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公开(公告)号：US20240366482A1
公开(公告)日：2024-11-07
申请号：US18642098
申请日：2024-04-22
Applicant: CORNING INCORPORATED
Inventor： Erin Coon , Qiang Fu , Aize Li , Hugh Michael McMahon , Charisse Marye Spier , Nicholas Michael Stone-Weiss , Joanna E. Warzyszynska
Abstract: An aqueous dentifrice formulation, comprising: a bioactive glass exhibiting at least one of: a hydrolytic resistance of glass grains (HGB) of at most 4, when measured by International Organization for Standardization section 719 (ISO 719); a weight loss of 5 wt. % or less after soaking 5 g of the bioactive glass in powder form in 100 mL of deionized water for 7 days at 37° C.; an XRD spectrum substantially free of crystalline phase after soaking 5 g of the bioactive glass in powder form in 100 mL of deionized water for 7 days at 37° C.; or any combination thereof; wherein, when the bioactive glass is contacted with artificial saliva, the bioactive glass forms a bioactive crystalline phase. A method of using the aqueous dentifrice formulation to remineralize enamel of the tooth, treat caries of the tooth, treat dentin hypersensitivity of the tooth, or any combination thereof.
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公开(公告)号：US20240325263A1
公开(公告)日：2024-10-03
申请号：US18613863
申请日：2024-03-22
Applicant: CORNING INCORPORATED
Inventor： Qiang Fu , Charisse Marye Spier , Nicholas Michael Stone-Weiss
CPC classification number: A61K8/25 , A61K8/19 , A61K8/21 , A61K8/28 , A61Q11/00 , A61K2800/28 , A61K2800/30
Abstract: Glass compositions comprising 15-50 wt. % SiO2, 25-60 wt. % CaO, 3-30 wt. % P2O5, 0.5-15 wt. % ZrO2, and >0-5 wt. % F, wherein, when subjected to artificial saliva, the glass composition forms a bioactive crystalline phase, such as apatite. A matrix comprising the glass composition, wherein the glass composition is attached to the matrix or mixed therein, in which the matrix includes at least one of: a toothpaste, mouthwash, gel, varnish, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation. The matrix may be a dentifrice composition. A method comprising applying the matrix to a tooth, in which the method remineralizes enamel of the tooth, treats caries of the tooth, treats dentin hypersensitivity of the tooth, or any combination thereof.
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公开(公告)号：US20250121351A1
公开(公告)日：2025-04-17
申请号：US18893022
申请日：2024-09-23
Applicant: CORNING INCORPORATED
Abstract: A method for forming fluorite from a F−-containing aqueous fluid, the method comprising: contacting a bioactive glass comprising calcium with the F−-containing aqueous fluid; and forming the fluorite. A filter media, and filter containing the filter media, for forming fluorite from a F−-containing aqueous fluid, the filter media comprising: a bioactive glass comprising calcium; and at least one of sand, gravel, charcoal, polymer particles, and ceramic particles.
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公开(公告)号：US20240325264A1
公开(公告)日：2024-10-03
申请号：US18613904
申请日：2024-03-22
Applicant: CORNING INCORPORATED
Inventor： Qiang Fu , Nicholas Michael Stone-Weiss , Joanna E. Warzyszynska
CPC classification number: A61K8/27 , A61K8/24 , A61Q11/00 , A61Q19/08 , A61K2800/5922 , A61K2800/60 , A61K2800/80
Abstract: A composition comprising an amino acid and a bioactive glass, in which the bioactive glass comprises 15-55 wt. % SiO2, 20-60 wt. % CaO, 0.1-15 wt. % ZrO2, and 5-30 wt. % P2O5, in which, when the composition is subjected to artificial saliva at 37° C., a bioactive crystalline phase is formed within 7 days. In some aspects, the bioactive crystalline phase is apatite, and the composition is a dentifrice or skin care composition. Methods comprising making the composition, making the bioactive glass, and applying the composition to a tooth or the skin. In some aspects, applying the composition to a tooth remineralizes enamel of the tooth, treats caries of the tooth, and/or treats dentin hypersensitivity of the tooth, and applying the composition to skin treats or reduces the appearance of one or more skin defects, such as wrinkles and blemishes.
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