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    Ablation probe with deployable sensors
    1.
    发明授权
    Ablation probe with deployable sensors 有权

    公开(公告)号：US11129662B2

    公开(公告)日：2021-09-28

    申请号：US16030933

    申请日：2018-07-10

    申请人： CPSI HOLDINGS LLC

    发明人： Marie Molnar-Hammond ,  John M. Baust

    IPC分类号： A61B18/02 ,  A61B18/14 ,  A61B17/00 ,  A61B18/00

    摘要： The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.

    CELL SELECTION METHOD
    3.
    发明申请
    CELL SELECTION METHOD 审中-公开
    细胞选择方法

    公开(公告)号：US20160068804A1

    公开(公告)日：2016-03-10

    申请号：US14819960

    申请日：2015-08-06

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  John G. Baust ,  William L. Corwin ,  Robert G. Van Buskirk

    IPC分类号： C12N5/00 ,  C12N5/0735 ,  C12N5/074

    CPC分类号： C12N5/0081 ,  A61K31/05 ,  A61K31/07 ,  A61K31/34 ,  A61K31/355 ,  A61K31/47 ,  A61K31/593 ,  C12N5/00 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/02 ,  C12N2500/60 ,  C12N2502/02 ,  C12N2502/45 ,  C12N2523/00 ,  G01N33/5008

    摘要： A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Laboratory experiments have demonstrated the use of cell-guard agents and/or target-specific supplements in the bioprocessing of cells as well as in selecting out a desired cell population. Several potential additive agents (both natural and synthetic) have been identified during these studies, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery. The cell-guard agents are process-matched and cell-matched to protect and/or select particular cells during laboratory and clinical manipulation. The components modulate cell stress and survival pathways.

    摘要翻译： 已经鉴定出新的一类试剂用作细胞保护剂和/或靶标特异性补充物以增加细胞质量和产量，以及选择靶细胞群体。 实验室实验已经证明了在细胞的生物处理中以及选择所需的细胞群体中使用细胞保护剂和/或靶标特异性补充物。 在这些研究中已经鉴定了几种潜在的添加剂（天然和合成），包括在细胞模型中有希望应用的维生素D3，NAC，白藜芦醇，salubrinal，AKT和衣霉素（等）。 在一个实施方案中，利用低温胁迫方案。 在另一个实施方案中，在加工过程中测试其它应激物时，使用常温条件。 保持大量细胞培养和/或选择特定细胞群以进行进一步研究和临床应用的方法代表治疗发现中的重要步骤。 细胞保护剂在过程匹配和细胞匹配以在实验室和临床操作期间保护和/或选择特定的细胞。 组分调节细胞应激和存活途径。

    Cryotreatment pellet
    4.
    发明授权
    Cryotreatment pellet 有权
    冷冻沉淀

    公开(公告)号：US08747397B2

    公开(公告)日：2014-06-10

    申请号：US13683140

    申请日：2012-11-21

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  John G. Baust ,  Anthony T. Robilotto ,  Kristi K. Snyder ,  Robert G. Van Buskirk

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2018/0212 ,  A61K9/0024 ,  A61K9/145 ,  A61K31/00 ,  A61K31/282 ,  A61K31/337 ,  A61K31/513 ,  A61K31/59 ,  A61K31/7048 ,  A61K45/06 ,  A61M5/44 ,  A61M37/0069 ,  A61M2205/3606

    摘要： The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment.

    摘要翻译： 可再吸收的冷冻探针装置和方法是用于治疗局部疾病的新方法，其允许在自包含的基质/包装内精确地联合应用冷冻温度和细胞毒性或冷冻敏化剂以优化组织破坏。 冷冻条由包括产生低于零温度的冷冻源的组分的列表组成，含有细胞毒剂，细胞毒性剂和递送包的多孔基质。 本文提供的数据显示了这种方法在破坏癌组织中的功效。 例如，将冻结温度施加到-10℃导致约15％的细胞死亡，而暴露于细胞毒性剂如TRAIL的细胞会导致最小的细胞死亡。 cryopellet方法的利用导致在相同温度下产生完全细胞死亡的协同效应。 可再吸收探针应用的创新包括激活内在或外在细胞死亡反应（包括细胞凋亡和坏死），冷冻剂和细胞毒性剂的独特包装以及独特的递送系统的药剂的战略组合。 可再吸收的冷冻探针技术将有助于直接治疗癌症，并可能导致更广泛的疾病治疗应用。

    ABLATION PROBE WITH DEPLOYABLE SENSORS
    6.
    发明申请
    ABLATION PROBE WITH DEPLOYABLE SENSORS 有权

    公开(公告)号：US20210386467A1

    公开(公告)日：2021-12-16

    申请号：US17460948

    申请日：2021-08-30

    申请人： CPSI HOLDINGS LLC

    发明人： Marie Molnar-Hammond ,  John M. Baust

    IPC分类号： A61B18/02 ,  A61B18/14

    摘要： The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.

    Endoscopic cryoablation catheter
    7.
    发明授权
    Endoscopic cryoablation catheter 有权

    公开(公告)号：US10918432B2

    公开(公告)日：2021-02-16

    申请号：US15881441

    申请日：2018-01-26

    申请人： CPSI HOLDINGS LLC

    发明人： John M. Baust

    IPC分类号： A61B18/02 ,  A61M25/00 ,  A61M25/01 ,  A61B18/00 ,  A61B90/00

    摘要： A cryoablation device is provided herein which, in an embodiment, includes a catheter shaft; a cryogen return line disposed within the catheter shaft; and a cryogen supply line disposed within the cryogen return line, such that the cryogen supply line, the cryogen return line, and the catheter shaft are all substantially coaxial. A needle tip probe is disposed at a distal end of the cryogen return line. The cryogen supply line extends in a distal direction beyond a distal end of the cryogen return line and into the needle tip probe, and the catheter shaft is axially movable relative to the needle tip probe and the cryogen return line, and the catheter shaft is configured such that the catheter shaft is distally extended over the needle tip probe in an extended position.

    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE
    8.
    发明申请
    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE 审中-公开

    公开(公告)号：US20180340654A1

    公开(公告)日：2018-11-29

    申请号：US16042411

    申请日：2018-07-23

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Joshua T. Smith ,  Anthony T. Robilotto ,  Jennie F. McKain

    IPC分类号： F17C1/00 ,  F17C5/02

    摘要： A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.