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公开(公告)号：US20230047111A1
公开(公告)日：2023-02-16
申请号：US17890866
申请日：2022-08-18
摘要： The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are useful for stabilization of antibody preparations. Additionally, the novel formulation of the present invention prevents the formation of aggregates or fragments or modification of protein in solution.
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公开(公告)号：US20170029482A1
公开(公告)日：2017-02-02
申请号：US15303888
申请日：2015-04-17
IPC分类号： C07K14/59
CPC分类号： C07K14/59
摘要： The present invention provides an improved method for the purification of desired gonadotropin from a crude mixture containing at least one contaminating protein. The process of purification of the desired gonadotropin according to the present invention comprises use of an affinity chromatography as the first column purification step, prior to use of any column chromatography steps for further purification. Such purification process may further include ion exchange and/or hydrophobic interaction chromatography step to obtain substantially purified gonadotropin protein with desired isoforms profile.
摘要翻译： 本发明提供了一种从含有至少一种污染蛋白质的粗混合物中纯化所需促性腺激素的改进方法。 在使用任何柱色谱步骤进一步纯化之前，根据本发明的纯化所需促性腺激素的方法包括使用亲和层析作为第一柱纯化步骤。 这样的纯化方法还可以包括离子交换和/或疏水相互作用层析步骤，以获得具有所需同种型谱的基本上纯化的促性腺激素蛋白。
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公开(公告)号：US10093728B2
公开(公告)日：2018-10-09
申请号：US14383533
申请日：2013-03-05
IPC分类号： C07K16/24 , A61K39/395 , A61K9/19 , A61K47/18 , A61K47/26
摘要： The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are useful for stabilization of antibody preparations. Additionally, the novel formulations of the present invention prevents the formation of aggregates or fragments or modifications of protein in solution.
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公开(公告)号：US09708365B2
公开(公告)日：2017-07-18
申请号：US14895432
申请日：2014-06-25
CPC分类号： C07K1/36 , C07K16/065 , C07K16/241 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/21 , C07K2317/24
摘要： The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography. It provides more than 99% purity of the desired monoclonal antibody.
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公开(公告)号：US20160200792A1
公开(公告)日：2016-07-14
申请号：US14912984
申请日：2014-08-21
IPC分类号： C07K14/635 , B01D15/36 , C07K1/18
CPC分类号： C07K14/635 , B01D15/363 , C07K1/18
摘要： The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH1-34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) Enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.
摘要翻译： 本发明涉及用于纯化重组甲状旁腺激素（rhPTH1-34或特立帕定）的改进方法，所述方法用于纯化甲状旁腺激素，其包括以下必要步骤：（a）酶切; （b）阴离子交换层析，然后进行其他合适的纯化步骤; 其中步骤（a）和（b）可以以任何顺序进行。
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公开(公告)号：US20190071496A1
公开(公告)日：2019-03-07
申请号：US16123293
申请日：2018-09-06
IPC分类号： C07K16/24 , A61K47/26 , A61K47/18 , A61K9/19 , A61K39/395
摘要： The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are useful for stabilization of antibody preparations. Additionally, the novel formulation of the present invention prevents the formation of aggregates or fragments or modification of protein in solution.
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公开(公告)号：US20160115195A1
公开(公告)日：2016-04-28
申请号：US14895432
申请日：2014-06-25
CPC分类号： C07K1/36 , C07K16/065 , C07K16/241 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/21 , C07K2317/24
摘要： The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography. It provides more than 99% purity of the desired monoclonal antibody.
摘要翻译： 本发明提供从细胞培养物纯化单克隆抗体的改进方法。 纯化所需单克隆抗体的方法包括亲和力，疏水相互作用和任选的离子交换柱层析。 它提供超过99％纯度的所需单克隆抗体。
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公开(公告)号：US20150071936A1
公开(公告)日：2015-03-12
申请号：US14383533
申请日：2013-03-05
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , A61K9/19 , A61K39/39591 , A61K47/183 , A61K47/26 , C07K2317/21 , C07K2317/76 , C07K2317/94
摘要： The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are useful for stabilization of antibody preparations. Additionally, the novel formulations of the present invention prevents the formation of aggregates or fragments or modifications of protein in solution.
摘要翻译： 本发明提供某些改进的蛋白质制剂。 具体地，本发明提供了可用于抗体制剂稳定化的某些赋形剂的用途。 此外，本发明的新型制剂防止在溶液中形成聚集体或蛋白质的片段或修饰。
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