公开(公告)号：US20170173087A1

公开(公告)日：2017-06-22

申请号：US15129611

申请日：2015-03-27

申请人： CONJUGON, INC.

发明人： Steven R. Watt ,  Caleb W. Dorsey ,  Joshua A. Smith

IPC分类号： A61K35/741 ,  C12N1/20 ,  A61K9/00 ,  C12N1/32 ,  A61M25/00 ,  A61L29/14

CPC分类号： A61K35/741 ,  A61K9/0034 ,  A61K35/74 ,  A61L29/005 ,  A61L29/085 ,  A61L29/145 ,  A61L2400/10 ,  A61M25/0017 ,  A61M25/0045 ,  A61M2025/0046 ,  C12N1/20 ,  C12N1/32 ,  C12N1/38 ,  C12N2500/05 ,  C12N2500/14 ,  C12N2500/16 ,  C12N2500/20 ,  C12N2500/22 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/60 ,  Y02A50/473

摘要： The invention relates to methods of differentiation, isolation, propagation, and storage of small colony variants (SCVs) of E. coli, preferably E. coli 83972 or E. coli HU2117, or modified or variant forms thereof, and methods for using the pre-pared SCV bacteria to establish probiotic biofilms in treated subjects and/or on treated medical devices.