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    NOVEL MULTIMODULAR ASSEMBLY USEFUL FOR INTRACELLULAR DELIVERY
    1.
    发明申请
    NOVEL MULTIMODULAR ASSEMBLY USEFUL FOR INTRACELLULAR DELIVERY 有权
    新颖的多功能组件可用于细胞内输送

    公开(公告)号：US20120058139A1

    公开(公告)日：2012-03-08

    申请号：US13062339

    申请日：2009-09-02

    申请人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    发明人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    IPC分类号： A61K39/385 ,  A61P43/00 ,  A61P37/04 ,  C12N15/63 ,  A61K48/00

    CPC分类号： A61K48/0041 ,  A61K9/1272 ,  A61K9/1273 ,  A61K47/6911

    摘要： A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.

    摘要翻译： 一种用于细胞内递送的稳定的多模式组合物，其包含至少一种阳离子转染剂和至少一个带负电荷的大分子的复合物，其中所述络合物具有约0至约4的理论电荷比，以及有效量的至少一种 作为相对于配合物的空间胶体稳定剂的两亲嵌段共聚物，嵌段共聚物具有亲水和疏水嵌段，其中至少一个亲水嵌段与至少一个靶向配体缀合。

    Multimodular assembly useful for intracellular delivery
    2.
    发明授权
    Multimodular assembly useful for intracellular delivery 有权
    用于细胞内递送的多模式组装

    公开(公告)号：US08790664B2

    公开(公告)日：2014-07-29

    申请号：US13062339

    申请日：2009-09-02

    申请人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    发明人： Bruno Pitard ,  Charles Tellier ,  Corinne Miral ,  Emilie Letrou-Bonneval

    IPC分类号： A61K48/00

    CPC分类号： A61K48/0041 ,  A61K9/1272 ,  A61K9/1273 ,  A61K47/6911

    摘要： A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.

    摘要翻译： 一种用于细胞内递送的稳定的多模式组合物，其包含至少一种阳离子转染剂和至少一个带负电荷的大分子的复合物，其中所述络合物具有约0至约4的理论电荷比，以及有效量的至少一种 作为相对于配合物的空间胶体稳定剂的两亲嵌段共聚物，嵌段共聚物具有亲水和疏水嵌段，其中至少一个亲水嵌段与至少一个靶向配体缀合。