公开(公告)号：US09518898B2

公开(公告)日：2016-12-13

申请号：US14077707

申请日：2013-11-12

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios

IPC: F25B19/00 ,  G01N1/28 ,  A01N1/02 ,  C12M1/00

CPC classification number: G01N1/28 ,  A01N1/0268 ,  C12M45/22

Abstract: A container or vial for the cryopreservation and/or vitrification and storage of a biological sample, including cellular samples and embryos is described. The container comprises a sealable closure that isolates a biological sample held in the container lumen from the external environment and is suitable for storage of the sample in liquid nitrogen. Methods for introducing and sealing biological samples within the container for cryopreservation and/or vitrification and storage are also described.

Abstract translation: 描述了用于生物样品（包括细胞样品和胚胎）的冷冻保存和/或玻璃化和储存的容器或小瓶。 容器包括可密封的封闭物，其将保持在容器腔中的生物样品与外部环境隔离，并且适于将样品储存在液氮中。 还描述了用于将容器内的生物样品引入和密封用于冷冻保存和/或玻璃化和储存的方法。

公开(公告)号：US11856947B2

公开(公告)日：2024-01-02

申请号：US17174638

申请日：2021-02-12

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios

IPC: A01N1/02 ,  B01L3/00

CPC classification number: A01N1/0268 ,  A01N1/0221 ,  A01N1/0242 ,  B01L3/502

Abstract: A device for permeation of a biological material may include a lower portion and an upper portion configured to be releasably coupled to the lower portion. The lower portion may include a groove configured to receivingly support a biological material. The lower portion and the upper portion may be coupled such that a first reservoir and a second reservoir are formed collectively by the lower portion and the upper portion. The first reservoir, the second reservoir, and the groove may be in fluid communication with each other.

公开(公告)号：US09297499B2

公开(公告)日：2016-03-29

申请号：US14097357

申请日：2013-12-05

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios ,  Bryan D. Woodard ,  Shawn Nichols ,  Scott K. Philhower ,  Barry B. Hoult

IPC: F25D25/00 ,  F17C13/00 ,  F25D3/10 ,  A01N1/02 ,  B01L7/00 ,  B01L9/06

CPC classification number: F17C13/001 ,  A01N1/0257 ,  A01N1/0268 ,  B01L7/50 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1883 ,  F25D3/10

Abstract: A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.

Abstract translation: 描述了用于冷冻介质中生物样品的冷冻保存和/或玻璃化的装置。 该装置优选地包括用于接收含有液相氮中的生物样品的容器的浴。 在一个示例中，浴包括从底壁部分大致垂直延伸的第一构件，该底壁部分将浴室的内部腔分成适于接收一定体积的低温冷冻介质的第一子室，以及适于 以从第一子室接收冷冻介质。 第二构件在浴的侧壁部分之间大致水平地延伸，并且包括用于接收含生物样品的容器的至少一个开口。 还描述了包括低温存储装置和容器的试剂盒。

公开(公告)号：US20140157798A1

公开(公告)日：2014-06-12

申请号：US14097357

申请日：2013-12-05

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios ,  Bryan D. Woodard ,  Shawn Nichols ,  Scott K. Philhower ,  Barry B. Hoult

IPC: F17C13/00 ,  F25D3/10

CPC classification number: F17C13/001 ,  A01N1/0257 ,  A01N1/0268 ,  B01L7/50 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1883 ,  F25D3/10

Abstract: A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.

Abstract translation: 描述了用于冷冻介质中生物样品的冷冻保存和/或玻璃化的装置。 该装置优选地包括用于接收含有液相氮中的生物样品的容器的浴。 在一个示例中，浴包括从底壁部分大致垂直延伸的第一构件，该底壁部分将浴室的内部腔分成适于接收一定体积的低温冷冻介质的第一子室，以及适于 以从第一子室接收冷冻介质。 第二构件在浴的侧壁部分之间大致水平地延伸，并且包括用于接收含生物样品的容器的至少一个开口。 还描述了包括低温存储装置和容器的试剂盒。

公开(公告)号：US20240123442A1

公开(公告)日：2024-04-18

申请号：US18485495

申请日：2023-10-12

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios ,  Victor Havill ,  Donald R. Sandmore

IPC: B01L3/00

CPC classification number: B01L3/50 ,  B01L2200/0689

Abstract: A sealable container for preservation of a biological sample is provided. The sealable container includes a cap and an elongate body. The cap has a proximal open end and a distal end with a lumen extending from the proximal open end to the distal end. The elongate body extends from a handle portion to a specimen portion, where the specimen portion is configured to receive a biological sample thereon. The elongate body further includes a closure portion disposed between the handle portion and the specimen portion, where the closure portion is configured to make surface to surface contact with the cap when the specimen portion of the elongate body is fully inserted within the lumen of the cap. At least one of an inner surface of the cap and an outer surface of the elongate body includes a textured area with a textured surface finish.

公开(公告)号：US20210085921A1

公开(公告)日：2021-03-25

申请号：US17026557

申请日：2020-09-21

Applicant: Cook Medical Technologies LLC

Inventor： Erin Roberts ,  Elizabeth M. Brown ,  Jorge L. Jimenez-Rios ,  Lyle Hundley ,  Johnny P. Smith ,  Jonathan Sheets ,  Jaimie Jarboe ,  Nathan Steinbrunner ,  Cayley Gubser ,  Jeffry S. Melsheimer ,  Samantha Charley ,  Tyler Dow ,  Kathryn R. Hardert ,  David Gordon ,  Mitchell T. Aman ,  Kristen M. Bunch

IPC: A61M25/00 ,  A61M25/01

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use thereof, and methods of manufacturing. In one embodiment a strain relief member may include a support having a first end with a first outer diameter, a second end having a second outer diameter, an inner surface facing a support lumen that extends axially through the support along a longitudinal axis, and an outer surface opposite to the inner surface. An embodiment may also include an overlay coupled to a portion of the outer surface of the support, where the overlay comprises a first material and the support comprises a second material, and the first material is more flexible than the second material. A liner may be disposed in a portion of the support lumen and a first connector disposed over a portion of the support.

公开(公告)号：US20210085161A1

公开(公告)日：2021-03-25

申请号：US17025708

申请日：2020-09-18

Applicant: Cook Medical Technologies LLC

Inventor： ERIN ROBERTS ,  Jorge L. Jimenez-Rios ,  Lyle Hundley ,  Johnny P. Smith ,  Jonathan Sheets ,  Tyler Dow ,  Mitchell T. Aman ,  Kristen M. Bunch

IPC: A61B1/00 ,  A61B1/018

Abstract: A device for guiding an elongate body into a channel of a scope may include a main body extending between a proximal end portion and a distal end portion and a lumen extending through the main body. The device may be slidably attached onto the elongate body such that the elongate body may be threaded through the lumen of the device, out of the distal end portion of the main body of the device, and into the channel of the scope. When a distal end of the elongate body reaches a desired location inside the channel, the device may be moved along the elongate body from a first position to a second position, where the device may be releasably coupled with respect to the elongate body.

公开(公告)号：US11724066B2

公开(公告)日：2023-08-15

申请号：US17026557

申请日：2020-09-21

Applicant: Cook Medical Technologies LLC

Inventor： Erin Roberts ,  Elizabeth M. Brown ,  Jorge L. Jimenez-Rios ,  Lyle Hundley ,  Johnny P. Smith ,  Jonathan Sheets ,  Jaimie Jarboe ,  Nathan Steinbrunner ,  Cayley Gubser ,  Jeffry S. Melsheimer ,  Samantha Charley ,  Tyler Dow ,  Kathryn R. Hardert ,  David Gordon ,  Kristen M. Bunch

IPC: A61M25/00 ,  A61M25/01

CPC classification number: A61M25/0053 ,  A61M25/0097 ,  A61M25/0136 ,  A61M2025/0047 ,  A61M2025/0098 ,  A61M2205/02 ,  A61M2207/10

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use thereof, and methods of manufacturing. In one embodiment a strain relief member may include a support having a first end with a first outer diameter, a second end having a second outer diameter, an inner surface facing a support lumen that extends axially through the support along a longitudinal axis, and an outer surface opposite to the inner surface. An embodiment may also include an overlay coupled to a portion of the outer surface of the support, where the overlay comprises a first material and the support comprises a second material, and the first material is more flexible than the second material. A liner may be disposed in a portion of the support lumen and a first connector disposed over a portion of the support.

公开(公告)号：US11116206B2

公开(公告)日：2021-09-14

申请号：US16584458

申请日：2019-09-26

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios ,  Lyle D. Hundley ,  Victor W. Havill ,  Erin Elizabeth Roberts ,  Jaimie Michelle Jarboe

IPC: A01N1/02 ,  G01N1/42

Abstract: A sealable container for preservation of a biological sample is provided. The container includes a cap comprising a proximal open and a lumen and an elongate body that extends from a handle portion to a specimen portion. A closure portion is disposed between the handle portion and the specimen portion, wherein the closure portion is configured to make surface to surface contact with the cap when the specimen portion is fully inserted within the lumen. The closure portion comprises an outer diameter that gradually decreases in a direction from the handle portion to the specimen portion. The specimen portion comprises a scooped portion where a distance between the upper surface and the lower surface is less than distances between the upper surface and the lower surface along remaining portions of the specimen portion, wherein the scooped portion is spaced proximally from a distal tip of the specimen portion.

公开(公告)号：US20210251216A1

公开(公告)日：2021-08-19

申请号：US17174638

申请日：2021-02-12

Applicant: Cook Medical Technologies LLC

Inventor： Jorge L. Jimenez-Rios

IPC: A01N1/02

Abstract: A device for permeation of a biological material may include a lower portion and an upper portion configured to be releasably coupled to the lower portion. The lower portion may include a groove configured to receivingly support a biological material. The lower portion and the upper portion may be coupled such that a first reservoir and a second reservoir are formed collectively by the lower portion and the upper portion. The first reservoir, the second reservoir, and the groove may be in fluid communication with each other.