公开(公告)号：US20060169891A1

公开(公告)日：2006-08-03

申请号：US11315788

申请日：2005-12-22

申请人： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

发明人： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/067 ,  H01J49/063

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20060151692A1

公开(公告)日：2006-07-13

申请号：US11032376

申请日：2005-01-10

申请人： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

发明人： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/04 ,  H01J49/062

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20070057178A1

公开(公告)日：2007-03-15

申请号：US11222971

申请日：2005-09-12

申请人： Igor Chernushevich ,  Alexandre Loboda ,  Bruce Thomson ,  Andrew Krutchinsky

发明人： Igor Chernushevich ,  Alexandre Loboda ,  Bruce Thomson ,  Andrew Krutchinsky

IPC分类号： H01J49/06

CPC分类号： H01J49/063 ,  H01J49/107

摘要： A multi-device interface for use in mass spectrometry for interfacing one or more ion sources to one or more downstream devices. The multi-device interface comprises three or more multipole rod sets configured as either an input rod set or an output rod set depending on potentials applied to the multipole rod sets. The multipole rod sets configured as an input rod set are connectable to the one or more ion sources for receiving generated ions therefrom and sending the ions to at least one multipole rod set configured as an output multipole rod set. The output multipole rod sets are connectable to a downstream device for sending the generated ions thereto. At least two of the multipole rod sets are configured as input rod sets or at least two of the multipole rod sets are configured as output rod sets.

摘要翻译： 用于质谱法的多器件界面，用于将一个或多个离子源连接到一个或多个下游装置。 多器件接口包括三个或更多个多极杆组，其被配置为根据施加到多极杆组的电位的输入杆组或输出杆组。 配置为输入杆组的多极棒组可连接到一个或多个离子源，用于从其接收生成的离子，并将离子发送到被配置为输出多极棒组的至少一个多极棒组。 输出多极杆组可连接到用于将产生的离子发送到其的下游装置。 多极杆组中的至少两个被配置为输入杆组，或者至少两个多极杆组被配置为输出杆组。

公开(公告)号：US20050056778A1

公开(公告)日：2005-03-17

申请号：US10643092

申请日：2003-08-19

申请人： Bruce Thomson ,  Alexandre Loboda

发明人： Bruce Thomson ,  Alexandre Loboda

IPC分类号： G01N27/62 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

CPC分类号： H01J49/025 ,  H01J49/423 ,  H01J49/4255

摘要： A mass analyzer for use in a mass spectrometry system comprises an elongate rod set. The rod set has first and second ends and an inscribed circle within the rod set. The radius of the rod set varies from one end of the rod set to the other, so that ions of different mass to charge ratios will become unstable at different locations along the rod set. This characteristic can then be used to cause ejection of ions at different locations along the rod set, in a mass dependent manner. Detectors placed linearly along the rod set can then be used to detect ions and determine the mass of the ions from their ejection locations.

摘要翻译： 用于质谱系统的质量分析器包括细长杆组。 杆组具有第一和第二端以及杆组内的内接圆。 杆组的半径从杆组的一端变为另一端，使得不同质荷比的离子在沿着杆组的不同位置处将变得不稳定。 然后，该特性可以用于以质量依赖的方式沿着杆组在不同位置喷射离子。 然后可以使用沿着杆组线性放置的探测器来检测离子并从其喷射位置确定离子的质量。

公开(公告)号：US20100237236A1

公开(公告)日：2010-09-23

申请号：US12408026

申请日：2009-03-20

申请人： Bruce Thomson ,  Bruce Collings

发明人： Bruce Thomson ,  Bruce Collings

IPC分类号： B01D59/44

CPC分类号： H01J49/0045 ,  H01J49/4225 ,  H01J49/427

摘要： A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.

摘要翻译： 在串联质谱仪中处理多种前体离子的方法包括用离子源生成多个前体离子。 多个前体离子中的至少一些被捕获在离子阱中。 感兴趣的至少两个前体离子与多个前体离子与已滤波的噪声场分离。 感兴趣的前体离子顺序地朝向碰撞池排出。 感兴趣的顺序排出的前体离子在碰撞池中碎裂。 然后用质谱仪测定碎片离子的质荷比谱。

公开(公告)号：US08115165B2

公开(公告)日：2012-02-14

申请号：US12788391

申请日：2010-05-27

申请人： Bruce Thomson

发明人： Bruce Thomson

IPC分类号： H01J49/06 ,  H01J49/26

CPC分类号： H01J49/004 ,  H01J49/4245

摘要： A mass spectrometer and method for performing high resolution mass spectrometry are provided, the mass spectrometer comprising an electrostatic trap and mass analyzer. The electrostatic trap comprises entrance and exit ends, entrance and exit end ion mirrors, a central field-free region, and a longitudinal axis. The mass analyzer receives ions from the exit end. Ions are admitted into the electrostatic trap via the entrance end, trapping ions in the electrostatic trap, the ions oscillating between the entrance and exit end ion mirrors along the axis. The electrostatic trap waits for the ions to separate into bunches different m/z values via the oscillating, and then excites a given bunch of ions of a given m/z value along the axis until at least a portion of the given bunch overcomes a barrier field at the exit end ion mirror, exiting the electrostatic trap for analysis, leaving behind remaining ions.

摘要翻译： 提供了用于进行高分辨率质谱的质谱仪和方法，该质谱仪包括静电捕集器和质量分析器。 静电捕获器包括入口和出口端，入口和出口端离子反射镜，中心无场区域和纵向轴线。 质量分析仪从出口端接收离子。 离子通过入口端进入静电捕获器，捕获静电捕获器中的离子，离子在入射和离开端离子反射镜之间沿轴线振荡。 静电捕获器等待离子通过振荡分离成不同m / z值的束，然后沿给定的m / z值激发给定的一束离子，直到给定束的至少一部分克服了屏障 在出口端离子反射镜处，离开静电阱进行分析，留下剩余的离子。

公开(公告)号：US20050098719A1

公开(公告)日：2005-05-12

申请号：US10433473

申请日：2001-12-14

申请人： Bruce Thomson

发明人： Bruce Thomson

IPC分类号： H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/4225 ,  H01J49/0081 ,  H01J49/40

摘要： A method and apparatus are provided for effecting multiple mass selection or analysis steps. Fundamentally, the technique is based on moving ions in different directions through separate components of a mass spectrometer apparatus. To effect different steps, a precursor ion is selected in a first mass selector, and then passed into a collision cell, to effect fragmentation or reaction with a gas, to generate fragment or product ions. The generated product ions are then passed back into the first mass selector, and preferably back into an upstream ion trap. The product ions then pass through the first mass selector again, to select a desired product ion, for further fragmentation and analysis. These steps can be repeated a number of times. A final mass analysis step can be effected in either a time-of-flight section or other mass analyzer. The invention enables conventional triple quadrupole mass spectrometers and QqTOF mass spectrometers to effect multiple MS steps.

摘要翻译： 提供了一种实现多个质量选择或分析步骤的方法和装置。 基本上，该技术基于通过质谱仪装置的分开的部件沿不同方向移动离子。 为了实现不同的步骤，在第一质量选择器中选择前体离子，然后进入碰撞池，以使其与气体发生碎裂或反应，产生碎片或产物离子。 产生的产物离子然后被传回第一质量选择器，并且优选地返回到上游离子阱。 然后，产物离子再次通过第一质量选择器，以选择所需的产物离子，用于进一步的碎裂和分析。 这些步骤可以重复多次。 最后的质量分析步骤可以在飞行时间段或其他质量分析仪中进行。 本发明使传统的三重四极杆质谱仪和QqTOF质谱仪能够实现多个MS步骤。

公开(公告)号：US08557119B1

公开(公告)日：2013-10-15

申请号：US12880359

申请日：2010-09-13

申请人： Kerry Howe ,  Joshua Goldman ,  Bruce Thomson

发明人： Kerry Howe ,  Joshua Goldman ,  Bruce Thomson

IPC分类号： B01D61/58 ,  B01D61/02 ,  B01D15/04 ,  B01D59/30

CPC分类号： B01D61/04 ,  B01D61/025 ,  B01D2311/04 ,  B01D2311/2623 ,  B01D2317/022 ,  C02F1/42 ,  C02F1/441 ,  C02F1/4693 ,  C02F9/00 ,  C02F2001/422 ,  C02F2001/425 ,  C02F2103/08 ,  Y02A20/131 ,  Y02A20/134

摘要： A novel method for improving water recovery from desalination systems by the removal of cations and/or anions using ion exchange (IX) technology. The system described herein is particularly useful for water recovery in brackish ecosystems and is unique in that important features include recycling, regeneration, and recovery of key components, thereby reducing costs and waste products.

摘要翻译： 一种通过使用离子交换（IX）技术去除阳离子和/或阴离子来改善脱盐系统的水回收的新方法。 本文描述的系统特别适用于微咸水生态系统中的水回收，并且是独特的，因为重要特征包括关键组分的回收，再生和回收，从而降低成本和废物。

公开(公告)号：US20090134322A1

公开(公告)日：2009-05-28

申请号：US12275597

申请日：2008-11-21

申请人： Bruce Thomson

发明人： Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/004 ,  G01N27/624

摘要： An apparatus and method of analyzing ions is described in which a Differential Mobility Analyzer (DMA) is combined with an analysis device. The DMS can be operated in first and second modes of operation to produce a plurality of ions that are sampled and analyzed by the analysis device. In the first mode of operation the DMA is configured to enable ion mobility separation and the analysis device samples and analyzes ions having ion mobility in a certain range of ion mobility and in the second mode of operation the DMA is configured to disable ion mobility separation and the analysis device samples and analyzes ions without discrimination based on ion mobility.

摘要翻译： 描述了分析离子的装置和方法，其中差分移动分析器（DMA）与分析装置组合。 DMS可以在第一和第二操作模式下操作，以产生由分析装置采样和分析的多个离子。 在第一操作模式中，DMA被配置为启用离子迁移率分离，并且分析装置对在离子迁移率的一定范围内具有离子迁移率的离子进行采样和分析，并且在第二操作模式中，DMA被配置为禁用离子迁移率分离， 分析装置基于离子迁移率对不分离的离子进行样品和分析。

公开(公告)号：US07145133B2

公开(公告)日：2006-12-05

申请号：US10433473

申请日：2001-12-14

申请人： Bruce Thomson

发明人： Bruce Thomson

IPC分类号： H01J49/26

CPC分类号： H01J49/4225 ,  H01J49/0081 ,  H01J49/40

摘要： A method and apparatus are provided for effecting multiple mass selection or analysis steps. Fundamentally, the technique is based on moving ions in different directions through separate components of a mass spectrometer apparatus. To effect different steps, a precursor ion is selected in a first mass selector, and then passed into a collision cell, to effect fragmentation or reaction with a gas, to generate fragment or product ions. The generated product ions are then passed back into the first mass selector, and preferably back into an upstream ion trap. The product ions then pass through the first mass selector again, to select a desired product ion, for further fragmentation and analysis. These steps can be repeated a number of times. A final mass analysis step can be effected in either a time-of-flight section or other mass analyzer. The invention enables conventional triple quadrupole mass spectrometers and QqTOF mass spectrometers to effect multiple MS steps.

摘要翻译： 提供了一种实现多个质量选择或分析步骤的方法和装置。 基本上，该技术基于通过质谱仪装置的分开的部件沿不同方向移动离子。 为了实现不同的步骤，在第一质量选择器中选择前体离子，然后进入碰撞池，以使其与气体发生碎裂或反应，产生碎片或产物离子。 产生的产物离子然后被传回第一质量选择器，并且优选地返回到上游离子阱。 然后，产物离子再次通过第一质量选择器，以选择所需的产物离子，用于进一步的碎裂和分析。 这些步骤可以重复多次。 最后的质量分析步骤可以在飞行时间段或其他质量分析仪中进行。 本发明使传统的三重四极杆质谱仪和QqTOF质谱仪能够实现多个MS步骤。