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公开(公告)号：US20160115195A1
公开(公告)日：2016-04-28
申请号：US14895432
申请日：2014-06-25
CPC分类号： C07K1/36 , C07K16/065 , C07K16/241 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/21 , C07K2317/24
摘要： The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography. It provides more than 99% purity of the desired monoclonal antibody.
摘要翻译： 本发明提供从细胞培养物纯化单克隆抗体的改进方法。 纯化所需单克隆抗体的方法包括亲和力，疏水相互作用和任选的离子交换柱层析。 它提供超过99％纯度的所需单克隆抗体。
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公开(公告)号：US09708365B2
公开(公告)日：2017-07-18
申请号：US14895432
申请日：2014-06-25
CPC分类号： C07K1/36 , C07K16/065 , C07K16/241 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/21 , C07K2317/24
摘要： The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography. It provides more than 99% purity of the desired monoclonal antibody.
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公开(公告)号：US20160200792A1
公开(公告)日：2016-07-14
申请号：US14912984
申请日：2014-08-21
IPC分类号： C07K14/635 , B01D15/36 , C07K1/18
CPC分类号： C07K14/635 , B01D15/363 , C07K1/18
摘要： The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH1-34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) Enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.
摘要翻译： 本发明涉及用于纯化重组甲状旁腺激素（rhPTH1-34或特立帕定）的改进方法，所述方法用于纯化甲状旁腺激素，其包括以下必要步骤：（a）酶切; （b）阴离子交换层析，然后进行其他合适的纯化步骤; 其中步骤（a）和（b）可以以任何顺序进行。
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