公开(公告)号：US20050153924A1

公开(公告)日：2005-07-14

申请号：US11013543

申请日：2004-12-15

申请人： C. Bennett ,  Brett Monia ,  Susan Murray ,  Madeline Butler ,  Nicholas Dean ,  Rosanne Crooke ,  Mark Graham ,  Hong Zhang ,  Susan Freier ,  Brenda Baker ,  Eric Marcusson ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Andrew Watt

发明人： C. Bennett ,  Brett Monia ,  Susan Murray ,  Madeline Butler ,  Nicholas Dean ,  Rosanne Crooke ,  Mark Graham ,  Hong Zhang ,  Susan Freier ,  Brenda Baker ,  Eric Marcusson ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Andrew Watt

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。

公开(公告)号：US20050227938A1

公开(公告)日：2005-10-13

申请号：US11015193

申请日：2004-12-17

申请人： C. Bennett ,  Brenda Baker ,  Nicholas Dean ,  Brett Monia ,  Susan Freier ,  James Karras ,  Hong Zhang ,  Susan Murray ,  Madeline Butler ,  Erich Koller ,  Thomas Condon ,  William Gaarde ,  Andrew Watt ,  Mark Graham ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Mark Roach

发明人： C. Bennett ,  Brenda Baker ,  Nicholas Dean ,  Brett Monia ,  Susan Freier ,  James Karras ,  Hong Zhang ,  Susan Murray ,  Madeline Butler ,  Erich Koller ,  Thomas Condon ,  William Gaarde ,  Andrew Watt ,  Mark Graham ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Mark Roach

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/335 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。

公开(公告)号：US20060160758A1

公开(公告)日：2006-07-20

申请号：US11039632

申请日：2005-01-20

申请人： C. Bennett ,  Susan Freier ,  Brenda Baker ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Susan Murray ,  Lex Cowsert ,  Madeline Butler ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Ian Popoff ,  Jacqueline Wyatt ,  Andrew Watt

发明人： C. Bennett ,  Susan Freier ,  Brenda Baker ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Susan Murray ,  Lex Cowsert ,  Madeline Butler ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Ian Popoff ,  Jacqueline Wyatt ,  Andrew Watt

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.

公开(公告)号：US20060019920A1

公开(公告)日：2006-01-26

申请号：US11179128

申请日：2005-07-11

申请人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

发明人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N9/1205 ,  Y02P20/582

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

公开(公告)号：US20060154885A1

公开(公告)日：2006-07-13

申请号：US11072846

申请日：2005-03-04

申请人： C. Bennett ,  Brett Monia ,  Nicholas Dean ,  Xiaoxing Xu ,  Sanjay Bhanot ,  Brenda Baker ,  Susan Freier ,  Lex Cowsert ,  Robert McKay ,  Muthiah Manoharan ,  F. Dorr ,  Jon Holmlund ,  Alexander Borchers ,  Vickie Brown-Driver ,  Jacqueline Wyatt ,  Shin Flournoy ,  Elizabeth Ackermann ,  Hong Zhang ,  Andrew Watt ,  Eric Maracusson ,  Scott Cooper ,  Erich Koller ,  Loren Miraglia ,  William Ricketts ,  Kenneth Dobie ,  Tamara Sipes

发明人： C. Bennett ,  Brett Monia ,  Nicholas Dean ,  Xiaoxing Xu ,  Sanjay Bhanot ,  Brenda Baker ,  Susan Freier ,  Lex Cowsert ,  Robert McKay ,  Muthiah Manoharan ,  F. Dorr ,  Jon Holmlund ,  Alexander Borchers ,  Vickie Brown-Driver ,  Jacqueline Wyatt ,  Shin Flournoy ,  Elizabeth Ackermann ,  Hong Zhang ,  Andrew Watt ,  Eric Maracusson ,  Scott Cooper ,  Erich Koller ,  Loren Miraglia ,  William Ricketts ,  Kenneth Dobie ,  Tamara Sipes

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/1138 ,  A61K48/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。

公开(公告)号：US20050215504A1

公开(公告)日：2005-09-29

申请号：US11014360

申请日：2004-12-16

申请人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

发明人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。

公开(公告)号：US06503754B1

公开(公告)日：2003-01-07

申请号：US09657346

申请日：2000-09-07

申请人： Hong Zhang ,  Jacqueline Wyatt

发明人： Hong Zhang ,  Jacqueline Wyatt

IPC分类号： C07H2104

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of BH3 Interacting domain Death agonist. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding BH3 Interacting domain Death agonist. Methods of using these compounds for modulation of BH3 Interacting domain Death agonist expression and for treatment of diseases associated with expression of BH3 Interacting domain Death agonist are provided.

公开(公告)号：US20050101555A1

公开(公告)日：2005-05-12

申请号：US10663451

申请日：2003-09-16

申请人： Hong Zhang ,  Andrew Watt

发明人： Hong Zhang ,  Andrew Watt

IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N15/113 ,  C07H21/04

CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y304/2206 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of caspase 7. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding caspase 7. Methods of using these compounds for modulation of caspase 7 expression and for treatment of diseases associated with expression of caspase 7 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节半胱天冬酶7的表达。组合物包含靶向编码半胱天冬酶7的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节半胱天冬酶7表达和治疗疾病的方法 提供与胱天蛋白酶7的表达相关的。

公开(公告)号：US20240262865A1

公开(公告)日：2024-08-08

申请号：US18099258

申请日：2023-01-19

申请人： Hong Zhang ,  Xinfang Zhao

发明人： Hong Zhang ,  Xinfang Zhao

IPC分类号： C07K7/64 ,  G01N33/58

CPC分类号： C07K7/64 ,  G01N33/582 ,  C07K2319/40

摘要： The present invention relates to the phosphatidylserine (PS) binding compound derivative and the fusion of PS binding compound with an arm compound. The present invention describes the methods of producing and using PS binding compound derivative and the fusion of PS binding compound with an arm compound by providing the functional group to couple with functional group containing fluorophore for multicolor flow cytometry and multiplex imaging; to conjugate with magnetic particle for depleting the PS positive cells; to couple with oligo comprising PCR handle sequence, and unique DNA barcode for PS positive cells and capture sequence for discriminating positive cells from live cells in Single-cell RNA sequencing.

公开(公告)号：US10603077B2

公开(公告)日：2020-03-31

申请号：US12101752

申请日：2008-04-11

申请人： Hong Zhang ,  Dan Sucato

发明人： Hong Zhang ,  Dan Sucato

IPC分类号： A61B17/70 ,  A61F2/44 ,  A61B90/00

摘要： The present invention includes an apparatus, kit and method for providing a bone fixation assembly for attachment to a bone to provide augmented support. The bone fixation assembly includes a screw having a screw head and a threaded shank. A first aperture is positioned about the screw head to receive a first longitudinal member and a first compression member that engages the first aperture to secure the first longitudinal member. The screw head has a second aperture positioned to receive a second longitudinal member and a second compression member that engages the second longitudinal member aperture to secure the second longitudinal member and provide augmented support.