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公开(公告)号：US20050164254A1
公开(公告)日：2005-07-28
申请号：US11010227
申请日：2004-12-09
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
摘要翻译： 提供化合物，组合物和方法用于调节adipophilin的表达。 组合物包含针对编码脂肪蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节脂肪蛋白表达和用于诊断和治疗与亲脂素表达相关的疾病和病症的方法。
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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公开(公告)号：US20060019920A1
公开(公告)日：2006-01-26
申请号：US11179128
申请日：2005-07-11
申请人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
CPC分类号： C12N9/1205 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
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4.发明申请Compositions and their uses directed to cell growth and maintenance proteins 审中-公开组合物及其用于细胞生长和维持蛋白质的用途公开(公告)号：US20050186594A1
公开(公告)日：2005-08-25
申请号：US11015161
申请日：2004-12-17
申请人： C. Bennett , Susan Freier , Nicholas Dean , Ian Popoff , Brett Monia , Donna Ward , Ming-Yi Chiang , Ravi Jain , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Ian Popoff , Brett Monia , Donna Ward , Ming-Yi Chiang , Ravi Jain , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6811 , C12Q1/6883 , C12Q2600/158 , C12Q2600/16 , C12Y207/11001 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of G protein-coupled receptor kinase 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G protein-coupled receptor kinase 6. Methods of using these compounds for modulation of G protein-coupled receptor kinase 6 expression and for treatment of diseases associated with expression of G protein-coupled receptor kinase 6 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节G蛋白偶联受体激酶6的表达。组合物包含靶向编码G蛋白偶联受体激酶6的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物的方法 提供G蛋白偶联受体激酶6表达的调节和用于治疗与G蛋白偶联受体激酶6的表达相关的疾病。
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公开(公告)号：US20050227939A1
公开(公告)日：2005-10-13
申请号：US11036095
申请日：2005-01-14
申请人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21034 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节激肽释放酶6的表达。该组合物包含靶向编码激肽释放酶的核酸的寡核苷酸。6.使用这些化合物调节激肽释放酶6表达并用于诊断和治疗与表达相关的疾病的方法 提供激肽释放酶6。
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公开(公告)号：US20050153925A1
公开(公告)日：2005-07-14
申请号：US11013608
申请日：2004-12-16
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节肝细胞生长因子受体的表达。 组合物包含针对编码肝细胞生长因子受体的核酸的寡核苷酸。 提供了使用这些化合物调节肝细胞生长因子受体表达和用于诊断和治疗与肝细胞生长因子受体表达相关的疾病的方法。
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7.发明申请Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开固醇调节元件结合蛋白-1表达的反义调制公开(公告)号：US20050215504A1
公开(公告)日：2005-09-29
申请号：US11014360
申请日：2004-12-16
申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。
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公开(公告)号：US20050164271A1
公开(公告)日：2005-07-28
申请号：US11039629
申请日：2005-01-20
申请人： Sanjay Bhanot , Kenneth Dobie , Susan Freier , Nicholas Dean , C. Bennett
发明人： Sanjay Bhanot , Kenneth Dobie , Susan Freier , Nicholas Dean , C. Bennett
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/02
CPC分类号： C07H21/04 , A61K38/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for diagnosis and treatment of diseases and conditions associated with expression of glucocorticoid receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节糖皮质激素受体的表达。 组合物包含靶向编码糖皮质激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节糖皮质激素受体表达和诊断和治疗与糖皮质激素受体表达相关的疾病和病症的方法。
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公开(公告)号：US20050227938A1
公开(公告)日：2005-10-13
申请号：US11015193
申请日：2004-12-17
申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。
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10.发明申请公开(公告)号：US20050222073A1
公开(公告)日：2005-10-06
申请号：US11071724
申请日：2005-03-02
申请人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甲状腺激素受体相互作用体6的表达。该组合物包含靶向编码甲状腺激素受体相互作用核酸的反义化合物，特别是反义寡核苷酸。6.使用这些化合物调节甲状腺激素的方法 受体相互作用6表达和用于治疗与甲状腺激素受体相互作用者6的表达相关的疾病。
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