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公开(公告)号：US20170219591A1
公开(公告)日：2017-08-03
申请号：US15377091
申请日：2016-12-13
申请人： CELERA CORPORATION
发明人： Bruno DOMON , Ian MCCAFFREY , Vaibhav NARAYAN , Scott PATTERSON
IPC分类号： G01N33/574 , C12Q1/68 , C07K14/745 , C07K14/705 , C07K14/71 , C07K14/81 , C12N9/10 , C12N9/14 , C07K14/47 , C12N9/02 , C07K16/40 , C07K16/28 , C07K16/38 , C07K16/36 , C12N15/113
CPC分类号： G01N33/57438 , C07K14/4705 , C07K14/705 , C07K14/70503 , C07K14/70596 , C07K14/71 , C07K14/745 , C07K14/8114 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/36 , C07K16/38 , C07K16/40 , C07K16/4266 , C07K2317/24 , C07K2317/622 , C12N9/001 , C12N9/1044 , C12N9/14 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y103/01071 , C12Y203/02013 , C12Y306/03009 , G01N2500/00 , Y10T436/25
摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) and antibodies binds to PCAT. The present invention provides that PCAT is used as targets for screening agents that modulates the PCAT activities. Further, the present invention provides methods for treating diseases associated with pancreas.
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公开(公告)号：US20160137705A1
公开(公告)日：2016-05-19
申请号：US14861327
申请日：2015-09-22
申请人： Celera Corporation
发明人： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFREY
IPC分类号： C07K14/47 , C12Q1/68 , C07K16/30 , G01N33/574 , C12N15/113 , C07K16/18
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
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公开(公告)号：US20170350897A1
公开(公告)日：2017-12-07
申请号：US15485473
申请日：2017-04-12
申请人： CELERA CORPORATION
发明人： Steve RUBEN , Karen VAN ORDEN , Bruno DOMON , Candy LEE , Tao HE , Mehdi MESRI , Elizabeth JOSELOFF , Katherine MCKINNON , Paul MOORE , Charles BIRSE
IPC分类号： G01N33/574 , A61K47/68 , C07K14/47 , C12N15/113 , C12Q1/68 , G01N33/68 , C07K16/18 , A61K39/00 , A61K38/00
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
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公开(公告)号：US20180251502A1
公开(公告)日：2018-09-06
申请号：US15695602
申请日：2017-09-05
申请人： Celera Corporation
发明人： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFREY
IPC分类号： C07K14/47 , C12Q1/6886 , C07K16/30 , C12N15/113 , C07K16/18 , G01N33/574 , A61K39/00 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
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公开(公告)号：US20150132286A1
公开(公告)日：2015-05-14
申请号：US14489669
申请日：2014-09-18
申请人： CELERA CORPORATION
发明人： Bruno DOMON , Ian MCCAFFREY , Vaibhav NARAYAN , Scott PATTERSON
IPC分类号： C07K16/42 , G01N33/574 , C07K16/18 , C12Q1/68
CPC分类号： G01N33/57438 , C07K14/4705 , C07K14/705 , C07K14/70503 , C07K14/70596 , C07K14/71 , C07K14/745 , C07K14/8114 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/36 , C07K16/38 , C07K16/40 , C07K16/4266 , C07K2317/24 , C07K2317/622 , C12N9/001 , C12N9/1044 , C12N9/14 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y103/01071 , C12Y203/02013 , C12Y306/03009 , G01N2500/00 , Y10T436/25
摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) and antibodies binds to PCAT. The present invention provides that PCAT is used as targets for screening agents that modulates the PCAT activities. Further, the present invention provides methods for treating diseases associated with pancreas.
摘要翻译： 本发明提供了诊断和检测与胰腺相关疾病的方法。 本发明提供在胰腺疾病（PCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合PCAT。 本发明提供PCAT作为调节PCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与胰腺相关疾病的方法。
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公开(公告)号：US20140314768A9
公开(公告)日：2014-10-23
申请号：US14098888
申请日：2013-12-06
申请人： CELERA CORPORATION
发明人： Steve RUBEN , Karen VAN ORDEN , Bruno DOMON , Candy LEE , Tao HE , Mehdi MESRI , Elizabeth JOSELOFF , Katherine MCKINNON , Paul MOORE , Charles BIRSE
IPC分类号： C07K16/18 , C12Q1/68 , G01N33/574 , C07K14/47 , C12N15/113
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
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公开(公告)号：US20200325189A1
公开(公告)日：2020-10-15
申请号：US16744571
申请日：2020-01-16
申请人： Celera Corporation
发明人： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFREY
IPC分类号： C07K14/47 , G01N33/574 , C07K16/18 , C07K16/30 , C12N15/113 , C12Q1/6886
摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
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公开(公告)号：US20140178391A1
公开(公告)日：2014-06-26
申请号：US14057434
申请日：2013-10-18
申请人： Celera Corporation
发明人： Bruno DOMON , Aiqun LI , Tao HE , Ian MCCAFFREY
IPC分类号： C07K16/18 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/3046 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57419
摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
摘要翻译： 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。
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公开(公告)号：US20130177566A1
公开(公告)日：2013-07-11
申请号：US13670293
申请日：2012-11-06
申请人： Celera Corporation
发明人： Steve RUBEN , Karen VAN ORDEN , Bruno DOMON , Candy LEE , Tao HE , Mehdi MESRI , Elizabeth JOSELOFF , Katherine MCKINNON , Paul MOORE , Charles BIRSE
IPC分类号： G01N33/68
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
摘要翻译： 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。
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公开(公告)号：US20200276329A1
公开(公告)日：2020-09-03
申请号：US16737051
申请日：2020-01-08
申请人： CELERA CORPORATION
发明人： Steve RUBEN , Karen VAN ORDEN , Bruno DOMON , Candy LEE , Tao HE , Mehdi MESRI , Elizabeth JOSELOFF , Katherine MCKINNON , Paul MOORE , Charles BIRSE
IPC分类号： A61K47/68 , G01N33/574 , G01N33/68 , C07K14/47 , C07K16/18 , C12N15/113 , C12Q1/6886
摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
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