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    Nucleotide sequences coding for the pknB gene
    3.
    发明申请
    Nucleotide sequences coding for the pknB gene 有权
    编码pknB基因的核苷酸序列

    公开(公告)号：US20050130277A1

    公开(公告)日：2005-06-16

    申请号：US10940606

    申请日：2004-09-15

    申请人： Brigitte Bathe ,  Stephan Hans ,  Mike Farwick ,  Thomas Hermann

    发明人： Brigitte Bathe ,  Stephan Hans ,  Mike Farwick ,  Thomas Hermann

    IPC分类号： C12N9/12 ,  C12P13/04 ,  C07H21/04 ,  C12N1/21 ,  C12N9/10 ,  C12N9/42 ,  C12N15/74

    CPC分类号： C12N9/1205 ,  C12P13/04 ,  C12Y207/01037

    摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

    摘要翻译： 一种分离的多核苷酸，其含有选自以下的多核苷酸序列：（a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％的多核苷酸，（b） 编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，（c）与（a）或（b）的多核苷酸互补的多核苷酸和（ d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用其中至少pknB基因被扩增的棒状杆菌制备L-氨基酸的发酵方法 以及使用含有本发明序列的多核苷酸作为杂交探针。

    Alleles of the mqo gene from coryneform bacteria
    8.
    发明授权
    Alleles of the mqo gene from coryneform bacteria 有权
    来自棒状细菌的mqo基因的等位基因

    公开(公告)号：US07214526B2

    公开(公告)日：2007-05-08

    申请号：US11333718

    申请日：2006-01-18

    申请人： Brigitte Bathe ,  Stephan Hans ,  Natalie Schischka ,  Georg Thierbach

    发明人： Brigitte Bathe ,  Stephan Hans ,  Natalie Schischka ,  Georg Thierbach

    IPC分类号： C07H21/04 ,  C12P13/22 ,  C12P13/04 ,  C12N1/21

    CPC分类号： C12P13/04 ,  C12N9/0006

    摘要： The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.

    摘要翻译： 本发明涉及棒状细菌mqo基因的突变体和等位基因，其编码苹果酸醌氧化还原酶，其在氨基酸序列中含有111位的L-丝氨酸或氨基酸序列的相当位置的任何氨基酸，以及用于发酵制备氨基酸的方法 酸，优选L-赖氨酸，L-色氨酸和L-脯氨酸，使用包含这些等位基因的细菌。