：2001-10-10

申请人： Brian B. Lee ,  Michael R. Kane

发明人： Brian B. Lee ,  Michael R. Kane

IPC分类号： A61B5/0432

CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7285 ,  A61N1/3718

摘要： Triggers and noise should be available as information in recorded electrograms in memories of implantable medical devices. Particularly where the recording of electrogram data is done in the far field, there will be considerable noise and the interpretation of ECG's reproduced from such recorded data will benefit from the storing of information regarding contemporaneous noise. By storing contemporaneous trigger data and noise data directly in the ECG data, recordings of the ECG data become more useful for physician use when played back through an external display system with minimal loss of ECG data, since out of range values are employed for the noise and trigger information and this non-ECG data is limited in size to no longer than individual point values of the ECG signal.

公开(公告)号：US06347245B1

公开(公告)日：2002-02-12

申请号：US09353277

申请日：1999-07-14

申请人： Brian B. Lee ,  Michael R. Kane

发明人： Brian B. Lee ,  Michael R. Kane

IPC分类号： A61B50432

CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7285 ,  A61N1/3718

摘要： A system for recording trigger events and noise in conjunction with the recording of physiological signals is provided for use in an implantable medical device. In one embodiment, recorded trigger and noise data is provided for display to a physician along with reconstructed ECG data to facilitate interpretation of the ECG signal. In one embodiment, digitized ECG samples that are outside of a predetermined range are discarded during the sampling process so that one or more ranges of encoded values are available for use in encoding noise and trigger information. This non-physiologic data may be limited in size to individual point values of the ECG signal.

摘要翻译： 提供了用于记录触发事件和噪声以及生理信号记录的系统，用于可植入医疗装置。 在一个实施例中，记录的触发和噪声数据被提供用于与重建的ECG数据一起显示给医师以便于ECG信号的解读。 在一个实施例中，在采样过程中丢弃在预定范围之外的数字化ECG样本，使得编码值的一个或多个范围可用于编码噪声和触发信息。 该非生理数据的大小可能受到ECG信号的各个点值的限制。

公开(公告)号：US06236882B1

公开(公告)日：2001-05-22

申请号：US09353167

申请日：1999-07-14

申请人： Brian B. Lee ,  Michael R. Kane ,  Gregg Turi

发明人： Brian B. Lee ,  Michael R. Kane ,  Gregg Turi

IPC分类号： A61B50402

CPC分类号： A61B5/0402 ,  A61B5/0432 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7232

摘要： An implantable medical device which preferably has a segmented looping memory for storing triggered physiologic events also has autotriggers to record the ECGs and any other relevant physiologic signals occurring during triggering events. The problem is that in the far field R-wave sensing is difficult because of noise. Denial and extensible accommodation periods are introduced into the R-wave sensing registration for triggering data storage. If the event is sensed during an accommodation period the sense will not add an R-wave sense to the trigger's count of R-waves. It may cause resetting of the trigger count in some circumstnaces. Typical triggering events may include arrhythmia's and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger may be included. Auto triggers and manually set triggers may be of different sizes. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.

摘要翻译： 优选地具有用于存储触发的生理事件的分段循环存储器的可植入医疗装置还具有记录ECG的自动触发器以及在触发事件期间发生的任何其它相关生理信号。 问题在于，在远场R波传感由于噪声困难。 拒绝和可延伸的住宿期被引入到R波感测注册中以触发数据存储。 如果在住宿期间感测到事件，感觉不会在触发器的R波数量上增加R波感。 在某些情况下可能会导致触发计数的重置。 典型的触发事件可能包括心律失常和晕厥事件。 优选地，该装置可以在没有微处理器的情况下工作。 可以包括外部设备或其他患者激活的手动触发器。 自动触发器和手动设置触发器可能具有不同的大小。 电极间距可能很重要。 可以向设备提供附加的传感器。 与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。