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公开(公告)号：US20210137815A1
公开(公告)日：2021-05-13
申请号：US17248391
申请日：2021-01-22
Applicant: Colgate-Palmolive Company
Inventor： Lynette Zaidel , Guisheng Pan , Suman Chopra , Prakasarao Mandadi , Michael Prencipe
IPC: A61K8/81 , A61K8/02 , A61K8/22 , A61Q11/00 , A61Q11/02 , A61K8/24 , A61K8/90 , A61K8/49 , A61K8/891
Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
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公开(公告)号：US10918588B2
公开(公告)日：2021-02-16
申请号：US14441782
申请日：2013-11-08
Applicant: COLGATE-PALMOLIVE COMPANY , HOWARD UNIVERSITY
Inventor： Tongxin Wang , Yanda Lei , James W. Mitchell , Lynette Zaidel , Jian-hong Qiu , Mahmoud Hassan
Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.
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公开(公告)号：US09625449B2
公开(公告)日：2017-04-18
申请号：US14580485
申请日：2014-12-23
Applicant: Colgate-Palmolive Company
Inventor： Stanislav Jaracz , Harsh M. Trivedi , Lyndsay Schaeffer-Korbylo , Lynette Zaidel
CPC classification number: G01N33/5082 , G01N21/78 , G01N33/84
Abstract: An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample, contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.
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公开(公告)号：US10758472B2
公开(公告)日：2020-09-01
申请号：US15900346
申请日：2018-02-20
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Lynette Zaidel , Guisheng Pan , Suman Chopra , Prakasarao Mandadi , Michael Prencipe
IPC: A61K8/00 , A61K8/81 , A61K8/02 , A61K8/22 , A61Q11/00 , A61Q11/02 , A61K8/24 , A61K8/90 , A61K8/49 , A61K8/891
Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
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Patent Agency Ranking
公开(公告)号：US20160178617A1
公开(公告)日：2016-06-23
申请号：US14580485
申请日：2014-12-23
Applicant: Colgate-Palmolive Company
Inventor： Stanislav Jaracz , Harsh M. Trivedi , Lyndsay Schaeffer-Korbylo , Lynette Zaidel
CPC classification number: G01N33/5082 , G01N21/78 , G01N33/84
Abstract: An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample., contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.
Abstract translation: 用于测定来自口腔护理组合物的锌（II）离子的生物利用度的体外方法包括：提供包含口腔护理组合物的样品; 将样品与生物相关底物接触，将生物相关底物与样品分离;在选择的条件下使生物相关底物与指示剂接触，使得指示剂能够与锌（II）离子反应，并确定指示剂的吸光度 。 指示剂是钦康或其盐。 该方法可用于估计口腔护理组合物将治疗活性的锌（II）离子递送至口腔的能力。 还提供了在体外使用锌康和生物相关底物来确定来自包含锌源的口腔护理组合物的锌（II）离子的生物利用度。
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公开(公告)号：US11490623B2
公开(公告)日：2022-11-08
申请号：US16846770
申请日：2020-04-13
Inventor： Carl Myers , Carlo Daep , Lynette Zaidel , James Masters , Russell Composto , Hyun-Su Lee
IPC: A01N47/44 , C11D3/37 , A61K31/785 , A61Q17/00 , C11D3/48 , A61Q11/00 , C08F126/02 , A61K8/91 , A01N25/08 , A61K8/81 , C08F8/30 , C09D5/14 , C09D139/00
Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
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公开(公告)号：US20140134116A1
公开(公告)日：2014-05-15
申请号：US14075230
申请日：2013-11-08
Applicant: Colgate-Palmolive Company , Howard University
Inventor： Tongxin Wang , Yanda Lei , James W. Mitchell , Lynette Zaidel , Jianhong Qiu , Mahmoud Hassan
CPC classification number: A61K8/90 , A61K8/21 , A61Q11/00 , C08F293/005
Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same are also described.
Abstract translation: 这里描述的是具有疏水性嵌段和亲水性嵌段的嵌段共聚物，该嵌段共聚物有效结合硬组织的表面; 还描述了包含它们的组合物，以及制备和使用它们的方法。
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公开(公告)号：US11596593B2
公开(公告)日：2023-03-07
申请号：US17248391
申请日：2021-01-22
Applicant: Colgate-Palmolive Company
Inventor： Lynette Zaidel , Guisheng Pan , Suman Chopra , Prakasarao Mandadi , Michael Prencipe
IPC: A61K8/22 , A61K8/81 , A61K8/02 , A61Q11/00 , A61Q11/02 , A61K8/24 , A61K8/90 , A61K8/49 , A61K8/891
Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
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公开(公告)号：US10653149B2
公开(公告)日：2020-05-19
申请号：US15788852
申请日：2017-10-20
Inventor： Carl Myers , Carlo Daep , Lynette Zaidel , James Masters , Russell Composto , Hyun-Su Lee
IPC: A61K31/785 , A61Q11/00 , C08F126/02 , A01N47/44 , C11D3/37 , A61Q17/00 , C11D3/48 , A61K8/81 , C08F8/30 , C09D5/14 , C09D139/00 , A61K8/91 , A01N25/08
Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
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