公开(公告)号：US20240327934A1

公开(公告)日：2024-10-03

申请号：US18621634

申请日：2024-03-29

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Xiaotian WU ,  Hao HUANG ,  Qiqi XU

IPC: C12Q1/70 ,  B01L3/00 ,  C12Q1/6844

CPC classification number: C12Q1/701 ,  B01L3/5023 ,  C12Q1/6844 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/161

Abstract: The analysis device according to an embodiment includes a partition region including a water-soluble partition material capable of individually partitioning between reaction regions different from each other in the device.

公开(公告)号：US20250003917A1

公开(公告)日：2025-01-02

申请号：US18738839

申请日：2024-06-10

Applicant: CANON MEDICAL SYSTEMS CORPORATION ,  Nanjing University

Inventor： Xiaotian WU ,  Qiqi XU ,  Hao HUANG ,  Huangxian JU ,  Jie WU

IPC: G01N27/30 ,  C12Q1/6825 ,  C12Q1/70 ,  G01N27/327

Abstract: A method for producing an electrochemiluminescence nanoprobe according to an embodiment includes: a Pdots nanoparticle synthesis step of synthesizing a Pdots nanoparticle by polymerizing a conjugated polymer and a copolymer molecule; and a Pdots nanoparticle modification step of modifying a resulting Pdots nanoparticle using an oligonucleotide chain modified with a quencher molecule.

公开(公告)号：US20240425751A1

公开(公告)日：2024-12-26

申请号：US18738909

申请日：2024-06-10

Applicant: CANON MEDICAL SYSTEMS CORPORATION ,  Nanjing University

Inventor： Xiaotian WU ,  Qiqi XU ,  Hao HUANG ,  Chao WANG ,  Huangxian JU ,  Jie WU

IPC: C09K11/07 ,  C08F8/34 ,  C12Q1/34 ,  G01N21/76

Abstract: A method for producing an electrochemiluminescence nanoprobe according to an embodiment includes: a hot exciton nanoparticle synthesis step of polymerizing a hot exciton organic luminescent molecule and a copolymer molecule to synthesize hot exciton nanoparticles; and a hot exciton nanoparticle modification step of modifying the obtained hot exciton nanoparticles with an oligonucleotide chain modified with a quencher molecule to obtain modified hot exciton nanoparticles.

公开(公告)号：US20220127685A1

公开(公告)日：2022-04-28

申请号：US17506804

申请日：2021-10-21

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Chang TAN ,  Hao HUANG ,  Qiqi XU

IPC: C12Q1/70 ,  C12Q1/6823 ,  C12Q1/6848 ,  B01L7/00 ,  B01L3/00

Abstract: A nucleic acid detection system according to an embodiment is a nucleic acid detection system to detect a target nucleic acid in a sample and includes a thermal inactivation chamber, an amplification chamber, and a detection chamber, all of which constitute a liquid flow path. In this system, liquid flows through the thermal inactivation chamber, the amplification chamber, and the detection chamber sequentially. The thermal inactivation chamber includes a reagent to thermally inactivate and decompose the sample. The amplification chamber includes a reagent to amplify the target nucleic acid. The detection chamber includes a test strip to conduct a Cas enzyme reaction with the target nucleic acid and a lateral flow detection.

公开(公告)号：US20230384300A1

公开(公告)日：2023-11-30

申请号：US18325445

申请日：2023-05-30

Applicant: CANON MEDICAL SYSTEMS CORPORATION ,  Nanjing University

Inventor： Hao HUANG ,  Qiqi XU ,  Xiaotian WU ,  Huangxian JU ,  Jie WU

IPC: G01N33/543 ,  B82Y15/00 ,  G01N33/58

CPC classification number: G01N33/54326 ,  G01N33/582 ,  B82Y15/00

Abstract: A method for preparing an electrochemiluminescent nanoprobe according to an embodiment includes: adding a metal complex ion to an inorganic oxide nanoparticle to provide a metal-doped inorganic oxide nanoparticle; and binding a secondary antibody to the metal-doped inorganic oxide nanoparticle to provide a metal-doped inorganic oxide nanoparticle modified with the secondary antibody. The secondary antibody is configured to identify a specific antibody against nucleic acid-specific site modification.

公开(公告)号：US20240044803A1

公开(公告)日：2024-02-08

申请号：US18361335

申请日：2023-07-28

Applicant: CANON MEDICAL SYSTEMS CORPORATION ,  Nanjing University

Inventor： Hao HUANG ,  Qiqi XU ,  Xiaotian WU ,  Huangxian JU ,  Jie WU

IPC: G01N21/66 ,  G01N21/76 ,  G01N33/543

CPC classification number: G01N21/66 ,  G01N21/76 ,  G01N33/5438

Abstract: A manufacturing method for an ECL (Electrochemiluminescence)-based electrode according to an embodiment includes a step of mixing an electrocatalytic solution and metal nanoparticles and thereafter dropping a mixed particle suspension onto the surface of an electrode and obtaining a base electrode co-modified by an electrocatalyst-metal nanoparticle.