公开(公告)号：US12024509B2

公开(公告)日：2024-07-02

申请号：US16814328

申请日：2020-03-10

Applicant: C4X Discovery Limited

Inventor： Emma Louise Blaney ,  Barrie Phillip Martin ,  Thorsten Nowak ,  Martin John Watson

IPC: C07D471/04 ,  A61K31/4192 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/47 ,  A61P3/04 ,  A61P19/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D471/04 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

公开(公告)号：US20200270247A1

公开(公告)日：2020-08-27

申请号：US16814328

申请日：2020-03-10

Applicant: C4X Discovery Limited

Inventor： Emma Louise Blaney ,  Barrie Phillip Martin ,  Thorsten Nowak ,  Martin John Watson

IPC: C07D471/04 ,  C07D401/14 ,  C07D413/14 ,  C07D213/74 ,  C07D401/12 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07C233/69 ,  C07C233/78 ,  C07D213/63 ,  C07D231/38 ,  C07C275/28 ,  C07C275/40 ,  C07D213/64 ,  C07D403/12

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

公开(公告)号：US20230159511A1

公开(公告)日：2023-05-25

申请号：US17920244

申请日：2021-04-22

Applicant: C4X Discovery Limited

Inventor： Cathy Louise Lucas ,  Emma Louise Blaney ,  Barrie Phillip Martin ,  Thorsten Nowak ,  Nicholas Charles Ray ,  Simon Ross Crumpler ,  Eileen Mary Seward ,  George Hynd

IPC: C07D413/14 ,  C07D401/06 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

CPC classification number: C07D413/14 ,  C07D401/06 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

公开(公告)号：US20170291897A1

公开(公告)日：2017-10-12

申请号：US15508392

申请日：2015-09-03

Applicant: C4X Discovery Limited

Inventor： Emma Louise Blaney ,  Barrie Phillip Martin ,  Thorsten Nowak ,  Martin John Watson

IPC: C07D471/04 ,  C07D213/74 ,  C07D417/12 ,  C07D401/14 ,  C07C233/69 ,  C07D239/34 ,  C07D239/80 ,  C07D235/26 ,  C07D213/64 ,  C07D239/42 ,  C07D239/84 ,  C07D235/30 ,  C07D403/12 ,  C07D413/12 ,  C07C233/78 ,  C07C275/40 ,  C07D413/14 ,  C07D417/14 ,  C07D401/12

CPC classification number: C07D471/04 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.