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36 条记录 (耗时 0.042 秒)

    METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS
    4.
    发明申请
    METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS 审中-公开
    用于治疗疼痛和瘙痒的方法，组合物和用具

    公开(公告)号：US20100099772A1

    公开(公告)日：2010-04-22

    申请号：US12515429

    申请日：2007-11-19

    申请人： Bruce P. Bean ,  Clifford J. Woolf

    发明人： Bruce P. Bean ,  Clifford J. Woolf

    IPC分类号： A61K31/16 ,  A61P25/00

    CPC分类号： A61K31/167 ,  A61K9/0014 ,  A61K31/085 ,  A61K31/14 ,  A61K31/165 ,  A61K45/06 ,  A61P17/04 ,  A61K2300/00

    摘要： The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

    摘要翻译： 本发明的特征在于通过使细胞与（i）激活存在于伤害感受器和/或抗真菌剂上的通道形成受体的第一化合物接触来抑制细胞中的一个或多个电压门控离子通道的方法; 和（ii）当施加到通道的内表面时抑制一个或多个电压门控离子通道的第二化合物，但是当施加到通道的外表面时基本上不抑制所述通道，其中第二化合物能够 当受体被激活时，通过通道形成受体进入伤害感受器或瘙痒感受器。 本发明还具有季胺衍生物或化合物的其它永久或瞬时带电的衍生物，其在施加到通道的内表面时抑制一个或多个电压门控离子通道，但是当施加到外部表面时基本上不抑制所述通道 的渠道。

    METHODS AND COMPOSITIONS TO REGULATE IRON METABOLISM
    6.
    发明申请
    METHODS AND COMPOSITIONS TO REGULATE IRON METABOLISM 有权
    调节铁代谢的方法和组成

    公开(公告)号：US20120258105A1

    公开(公告)日：2012-10-11

    申请号：US13407502

    申请日：2012-02-28

    申请人： Herbert Y. Lin ,  Jodie Babitt ,  Raymond T. Chung ,  Tarek A. Samad ,  Alan L. Schneyer ,  Clifford J. Woolf

    发明人： Herbert Y. Lin ,  Jodie Babitt ,  Raymond T. Chung ,  Tarek A. Samad ,  Alan L. Schneyer ,  Clifford J. Woolf

    IPC分类号： A61K39/395 ,  A61P3/00 ,  C07K19/00

    CPC分类号： C07K16/2863 ,  A61K38/1709 ,  A61K39/39541 ,  A61K47/64 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/22 ,  C07K16/28 ,  C07K2317/76

    摘要： The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

    摘要翻译： 本发明提供了用于调节哺乳动物铁代谢的新系统和策略。 特别地，使用TGF-β的激动剂和拮抗剂的方法 描述了调节铁代谢的关键调节剂的铁调素的表达或活性的超家族成员。 本发明的方法可用于治疗与铁超负荷相关的疾病，例如青少年血色素沉着症和成人血色素沉着症，以及治疗与铁缺乏有关的疾病，如慢性疾病贫血和肾脏末期的EPO耐药性贫血 疾病。 本发明还涉及用于开发用于治疗铁代谢紊乱的新型药物和疗法的筛选工具和方法。

    METHODS AND COMPOSITION TO REGULATE IRON METABOLISM
    7.
    发明申请
    METHODS AND COMPOSITION TO REGULATE IRON METABOLISM 有权
    调节铁代谢的方法和组成

    公开(公告)号：US20120064076A1

    公开(公告)日：2012-03-15

    申请号：US13171438

    申请日：2011-06-28

    申请人： Herbert Y. Lin ,  Jodie Babitt ,  Raymond T. Chung ,  Tarek A. Samad ,  Alan L. Schneyer ,  Clifford J. Woolf

    发明人： Herbert Y. Lin ,  Jodie Babitt ,  Raymond T. Chung ,  Tarek A. Samad ,  Alan L. Schneyer ,  Clifford J. Woolf

    IPC分类号： A61K39/395 ,  C07K19/00 ,  A61P7/06

    CPC分类号： C07K16/2863 ,  A61K38/1709 ,  A61K39/39541 ,  A61K47/64 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/22 ,  C07K16/28 ,  C07K2317/76

    摘要： The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

    摘要翻译： 本发明提供了用于调节哺乳动物铁代谢的新系统和策略。 特别是使用TGF-β的激动剂和拮抗剂的方法; 描述了调节铁代谢的关键调节剂的铁调素的表达或活性的超家族成员。 本发明的方法可用于治疗与铁超负荷相关的疾病，例如青少年血色素沉着症和成人血色素沉着症，以及治疗与铁缺乏有关的疾病，如慢性疾病贫血和肾脏末期的EPO耐药性贫血 疾病。 本发明还涉及用于开发用于治疗铁代谢紊乱的新型药物和疗法的筛选工具和方法。