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公开(公告)号：US20180327793A1
公开(公告)日：2018-11-15
申请号：US15970674
申请日：2018-05-03
发明人： Christina E. Boville , Sabine Brinkmann-Chen , Andrew R. Buller , David K. Romney , Christopher K. Prier , Philipp Koch , Remkes Scheele
IPC分类号： C12P13/22 , C07K14/415 , C12P13/06 , C12P13/00
CPC分类号： C12P13/227 , C07K14/415 , C12N15/8254 , C12P13/005 , C12P13/06 , C12Y402/0102
摘要： The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.
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2.发明申请ENGINEERED BETA-SUBUNIT OF TRYPTOPHAN SYNTHASE FOR PRODUCTION OF NON-CANONICAL AMINO ACIDS 审中-公开用于生产非经典氨基酸的TRYPTOPHAN SYNTHASE的工程化亚甲基公开(公告)号：US20160298152A1
公开(公告)日：2016-10-13
申请号：US15094458
申请日：2016-04-08
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
CPC分类号： C12P13/227 , C12N9/88 , C12P13/04 , C12Y402/0102
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
摘要翻译： 本公开涉及修饰的色氨酸合酶，更具体地涉及色氨酸合酶的修饰的β-亚基。 本公开还涉及表达这种修饰的亚基的细胞和产生非标准氨基酸的方法。
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公开(公告)号：US12024731B2
公开(公告)日：2024-07-02
申请号：US17556555
申请日：2021-12-20
发明人： Christina E. Boville , Sabine Brinkmann-Chen , Andrew R. Buller , David K. Romney , Christopher K. Prier , Philipp Koch , Remkes A. Scheele
CPC分类号： C12P13/227 , C07K14/415 , C12N9/88 , C12P13/005 , C12P13/04 , C12P13/06 , C12N15/8254 , C12Y402/0102
摘要： The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.
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公开(公告)号：US11279959B2
公开(公告)日：2022-03-22
申请号：US16820538
申请日：2020-03-16
发明人： Christina E. Boville , Sabine Brinkmann-Chen , Andrew R. Buller , David K. Romney , Christopher K. Prier , Philipp Koch , Remkes A. Scheele
IPC分类号： C12N9/06 , C12N1/21 , C12P13/04 , C12P13/22 , C07K14/415 , C12P13/00 , C12P13/06 , C12N9/88 , C12N15/82
摘要： The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.
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5.发明授权公开(公告)号：US11879143B2
公开(公告)日：2024-01-23
申请号：US16691452
申请日：2019-11-21
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
CPC分类号： C12P13/227 , C12N9/88 , C12P13/04 , C12Y402/0102
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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公开(公告)号：US20220364130A1
公开(公告)日：2022-11-17
申请号：US17556555
申请日：2021-12-20
发明人： Christina E. Boville , Sabine Brinkmann-Chen , Andrew R. Buller , David K. Romney , Christopher K. Prier , Philipp Koch , Remkes A. Scheele
摘要： The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.
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7.发明授权公开(公告)号：US10513719B2
公开(公告)日：2019-12-24
申请号：US15094458
申请日：2016-04-08
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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8.发明公开公开(公告)号：US20240218406A1
公开(公告)日：2024-07-04
申请号：US18533016
申请日：2023-12-07
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
CPC分类号： C12P13/227 , C12N9/88 , C12P13/04 , C12Y402/0102
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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公开(公告)号：US20200340024A1
公开(公告)日：2020-10-29
申请号：US16820538
申请日：2020-03-16
发明人： Christina E. Boville , Sabine Brinkmann-Chen , Andrew R. Buller , David K. Romney , Christopher K. Prier , Philipp Koch , Remkes A. Scheele
摘要： The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.
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10.发明申请公开(公告)号：US20200149078A1
公开(公告)日：2020-05-14
申请号：US16691452
申请日：2019-11-21
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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