公开(公告)号：US11708564B2

公开(公告)日：2023-07-25

申请号：US16629435

申请日：2018-07-12

Applicant: CJ CheilJedang Corporation

Inventor： Jinseung Park ,  Bo Seong Park ,  Young Lyeol Yang ,  In Seok Oh ,  Nahum Lee ,  Jun Ok Moon

IPC: C12N9/02 ,  C12P13/00 ,  C12N15/70

CPC classification number: C12N9/0004 ,  C12N15/70 ,  C12P13/001 ,  C12Y121/04001

Abstract: The present disclosure relates to a microorganism expressing active D-proline reductase.

公开(公告)号：US09758771B2

公开(公告)日：2017-09-12

申请号：US14392186

申请日：2014-06-24

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sang Hee Park ,  Jun Ok Moon ,  Kwang Ho Lee

IPC: C12N9/12 ,  C12P13/08 ,  C12N15/77

CPC classification number: C12N9/1247 ,  C12N15/77 ,  C12P13/08 ,  C12Y207/07006

Abstract: Provided are a beta prime subunit mutant of RNA polymerase, a microorganism of the Corynebacterium genus including a polynucleotide coding the same, and a method for producing L-lysine by culturing the same.

公开(公告)号：US10208325B2

公开(公告)日：2019-02-19

申请号：US15309387

申请日：2015-05-08

Applicant: CJ Cheiljedang Corporation

Inventor： Peter Lee ,  Jun Ok Moon ,  Hyung Joon Kim ,  Song Gi Ryu

IPC: C12P13/08 ,  C07K14/34 ,  C12N9/16 ,  C12R1/15

Abstract: Provided are a microorganism of the genus Corynebacterium having an enhanced activity to produce L-lysine as a result of inactivating a secretory protein and a method for producing L-lysine using the microorganism.

公开(公告)号：US20180037615A1

公开(公告)日：2018-02-08

申请号：US15508662

申请日：2015-09-04

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Lan Huh ,  Kwang Ho Lee ,  Hyung Joon Kim ,  Jun Ok Moon ,  Song-Gi Ryu

IPC: C07K14/34 ,  C12R1/15 ,  C12P13/08

Abstract: The present disclosure relates to a novel modified RNA polymerase sigma factor A (SigA) polypeptide; a polynucleotide encoding the same; a microorganism containing the polypeptide; and a method for producing L-lysine using the microorganism.

公开(公告)号：US09777282B2

公开(公告)日：2017-10-03

申请号：US15103147

申请日：2014-12-08

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Jun Ok Moon ,  Sang Hee Park ,  Lan Huh ,  Kwang Ho Lee

IPC: C12P13/08 ,  C07K14/34 ,  C12N15/77 ,  C12N1/21 ,  C12R1/15

CPC classification number: C12N15/77 ,  C07K14/34 ,  C12P13/08 ,  C12R1/15

Abstract: A microorganism of the genus Corynebacterium with an improved ability to produce L-lysine in which a septum formation initiator protein is inactivated and a method for producing L-lysine using the microorganism.

公开(公告)号：US09593354B2

公开(公告)日：2017-03-14

申请号：US14367818

申请日：2012-12-21

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Kwang Ho Lee ,  Sang Jo Lim ,  Jun Ok Moon ,  Jae Woo Jang ,  Su Jin Park ,  Sang Hee Park

IPC: C12P13/08 ,  C12N9/12 ,  C12N9/00 ,  C12N9/10 ,  C12N15/52 ,  C12N15/74 ,  C12N15/63

CPC classification number: C12P13/08 ,  C12N9/1022 ,  C12N9/1217 ,  C12N9/93 ,  C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12Y202/01001 ,  C12Y207/02004 ,  C12Y604/01001 ,  Y02P20/52

Abstract: The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1; hereinafter, referred to as Tkt) or pyruvate carboxylase (EC:6.4.1.1; hereinafter, referred to as Pyc), in which the initiation codon is substituted with ATG, a vector including the same, a microorganism transformed with the vector, and a method for producing L-lysine using the same.

Abstract translation: 本发明涉及编码天冬氨酸激酶（EC：2.7.2.4;以下称为LysC），转酮醇酯酶（EC：2.2.1.1;以下称为Tkt）或丙酮酸羧化酶（EC：6.4.1.1 ;以下称为Pyc），其中起始密码子被ATG取代，含有该起始密码子的载体，用载体转化的微生物和使用其的L-赖氨酸的制备方法。

公开(公告)号：US09556463B2

公开(公告)日：2017-01-31

申请号：US14514297

申请日：2014-10-14

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Un Hwan Ha ,  Yong Jae Kim ,  Jung Hoon Lee ,  Hee Sung Shin ,  Jun Ok Moon ,  Hyung Joon Kim ,  Kwang Ho Lee

IPC: C12N1/20 ,  C07K14/34 ,  C12P13/08 ,  C12N9/10 ,  C12N9/06

CPC classification number: C12P13/08 ,  C07K14/34 ,  C12N1/20 ,  C12N9/0014 ,  C12N9/1025 ,  C12Y104/99001

Abstract: The present invention relates to a novel isolated gene (polynucleotide) which encodes a protein having a biofilm formation inhibitory activity derived from Coryneform bacteria, a L-lysine-producing strain in which the polynucleotide is inactivated, and a method for producing L-lysine using the same.

Abstract translation: 本发明涉及编码具有衍生自棒状细菌的生物膜形成抑制活性的蛋白质的新型分离基因（多核苷酸），其中多核苷酸失活的L-赖氨酸生产菌株及其制备方法，使用 一样。

公开(公告)号：US20140356518A1

公开(公告)日：2014-12-04

申请号：US14362036

申请日：2012-10-17

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sang Hee Park ,  Jun Ok Moon ,  Sang Jo Lim ,  Do Hyun Kwon ,  Kyung Han Lee ,  Jin Suck Sung ,  Hyun Joon Kim

IPC: C12P17/12 ,  C12P13/08 ,  A23K1/16 ,  C12N1/20

CPC classification number: C12P17/12 ,  A23K20/142 ,  A23V2002/00 ,  C12N1/20 ,  C12P13/08 ,  C12P25/00 ,  C12R1/15

Abstract: The present invention relates to a method for producing highly-concentrated L-amino acid and riboflavin simultaneously, and a microorganism for simultaneously producing L-amino acid and riboflavin. Specifically, the present invention relates to a modified microorganism for producing L-lysine or L-threonine, and riboflavin simultaneously, wherein the microorganism belonging to Corynebacterium sp. capable of producing L-lysine or L-threonine is modified by enhancing the activity of an enzyme family expressed by a rib operon which contains riboflavin biosynthesis gene family. Also, the present invention relates to a method for the simultaneous production of L-lysine or L-threonine, and riboflavin using the modified microorganism, and relates to a formulation or granular formulation, feed, and feed additive, containing L-lysine or L-threonine, and riboflavin produced from a culture medium of the modified microorganism.

Abstract translation: 本发明涉及同时生产高浓度L-氨基酸和核黄素的方法，以及同时生产L-氨基酸和核黄素的微生物。 具体地说，本发明涉及同时生产L-赖氨酸或L-苏氨酸和核黄素的改良微生物，其中属于棒状杆菌属（Corynebacterium sp。）的微生物。 能够通过增强由含有核黄素生物合成基因家族的rib操纵子表达的酶家族的活性来修饰能够产生L-赖氨酸或L-苏氨酸的能力。 此外，本发明涉及使用该修饰微生物同时生产L-赖氨酸或L-苏氨酸和核黄素的方法，涉及含有L-赖氨酸或L的制剂或颗粒制剂，饲料和饲料添加剂 - 苏氨酸和由修饰微生物的培养基产生的核黄素。

公开(公告)号：US12252502B2

公开(公告)日：2025-03-18

申请号：US17311743

申请日：2019-11-29

Applicant: CJ CheilJedang Corporation

Inventor： Jinwoo Jeon ,  Joo Young Lee ,  Changsuk Lee ,  Hyunjin Kim ,  Jun Ok Moon ,  In Seok Oh

IPC: C07F9/54 ,  C07C231/12 ,  C07D307/33 ,  C07F7/18 ,  C07F9/30 ,  C07F9/32

Abstract: Provided are L-glufosinate intermediate preparation method or L-glufosinate preparation method, the method, for preparing L-glufosinate intermediate or L-glufosinate from an L-homoserine derivative, comprising a step of preparing a compound of Chemical Formula 2 from a compound of Chemical Formula 1.

公开(公告)号：US12186303B2

公开(公告)日：2025-01-07

申请号：US17287356

申请日：2019-11-12

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Jin Seung Park ,  Jin Woo Jeon ,  Jun Ok Moon ,  Joo Young Lee ,  Hong-Gu Lee ,  Jae-Sung Lee

IPC: A61K31/405 ,  A23K20/142 ,  A23K50/10 ,  A61K9/00 ,  A61P3/02

Abstract: Provided are a feed additive composition for cattle including N-acetyl-L-tryptophan (NALT) as an active ingredient, and more particularly, a feed additive composition including N-acetyl-L-tryptophan as an active ingredient for reducing temperature stress of cattle, increasing average daily gain of cattle, and increasing feed intake of cattle; a feed including the feed additive composition for cattle; and methods of reducing temperature stress of cattle, increasing average daily gain of cattle, and increasing feed intake of cattle, the methods including feeding the cattle with the feed additive composition or feed for cattle including N-acetyl-L-tryptophan as an active ingredient.