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公开(公告)号：US20170320823A1
公开(公告)日：2017-11-09
申请号：US15594795
申请日：2017-05-15
IPC分类号： C07D207/333 , C07D233/58 , A61K31/155 , C07C279/14 , C07C229/26 , C07C217/60 , C07C215/40 , C07C215/12 , C07C215/10 , C07C211/51 , C07C211/35 , C07C211/30 , C07C211/27 , C07C211/11 , A61K45/06 , A61K38/26 , A61K31/64 , A61K31/505 , A61K31/4985 , A61K31/4015 , A61K31/40 , C07D295/027 , C07C2601/14
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.
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公开(公告)号：US09656954B2
公开(公告)日：2017-05-23
申请号：US14783336
申请日：2014-07-04
IPC分类号： C07D207/333 , A61K45/06 , C07C211/27 , C07C279/14 , C07C215/20 , C07C229/26 , C07D295/027 , C07D233/58 , C07C215/12 , C07C215/40 , C07C211/35 , C07C211/30 , C07C217/60 , A61K31/155 , A61K31/40 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K31/4015 , C07C211/11 , C07C211/51 , C07C215/10
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.
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公开(公告)号：US10315993B2
公开(公告)日：2019-06-11
申请号：US15962498
申请日：2018-04-25
IPC分类号： C07D207/333 , C07C215/40 , A61K38/26 , C07D295/027 , A61K31/4985 , C07C215/10 , C07C217/60 , C07C211/51 , C07D233/58 , A61K31/4015 , C07C211/11 , C07C215/12 , C07C211/30 , C07C229/26 , A61K31/40 , A61K31/155 , C07C211/27 , A61K31/64 , A61K31/505 , C07C211/35 , A61K45/06 , C07C279/14
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.
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公开(公告)号：US20180305311A1
公开(公告)日：2018-10-25
申请号：US15962498
申请日：2018-04-25
IPC分类号： C07D207/333 , C07C215/40 , A61K38/26 , C07D295/027 , A61K31/4985 , C07C215/10 , C07C217/60 , C07C211/51 , C07D233/58 , A61K31/4015 , C07C211/11 , C07C215/12 , C07C211/30 , C07C229/26 , A61K31/40 , A61K31/155 , C07C211/27 , A61K31/64 , A61K31/505 , C07C211/35 , A61K45/06 , C07C279/14
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.
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公开(公告)号：US09957230B2
公开(公告)日：2018-05-01
申请号：US15594795
申请日：2017-05-15
IPC分类号： C07D207/333 , C07D233/58 , A61K31/155 , C07C279/14 , C07C229/26 , C07C217/60 , C07C215/40 , C07C215/12 , C07C215/10 , C07C211/51 , C07C211/35 , C07C211/30 , C07C211/27 , C07C211/11 , A61K45/06 , A61K38/26 , A61K31/64 , A61K31/505 , A61K31/4985 , A61K31/4015 , A61K31/40 , C07D295/027
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.
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