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公开(公告)号：US11926589B2
公开(公告)日：2024-03-12
申请号：US17625414
申请日：2020-07-06
Applicant: BASF CORPORATION , California Institute of Technology
Inventor： Sarah Reisman , Michael Rombola , Carolyn L. Ladd , Martin John McLaughlin , Stephan Zuend , Roland Goetz
IPC: C07C67/293 , C07B53/00
CPC classification number: C07C67/293 , C07B53/00 , C07B2200/07
Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a′, R10b′, R10c′, R10d′, Z and Z′ have the meanings as defined in the description.
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公开(公告)号：US20180118706A1
公开(公告)日：2018-05-03
申请号：US15848686
申请日：2017-12-20
Applicant: California Institute of Technology
Inventor： Sarah Reisman , Kangway V. Chuang , Chen Xu
IPC: C07D309/30 , C07C49/753 , C07D309/32 , C07C43/23 , C07C49/743 , C07C49/577 , C07C43/315
CPC classification number: C07D309/30 , C07C43/23 , C07C43/315 , C07C49/577 , C07C49/743 , C07C49/753 , C07D309/32
Abstract: This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby.
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公开(公告)号：US20190106400A1
公开(公告)日：2019-04-11
申请号：US16157926
申请日：2018-10-11
Applicant: California Institute of Technology
Inventor： Elliot P. Farney , Sean S. Feng , Sarah Reisman
IPC: C07D319/06 , C07C69/757 , C07C49/172
Abstract: The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates prepared thereby and processes for preparing these intermediates.
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公开(公告)号：US10392360B2
公开(公告)日：2019-08-27
申请号：US15848686
申请日：2017-12-20
Applicant: California Institute of Technology
Inventor： Sarah Reisman , Kangway V. Chuang , Chen Xu
IPC: C07D309/00 , C07D309/30 , C07C43/23 , C07C49/577 , C07C49/753 , C07D309/32 , C07C43/315 , C07C49/743
Abstract: This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogs thereof and novel compounds prepared thereby.
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Patent Agency Ranking
公开(公告)号：US09862696B2
公开(公告)日：2018-01-09
申请号：US15381595
申请日：2016-12-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Sarah Reisman , Kangway V. Chuang , Chen Xu
IPC: C07D309/30 , C07C43/23 , C07C49/577 , C07C49/753 , C07D309/32 , C07C43/315 , C07C49/743
CPC classification number: C07D309/30 , C07C43/23 , C07C43/315 , C07C49/577 , C07C49/743 , C07C49/753 , C07D309/32
Abstract: This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogs thereof and novel compounds prepared thereby.
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公开(公告)号：US20220267247A1
公开(公告)日：2022-08-25
申请号：US17625414
申请日：2020-07-06
Applicant: BASF CORPORATION , California Institute of Technology
Inventor： Sarah Reisman , Michael Rombola , Carolyn L. Ladd , Martin John McLaughlin , Stephen Zuend , Roland Goetz
IPC: C07C67/293 , C07B53/00
Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a′, R10b′, R10c′, R10d′, Z and Z′ have the meanings as defined in the description.
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公开(公告)号：US20170174648A1
公开(公告)日：2017-06-22
申请号：US15381595
申请日：2016-12-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Sarah Reisman , Kangway V. Chuang , Chen Xu
IPC: C07D309/30 , C07D309/32 , C07C49/577 , C07C49/753 , C07C43/23
CPC classification number: C07D309/30 , C07C43/23 , C07C43/315 , C07C49/577 , C07C49/743 , C07C49/753 , C07D309/32
Abstract: This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby.
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8.发明授权公开(公告)号：US09541558B2
公开(公告)日：2017-01-10
申请号：US14017744
申请日：2013-09-04
Applicant: California Institute of Technology
Inventor： William M. Clemons , Kyoung-Soon Jang , Roger Nani , Sergiy Levin , Sarah Reisman
IPC: G01N33/68
CPC classification number: G01N33/6848 , G01N33/6842 , Y10T436/143333
Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
Abstract translation: 提供了设计用于富集细菌糖蛋白的半胱氨酸酰肼烟酰胺（Cyhn）试剂。 还提供了纯化游离寡糖的方法及其分析。
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公开(公告)号：US20140072981A1
公开(公告)日：2014-03-13
申请号：US14017744
申请日：2013-09-04
Applicant: California Institute of Technology
Inventor： William M. Clemons , Kyoung-Soon Jang , Roger Nani , Sergiy Levin , Sarah Reisman
IPC: G01N33/68
CPC classification number: G01N33/6848 , G01N33/6842 , Y10T436/143333
Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
Abstract translation: 提供了设计用于富集细菌糖蛋白的半胱氨酸酰肼烟酰胺（Cyhn）试剂。 还提供了纯化游离寡糖的方法及其分析。
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