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公开(公告)号：US10604774B2
公开(公告)日：2020-03-31
申请号：US15799466
申请日：2017-10-31
摘要： Provided herein are processes and microorganisms which utilize both protein hydrolysates and carbohydrates from biomass feedstocks to produce renewable hydrocarbon compositions. Advantages of the disclosed methods may be recognized in fuel blends comprising such hydrocarbon compositions.
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公开(公告)号：US09771602B2
公开(公告)日：2017-09-26
申请号：US14213274
申请日：2014-03-14
摘要： Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products. Host cells provided herein comprise a pyruvate-utilizing pathway and a competitive growth advantage over other microorganisms in solution.
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3.发明申请INCREASED PRODUCTION OF ISOBUTANOL IN YEAST WITH REDUCED MITOCHONDRIAL AMINO ACID BIOSYNTHESIS 审中-公开用减少的氨基酸氨基酸生物合成来增加在日本生产的异丁醇公开(公告)号：US20150368656A1
公开(公告)日：2015-12-24
申请号：US14848792
申请日：2015-09-09
CPC分类号： C12P7/16 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12N15/81 , C12Y203/03013 , C12Y206/01042 , C12Y401/01001 , C12Y403/01019 , Y02E50/10 , Y02P20/52
摘要： Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.
摘要翻译： 描述了酵母线粒体中涉及支链氨基酸生物合成的某些酶活性降低的酵母细胞。 靶酶包括苏氨酸脱氨酶，异丙基苹果酸合酶和任选的支链氨基酸转氨酶。
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4.发明授权公开(公告)号：US09404117B2
公开(公告)日：2016-08-02
申请号：US14848792
申请日：2015-09-09
CPC分类号： C12P7/16 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12N15/81 , C12Y203/03013 , C12Y206/01042 , C12Y401/01001 , C12Y403/01019 , Y02E50/10 , Y02P20/52
摘要： Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.
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公开(公告)号：US20160024534A1
公开(公告)日：2016-01-28
申请号：US14873956
申请日：2015-10-02
摘要： Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe—S cluster for their activity. The yeast strains have reduced activity of an endogenous Fe—S protein. Activities of heterologous fungal or plant 2Fe-2S dihydroxy-acid dehydratases and Fe—S propanediol dehydratase reactivase were increased for increased production of products made using biosynthetic pathways including these enzymes, such as valine, isoleucine, leucine, pantothenic acid (vitamin B5), isobutanol, 2-butanone and 2-butanol.
摘要翻译： 工程化的酵母菌株具有增加Fe-S簇结合活性的异源蛋白质的活性。 酵母菌株内源性Fe-S蛋白的活性降低。 增加异源真菌或植物2Fe-2S二羟基酸脱水酶和Fe-S丙二醇脱水酶再活化酶的活性，以增加使用包括这些酶的生物合成途径（如缬氨酸，异亮氨酸，亮氨酸，泛酸（维生素B5））， 异丁醇，2-丁酮和2-丁醇。
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公开(公告)号：US08969065B2
公开(公告)日：2015-03-03
申请号：US14161619
申请日：2014-01-22
摘要： A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains.
摘要翻译： 通过在细胞质中表达乙酰乳酸合酶，结合丙酮酸脱羧酶活性的降低，在酵母中实现了丙酮酸向乙酰乳酸转化的高通量。 改善乙酰乳酸通量的额外操作是降低丙酮酸脱氢酶活性和降低甘油-3-磷酸脱氢酶活性。 具有乙酰乳酸酯作为上游中间体的化合物的生产受益于所述菌株中丙酸酯向乙酰乳酸的转化率的增加。
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公开(公告)号：US10280438B2
公开(公告)日：2019-05-07
申请号：US15502913
申请日：2015-08-11
摘要： The invention relates to the fields of industrial microbiology and alcohol production including production of yeast products with features suitable for transport, storage, and utilization in fermentation.
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公开(公告)号：US10184139B2
公开(公告)日：2019-01-22
申请号：US15670825
申请日：2017-08-07
摘要： The invention relates to recombinant host cells having at least one integrated polynucleotide encoding a polypeptide that catalyzes a step in a pyruvate-utilizing biosynthetic pathway, e.g., pyruvate to acetolactate conversion. The invention also relates to methods of increasing the biosynthetic production of isobutanol, 2,3-butanediol, 2-butanol or 2-butanone using such host cells.
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公开(公告)号：US20170233771A1
公开(公告)日：2017-08-17
申请号：US15502913
申请日：2015-08-11
CPC分类号： C12P7/16 , C12N1/16 , C12N9/0006 , C12N9/22 , C12N9/2402 , C12N9/88 , C12Y101/01006 , C12Y302/01028 , C12Y402/03123 , Y02E50/10
摘要： The invention relates to the fields of industrial microbiology and alcohol production including production of yeast products with features suitable for transport, storage, and utilization in fermentation
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10.发明申请Increased Production of Isobutanol in Yeast with Reduced Mitochondrial Amino Acid Biosynthesis 审中-公开酵母中减少线粒体氨基酸生物合成增加异丁醇的生产公开(公告)号：US20160304909A1
公开(公告)日：2016-10-20
申请号：US15197877
申请日：2016-06-30
CPC分类号： C12P7/16 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12N15/81 , C12Y203/03013 , C12Y206/01042 , C12Y401/01001 , C12Y403/01019 , Y02E50/10 , Y02P20/52
摘要： Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.
摘要翻译： 描述了酵母线粒体中涉及支链氨基酸生物合成的某些酶活性降低的酵母细胞。 靶酶包括苏氨酸脱氨酶，异丙基苹果酸合酶和任选的支链氨基酸转氨酶。
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