公开(公告)号：US20230234918A1

公开(公告)日：2023-07-27

申请号：US18042169

申请日：2021-08-24

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventor： Ajay Kumar SINGH ,  Srihari PABBARAJA ,  Deepak Kumar JAISWAL ,  Dnyaneshwar AAND ,  Abhilash RANA

IPC: C07C245/16 ,  B01J19/24 ,  B01J19/00

CPC classification number: C07C245/16 ,  B01J19/0093 ,  B01J19/2415 ,  B01J2219/00905

Abstract: A process for producing diazomethane of Formula 1 (CH2N2), with an automated apparatus is described. A stock solution of N-methyl-N-nitroso amine in an organic solvent is continuously flown and mixed with an aqueous inorganic base at a T-mixer to form a mixture. Then it is passed through a capillary micro reactor at a temperature in a range of 20 to 30° C. to form diazomethane. The mixture is separated into an aqueous layer and an organic layer using a continuous flow micro-separator. The organic layer has 0.1-0.4 M diazomethane. The organic layer is reacted with a carboxylic acid, phenol, an alkyne, an anhydride, a carboxyl metal organic framework (MOF), or MOF coated cotton to form a corresponding ester, a pyrazole, an ether, a diazo ketone, a stable carboxyl MOF or a stable MOF coated cotton fiber.

公开(公告)号：US20240002348A1

公开(公告)日：2024-01-04

申请号：US18042570

申请日：2021-08-17

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN

Inventor： Srihari PABBARAJA ,  Goverdhan MEHTA ,  Shweta SINGH

IPC: C07D215/233 ,  C07D471/04 ,  C07D491/056 ,  C07D405/08

CPC classification number: C07D215/233 ,  C07D405/08 ,  C07D491/056 ,  C07D471/04

Abstract: The present invention relates to quinolones of formula (I) and process for its preparation by amine insertion into aryl-ynones thereof. [Formula I] The invention further relates to the process to obtain the natural products such as: graveoline, graveolinine, pseudane IV, pseudane VII, pseudane VIII and pseudane XII. The invention also describes the process for the total synthesis of waltherione F in concise approach from the quinolone synthesized. [Formula II]

公开(公告)号：US20220333139A1

公开(公告)日：2022-10-20

申请号：US17621052

申请日：2020-06-17

Applicant: Council of Scientific and Industrial Research

Inventor： Srivari CHANDRASEKHAR ,  Subhash GHOSH ,  Avula Shiva KRISHNA ,  Chada Raji REDDY ,  Gangarajula SUDHAKAR ,  Kumaraguru THENKRISHNAN ,  Srihari PABBARAJA ,  Prathama Satyendra MAINKAR ,  Rajesh NASAM

IPC: C12P7/04 ,  C12P7/625 ,  C12P41/00 ,  C12N9/20

Abstract: The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.