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公开(公告)号：US11980616B2
公开(公告)日：2024-05-14
申请号：US17114379
申请日：2020-12-07
申请人： Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research
发明人： Remi-Martin Laberge , Judith Campisi , Marco Demaria , Nathaniel David , James L. Kirkland , Tamar Tchkonia , Yi Zhu
IPC分类号： A61K31/496 , A61K9/00 , A61K31/404 , A61K31/4178 , A61K31/428 , A61K31/4375 , A61K31/495 , A61K31/5377 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/68 , A61P9/10 , A61P11/00 , A61P25/28 , A61P27/02 , C12N5/00 , C12N15/113 , C12Q1/48
CPC分类号： A61K31/496 , A61K9/0048 , A61K9/0073 , A61K31/404 , A61K31/4178 , A61K31/428 , A61K31/4375 , A61K31/495 , A61K31/5377 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/6807 , A61P9/10 , A61P11/00 , A61P25/28 , A61P27/02 , C12N5/0081 , C12N15/113 , C12N2320/30 , C12N2501/999 , C12N2503/02 , C12Q1/485
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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公开(公告)号：US20210030752A1
公开(公告)日：2021-02-04
申请号：US17066256
申请日：2020-10-08
申请人： Buck Institute for Research on Aging , Mayo Foundation for Medical Education and Research , Unity Biotechnology, Inc.
发明人： Remi-Martin Laberge , Judith Campisi , Marco Demaria , Nathaniel David , Darren J. Baker , Jan M.A. van Deursen , Albert Davalos
IPC分类号： A61K31/496 , A61P11/00 , A61P9/10 , A61P27/02 , A61K31/428 , A61K31/495 , A61K31/5377 , C12N15/113 , A61K31/404 , A61K31/4375 , A61K45/06 , A61K31/4178 , A61K31/728 , C12N5/00 , A61K47/36 , A61K9/00
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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公开(公告)号：US20200030323A1
公开(公告)日：2020-01-30
申请号：US16584638
申请日：2019-09-26
申请人： Buck Institute for Research on Aging , Mayo Foundation for Medical Education and Research , Unity Biotechnology, Inc.
发明人： Remi-Martin Laberge , Judith Campisi , Marco Demaria , Nathaniel David , James L. Kirkland , Tamar Tchkonia , Yi Zhu , Darren J. Baker , Jan M.A. van Deursen
IPC分类号： A61K31/496 , A61P11/00 , A61P9/10 , A61P27/02 , A61K31/428 , A61K31/495 , A61K31/5377 , A61K31/404 , A61K31/4375 , A61K45/06 , A61K31/4178 , A61K31/728 , C12N5/00 , A61K47/36 , A61K9/00
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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公开(公告)号：US10478433B2
公开(公告)日：2019-11-19
申请号：US16007880
申请日：2018-06-13
申请人： Unity Biotechnology, Inc. , Buck Institute for Research on Aging , Mayo Foundation for Medical Education and Research
发明人： Remi-Martin Laberge , Judith Campisi , Marco Demaria , Nathaniel David , Darren J. Baker , James L. Kirkland , Tamar Tchkonia , Yi Zhu , Jan M. A. van Deursen , Alain Philippe Vasserot , Bennett G. Childs
IPC分类号： A61K31/496 , A61P27/02 , A61P27/06 , A61K9/00 , A61P11/00 , A61P9/10 , A61K31/428 , A61K31/495 , A61K31/5377 , A61K31/404 , A61K31/4375 , A61K45/06 , A61K31/4178 , A61K31/728 , C12N5/00 , A61K47/36 , C12Q1/48
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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公开(公告)号：US20190201510A1
公开(公告)日：2019-07-04
申请号：US16352465
申请日：2019-03-13
申请人： Unity Biotechnology, Inc. , Kythera Biopharmaceuticals, Inc. , Buck Institute for Research on Aging
CPC分类号： A61K39/0005 , A61K39/39 , A61K2039/70 , C07K14/47 , C07K16/18 , C07K16/28 , C07K2317/56 , C07K2317/64
摘要： Provided herein are immunogenic compositions (vaccines) and methods for immunizing a subject with the immunogenic compositions for inducing an adaptive immune response directed specifically against senescent cells for treatment and prophylaxis of age-related diseases and disorders, and other diseases and disorders associated with or exacerbated by the presence of senescent cells. The immunogenic compositions provided herein comprise at least one or more senescent cell-associated antigens, polynucleotides encoding senescent cell-associated antigens, and recombinant expression vectors comprising the polynucleotides for use in administering to a subject in need thereof.
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6.发明授权公开(公告)号：US10279018B2
公开(公告)日：2019-05-07
申请号：US14649022
申请日：2013-12-03
申请人： UNITY BIOTECHNOLOGY, INC. , KYTHERA BIOPHARMACEUTICALS, INC. , BUCK INSTITUTE FOR RESEARCH ON AGING
摘要： Provided herein are immunogenic compositions (vaccines) and methods for immunizing a subject with the immunogenic compositions for inducing an adaptive immune response directed specifically against senescent cells for treatment and prophylaxis of age-related diseases and disorders, and other diseases and disorders associated with or exacerbated by the presence of senescent cells. The immunogenic compositions provided herein comprise at least one or more senescent cell-associated antigens, polynucleotides encoding senescent cell-associated antigens, and recombinant expression vectors comprising the polynucleotides for use in administering to a subject in need thereof.
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公开(公告)号：US20180139939A1
公开(公告)日：2018-05-24
申请号：US15870172
申请日：2018-01-12
IPC分类号： A01K67/027 , A61K49/00 , C12N15/85
CPC分类号： A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K49/0008 , C12N15/8509 , C12N2015/859 , C12N2830/008
摘要： This disclosure provides non-human animal models for age-related disorders and age-sensitive traits, particularly those caused by senescence-inducing stimuli, wherein the models comprise transgenes selectively expressed by senescent cells. The disclosure further provides methods for identifying therapeutic agents effective for treating or preventing age-related disorders and age-sensitive traits using the animal models, therapeutic agents identified using such methods, pharmaceutical compositions comprising the identified therapeutic agents, and methods of treating or preventing age-related disorders and age-sensitive traits.
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8.发明授权公开(公告)号：US09849128B2
公开(公告)日：2017-12-26
申请号：US15455575
申请日：2017-03-10
申请人： Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research , The John Hopkins University
发明人： Remi-Martin Laberge , Judith Campisi , Albert Davalos , Marco Demaria , Nathaniel David , Alain Philippe Vasserot , James L. Kirkland , Tamar Tchkonia , Yi Zhu , Jennifer Elisseeff , Chaekyu Kim , Okhee Jeon
IPC分类号： A61K31/417 , A61K31/496 , A61K31/728 , A61K31/4178
CPC分类号： A61K31/496 , A61K9/0048 , A61K9/0073 , A61K31/404 , A61K31/4178 , A61K31/428 , A61K31/4375 , A61K31/495 , A61K31/5377 , A61K31/728 , A61K45/06 , A61K47/36 , C12N5/0081 , C12N2501/999 , C12N2503/02
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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9.发明申请公开(公告)号：US20170198253A1
公开(公告)日：2017-07-13
申请号：US15455684
申请日：2017-03-10
申请人： Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research , The John Hopkins University
发明人： Remi-Martin Laberge , Judith Campisi , Albert Davalos , Marco Demaria , Nathaniel David , Alain Philippe Vasserot , Darren J. Baker , Bennett G. Childs , James L. Kirkland , Tamar Tchkonia , Jan M.A. van Deursen , Jennifer Elisseeff , Chaekyu Kim , Okhee Jeon , Allyson K. Palmer
IPC分类号： C12N5/00
CPC分类号： A61K31/496 , A61K9/0048 , A61K9/0073 , A61K31/404 , A61K31/4178 , A61K31/428 , A61K31/4375 , A61K31/495 , A61K31/5377 , A61K31/728 , A61K45/06 , A61K47/36 , A61P11/00 , C12N5/0081 , C12N2501/999 , C12N2503/02
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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10.发明申请公开(公告)号：US20170196858A1
公开(公告)日：2017-07-13
申请号：US15455630
申请日：2017-03-10
申请人： Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research , The John Hopkins University
发明人： Remi-Martin Laberge , Judith Campisi , Albert Davalos , Marco Demaria , Nathaniel David , Alain Philippe Vasserot , Darren J. Baker , Bennett G. Childs , James L. Kirkland , Tamar Tchkonia , Jan M.A. van Deursen , Jennifer Elisseeff , Chaekyu Kim , Okhee Jeon , Allyson K. Palmer
IPC分类号： A61K31/496 , C12N5/00
CPC分类号： A61K31/496 , A61K9/0048 , A61K9/0073 , A61K31/404 , A61K31/4178 , A61K31/428 , A61K31/4375 , A61K31/495 , A61K31/5377 , A61K31/728 , A61K45/06 , A61K47/36 , A61P9/10 , A61P11/00 , A61P27/02 , C12N5/0081 , C12N2501/999 , C12N2503/02 , C12Q1/485
摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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