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公开(公告)号：US20180362508A1
公开(公告)日：2018-12-20
申请号：US16061365
申请日：2016-12-15
发明人： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay
IPC分类号： C07D403/04 , C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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公开(公告)号：US10590113B2
公开(公告)日：2020-03-17
申请号：US16122975
申请日：2018-09-06
发明人： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC分类号： A61K31/505 , C07D403/06 , C07D401/06 , C07D403/14 , C07D239/557 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20190256570A1
公开(公告)日：2019-08-22
申请号：US16287342
申请日：2019-02-27
发明人： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
摘要： The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US20180222960A1
公开(公告)日：2018-08-09
申请号：US15891492
申请日：2018-02-08
发明人： Gene M. DUBOWCHIK , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
摘要： The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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5.发明授权公开(公告)号：US12097242B2
公开(公告)日：2024-09-24
申请号：US17721569
申请日：2022-04-15
发明人： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
IPC分类号： A61K38/22 , A61K38/18 , C07K1/107 , C07K14/64 , A61K38/00 , A61K45/06 , A61K47/64 , A61P9/00
CPC分类号： A61K38/18 , A61K38/2221 , C07K1/1077 , C07K14/64 , A61K38/00 , A61K45/06 , A61K47/64 , A61P9/00
摘要： The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US11364281B2
公开(公告)日：2022-06-21
申请号：US17198939
申请日：2021-03-11
发明人： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
IPC分类号： A61K38/22 , A61K38/18 , C07K14/64 , C07K1/107 , A61K38/00 , A61K47/64 , A61P9/00 , A61K45/06
摘要： The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US10669261B2
公开(公告)日：2020-06-02
申请号：US16061365
申请日：2016-12-15
发明人： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay
IPC分类号： A61K31/506 , A61K31/513 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/00
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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公开(公告)号：US10392347B2
公开(公告)日：2019-08-27
申请号：US15767364
申请日：2016-10-13
发明人： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jiang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC分类号： C07D213/82 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/107 , C07D498/10 , C07D401/12 , C07D471/10
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180297954A1
公开(公告)日：2018-10-18
申请号：US15767364
申请日：2016-10-13
发明人： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D413/14 , C07D401/06 , C07D405/14 , C07D417/14 , C07D417/12 , C07D498/10 , C07D413/12 , C07D491/107 , C07D471/10
CPC分类号： C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/10
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180273518A1
公开(公告)日：2018-09-27
申请号：US15990855
申请日：2018-05-29
发明人： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC分类号： C07D413/04 , C07D417/14 , C07D498/04 , C07D401/04 , C07D413/14
CPC分类号： C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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