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公开(公告)号：US10345572B2
公开(公告)日：2019-07-09
申请号：US15422241
申请日：2017-02-01
Applicant: California Institute of Technology
Inventor： Eugene Serabyn , Christian A. Lindensmith , James K. Wallace , Kurt M. Liewer , Jay L. Nadeau
Abstract: In situ investigation of microbial life in extreme environments can be carried out with microscopes capable of imaging 3-dimensional volumes and tracking particle motion. A lensless digital holographic microscope is disclosed that provides roughly 1.5 micron resolution in a compact, robust package suitable for remote deployment. High resolution is achieved by generating high numerical-aperture input beams with radial gradient-index rod lenses. The ability to detect and track prokaryotes was explored using bacterial strains of two different sizes. In the larger strain, a variety of motions were seen, while the smaller strain was used to demonstrate a detection capability down to micron scales.
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公开(公告)号：US20160131882A1
公开(公告)日：2016-05-12
申请号：US14939389
申请日：2015-11-12
Applicant: California Institute of Technology
Inventor： James K. Wallace , Kurt M. Liewer , Christian A. Lindensmith , Eugene Serabyn , Stephanie Rider , Emilio C. Graff
CPC classification number: G02B21/0056 , G02B21/0008 , G02B21/0072 , G02B21/008 , G02B21/18 , G03H1/0443 , G03H2001/005 , G03H2001/0445 , G03H2222/12 , G03H2222/13 , G03H2227/02
Abstract: A digital holographic microscope including a single mode fiber collimated light source which provides illumination for both the ‘science’ and ‘reference’ arms, a pair of microscope objectives located side-by side, and illuminated by the common beam, a relay lens whose center is between the two objectives, and a focal plane element where the interference pattern is measured. A lens-less digital holographic microscope and a reflective digital holographic microscope are also disclosed.
Abstract translation: 一种数字全息显微镜，包括单模光纤准直光源，为“科学”和“参考”臂提供照明，一对显微镜物镜并排定位并由共用光束照射，中心透镜的中心 在两个目标之间，并且测量干涉图案的焦平面元件。 还公开了无镜头数字全息显微镜和反射数字全息显微镜。
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公开(公告)号：US10054777B2
公开(公告)日：2018-08-21
申请号：US14939389
申请日：2015-11-12
Applicant: California Institute of Technology
Inventor： James K. Wallace , Kurt M. Liewer , Christian A. Lindensmith , Eugene Serabyn , Stephanie Rider , Emilio C. Graff
CPC classification number: G02B21/0056 , G02B21/0008 , G02B21/0072 , G02B21/008 , G02B21/18 , G03H1/0443 , G03H2001/005 , G03H2001/0445 , G03H2222/12 , G03H2222/13 , G03H2227/02
Abstract: A lens-less digital holographic microscope, a reflective digital holographic microscope, and a digital holographic microscope including a plurality of lenses. In one example, the digital holographic microscope includes a single mode fiber collimated light source which provides illumination for both the ‘science’ and ‘reference’ arms, a pair of microscope objectives located side-by side, and illuminated by the common beam, a relay lens whose center is between the two objectives, and a focal plane element where the interference pattern is measured.
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公开(公告)号：US20170219999A1
公开(公告)日：2017-08-03
申请号：US15422241
申请日：2017-02-01
Applicant: California Institute of Technology
Inventor： Eugene Serabyn , Christian A. Lindensmith , James K. Wallace , Kurt M. Liewer , Jay L. Nadeau
CPC classification number: G02B23/2484 , G02B3/0087 , G02B6/0005 , G02B6/0006 , G02B6/0008 , G02B21/365 , G02B23/2469 , G02B23/26 , G03H1/0443 , G03H1/0465 , G03H2001/005 , G03H2001/0436 , G03H2001/0445 , G03H2001/0469 , G03H2001/0471 , G03H2222/52 , G03H2223/17
Abstract: In situ investigation of microbial life in extreme environments can be carried out with microscopes capable of imaging 3-dimensional volumes and tracking particle motion. A lensless digital holographic microscope is disclosed that provides roughly 1.5 micron resolution in a compact, robust package suitable for remote deployment. High resolution is achieved by generating high numerical-aperture input beams with radial gradient-index rod lenses. The ability to detect and track prokaryotes was explored using bacterial strains of two different sizes. In the larger strain, a variety of motions were seen, while the smaller strain was used to demonstrate a detection capability down to micron scales.
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